Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Save up to $603 by booking Flight + Hotel.

Search 321,000 hotels and 400 airlines worldwide.

Get the price Guarantee available for your trip.


South San Francisco Vacation Travel Guide

Vacationing is good for the soul. It lets you rest, relax, recharge, and refresh, so you’re ready to take on new endeavors when you return home. When it’s time to let loose and embark on a group adventure or unwind and rejuvenate on a solo sojourn, turn to Expedia for major discounts on South San Francisco vacation packages.

It’s easy to book the getaway of your dreams when you search through our selection of South San Francisco vacations. Our goal? To create the perfect trip for you by providing the largest selection of vacation packages. Confidently book your getaway thanks to our trustworthy recommendations and verified consumer reviews from travelers just like you. Personalize your South San Francisco package with our myriad of hotel rooms and flight tickets, which help to create a vacation specifically for you. Simply sort through our selection and pick and choose the elements that best suit your preferences and price range.

Because we offer the best rates, you can book your travel reservations knowing you won’t find lower prices elsewhere. These discounts are so great, you’ll feel like you gained the title of the ultimate bargain hunter with our South San Francisco vacation package deals. Whether you’re looking to book multiple flights, stay at the fanciest hotel, or explore the hottest local attractions, you’ll find discounted travel arrangements within your budget right here. You shouldn’t have a care in the world when you go on vacation, so our discounts allow you to rest easy without giving your bank account a second thought. Save money on your vacation today and revel in your much-deserved getaway tomorrow.


Top Hotel Deals

See all 710 Hotels in South San Francisco
$76
Travelodge San Francisco Airport-North

Travelodge San Francisco Airport-North

326 S Airport Blvd, South San Francisco
2.5
of 5, from 2,325 reviews
2.0 out of 5.0

This 200-room hotel is 2 miles north of San Francisco International Airport and 10 miles from downtown San Francisco.

$119
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
3.2
of 5, from 62 reviews
3.0 out of 5.0

Hotel Focus SFO is 3 miles (4.8 km) from San Francisco International Airport and a 15-minute walk from So. California Caltrain Station. It's a half-hour drive to the Golden Gate Bridge, and there are great retail and dining options at The Shops at Tanforan, a 10-minute drive from the hotel.

$110
Larkspur Landing South San Francisco - An All-Suite Hotel

Larkspur Landing South San Francisco - An All-Suite Hotel

690 Gateway Blvd, South San Francisco
4.2
of 5, from 809 reviews
3.0 out of 5.0

This all-suite hotel is conveniently located on a quiet street in an office park in South San Francisco, less than 4 miles from San Francisco International Airport.

$110
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

380 S Airport Boulevard, South San Francisco
3.7
of 5, from 1,528 reviews
3.0 out of 5.0

This high-rise hotel offers: complimentary shuttle service to and from the San Francisco airport, less than 2 miles away; easy access to downtown via BART connection at airport.

$139
La Quinta Inn San Francisco Airport North

La Quinta Inn San Francisco Airport North

20 Airport Blvd, South San Francisco
3.4
of 5, from 925 reviews
2.5 out of 5.0

2 blocks from the South San Francisco Conference Center and 1 mile from the airport, this hotel offers complimentary airport transportation, and downtown San Francisco is 12 miles north.

$134
Park Pointe Hotel

Park Pointe Hotel

245 S Airport Blvd, South San Francisco
2.8
of 5, from 56 reviews
2.0 out of 5.0

Ideal for a comfortable layover, Park Pointe Hotel places guests 1 mile (0.6 km) north of San Francisco International Airport. The hotel’s free shuttle gets to Terminal 1 in 7 minutes and also connects with the airport’s BART metro station, allowing easy access to San Francisco and Oakland.

$121
Holiday Inn San Francisco International Airport

Holiday Inn San Francisco International Airport

275 S Airport Blvd, South San Francisco
3.3
of 5, from 445 reviews
3.0 out of 5.0

Located less than 3 miles from San Francisco International Airport, this South San Francisco hotel is also within 17 miles of the Golden Gate Bridge.

$159
Embassy Suites San Francisco Airport - South San Francisco

Embassy Suites San Francisco Airport - South San Francisco

250 Gateway Blvd, South San Francisco
4.0
of 5, from 679 reviews
3.5 out of 5.0

SFO airport is only 3 miles away, and there's a free trolley to downtown San Francisco on Fridays and Saturdays.

Top Flight + Hotel Deals

Top Deals on Flights

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.