Find hotels in Cairo, IL from $64

Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Americas Best Value Inn Ullin Mounds and Quality Inn Charleston I-57. See all available top hotels, or vacation rentals in Cairo.

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This vacation home rental near Cairo is located in a rural location and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Cairo.

Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.

For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.

Quality Inn Cairo I-57 is a top hotel with a seasonal outdoor pool, free full breakfast, and free WiFi.

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 23 hotels and other accommodations in the surrounding area. Find out more about Cairo.

The picturesque setting of Mississippi River and Fort Defiance State Park exemplify the area's natural beauty. You'll also find Mound City National Cemetery and Columbus-Belmont State Park in the area. Check out what more to see and do in Expedia's Cairo guide.

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.