If you're craving some mental stimulation, make a trip to Museum of Oaxacan Culture. Whether it's history, culture or beliefs, you'll find lots of thought-provoking displays to keep your mind active here.
This collection of historical artifacts is in Ruta Independencia, a place that has so much going for it! Zocalo Square, Oaxaca Cathedral and Benito Juarez Market are other interesting sightseeing choices close by when you've finished up at Museum of Oaxacan Culture.