From Chillicothe, it's roughly 85 miles (137 kilometers) to the west to Cincinnati and 120 miles (193 kilometers) to the southwest to Lexington.
No two towns or cities are identical; each is endowed with its own magic. So, if you have time, discover a few of the other places surrounding Chillicothe. South Bloomingville, 20 miles (32 kilometers) to the west, and Jackson, 25 miles (40 kilometers) to the northwest of Chillicothe are worth visiting if you're keen to explore this region further.
When you are ready to head further afield beyond Chillicothe, why not visit the nearest regional center. Columbus sits 45 miles (72 kilometers) away and is home to attractions like Hollywood Casino, Ohio Stadium and Franklin Park Conservatory. Don't rush back to Chillicothe until you've checked out Columbus' Columbus Motor Speedway, Ohio Theater and Ohio State Fairgrounds.
Take a trip to Southeast's popular historic bridges, it's a great way to familiarize yourself with the region's fascinating past.
Breathe in and de-stress as you try out this region's relaxing pursuits such as bird watching and shore fishing.
The closest major airport, Port Columbus International Airport, is located in Columbus, 45 miles (72 kilometers) to the north of Chillicothe, which is handy to remember when booking your trip.