Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Texas Medical Center 3 Star Hotels

See all 611 Hotels in Texas Medical Center
Wyndham Houston - Medical Center Hotel and Suites

Wyndham Houston - Medical Center Hotel and Suites

6800 Main Street, Houston
    3.5 out of 5.0
     
     
    4.0 out of 5 (1,499 reviews)
    The hotel is convenient to Rice University. Our stay was good overall (except for parking problems, described below). The beds were comfortable, the A/C unit made enough noise that it blocked out sounds, and the staff were pleasant and helpful (we especially appreciated the list of neighboring restaurants). ...
    Apr 17, 2018

    Wyndham Houston - Medical Center Hotel and Suites$87

    Wyndham Houston - Medical Center Hotel and Suites$87
    Sheraton North Houston at George Bush Intercontinental

    Sheraton North Houston at George Bush Intercontinental

    15700 John F Kennedy Blvd, Houston
      3.5 out of 5.0
       
       
      4.2 out of 5 (1,665 reviews)
      Only stayed one nightEverything was good. The food was great. I would stay there again.
      Apr 21, 2018

      Sheraton North Houston at George Bush Intercontinental$79

      Sheraton North Houston at George Bush Intercontinental$79
      Holiday Inn - Houston Westchase

      Holiday Inn - Houston Westchase

      10609 Westpark Dr, Houston
        3.0 out of 5.0
         
         
        4.4 out of 5 (814 reviews)
        Hotel in HoustonI would’ve gave it a perfect score but the MAIN reason I come to hotels is to feel relaxed and the BREAKFAST it said free breakfast on the site but definitely was NOT free unless you pay extra smh staff was nice though
        Apr 22, 2018

        Holiday Inn - Houston Westchase$74

        Holiday Inn - Houston Westchase$74
        Hyatt Place Houston/Galleria

        Hyatt Place Houston/Galleria

        5252 W. Alabama, Houston
          3.0 out of 5.0
           
           
          4.3 out of 5 (799 reviews)
          Nice hotel near Galleria shopping and restaurantsEverything was great from the staff to the room. Only negative we had was our first night there they had a special meeting or dinner that they were hosting in the check-in area which was also in the area of the bar so were unable to sit at the bar and enjoy a relaxing drink. Thought they should have ...
          Apr 10, 2018

          Hyatt Place Houston/Galleria$98

          Hyatt Place Houston/Galleria$98
          SpringHill Suites by Marriott Houston Intercontinental Arprt

          SpringHill Suites by Marriott Houston Intercontinental Arprt

          15840 John F Kennedy Blvd, Houston
            3.0 out of 5.0
             
             
            4.6 out of 5 (1,256 reviews)
            Close to the airport Fantastic and very friendly front desk staff. Location and breakfast included made me choose this hotel
            Apr 22, 2018

            SpringHill Suites by Marriott Houston Intercontinental Arprt$93

            SpringHill Suites by Marriott Houston Intercontinental Arprt$93
            Aloft Houston by the Galleria

            Aloft Houston by the Galleria

            5415 Westheimer Road, Houston
              3.5 out of 5.0
               
               
              4.1 out of 5 (2,487 reviews)
              Close to the galleriaNice hotel for those not trying to spend to much money. Right by the galleria.
              Mar 26, 2018

              Aloft Houston by the Galleria$107

              Aloft Houston by the Galleria$107
              Four Points by Sheraton Houston Intercontinental Airport

              Four Points by Sheraton Houston Intercontinental Airport

              1450 N Sam Houston Pkwy E, Houston
                3.0 out of 5.0
                 
                 
                4.3 out of 5 (120 reviews)
                Very quiet environment and clean. Nice room comfy bed clean linens. Nice bathroom clean I loved the mirror.
                Mar 26, 2018

                Four Points by Sheraton Houston Intercontinental Airport$84

                Four Points by Sheraton Houston Intercontinental Airport$84
                Hyatt Place Houston/Sugar Land

                Hyatt Place Houston/Sugar Land

                16730 Creek Bend Drive, Sugar Land
                  3.0 out of 5.0
                   
                   
                  4.6 out of 5 (1,034 reviews)
                  Excellent place for vacation families. Quiet, roomy, friendly staff.
                  Apr 22, 2018
                  Four Points by Sheraton Houston Greenway Plaza

                  Four Points by Sheraton Houston Greenway Plaza

                  2828 Southwest Fwy, Houston
                    3.0 out of 5.0
                     
                     
                    3.8 out of 5 (3,902 reviews)
                    Very good. Great friendly staff. Excellent service in the dining room and bar.
                    Apr 22, 2018

                    Four Points by Sheraton Houston Greenway Plaza$71

                    Four Points by Sheraton Houston Greenway Plaza$71
                    Courtyard by Marriott Houston Intercontinental Airport

                    Courtyard by Marriott Houston Intercontinental Airport

                    15838 John F Kennedy Blvd, Houston
                      3.0 out of 5.0
                       
                       
                      4.5 out of 5 (104 reviews)
                      Close to airport and very neat and cleanLooks like a fairly new hotel very close to the airport. Great rooms and helpful staff. Shuttle runs every 30min. A bit crowded in the shuttle but otherwise good.
                      Apr 22, 2018

                      Courtyard by Marriott Houston Intercontinental Airport$79

                      Courtyard by Marriott Houston Intercontinental Airport$79
                      Map

                      3 Stars in Texas Medical Center

                      Search for hotels in Texas Medical Center on Expedia. You can easily find your hotels in Texas Medical Center using one of the methods below:

                      • View our selection of featured hotels in Texas Medical Center
                      • Use the map to find hotels in the Texas Medical Center area you prefer
                      • Use the filters to see hotels in a specific area of Texas Medical Center, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Texas Medical Center
                      • Enter your travel dates to view the best deals on hotels in Texas Medical Center - while they last

                      Recently booked 3 Star Hotels in Texas Medical Center

                      Holiday Inn Express & Suites Houston Medical Center
                      2.5 out of 5.0
                      Last booking: 13 minutes ago
                      Wyndham Houston - Medical Center Hotel and Suites
                      3.5 out of 5.0
                      Last booking: 20 minutes ago
                      Extended Stay America - Houston - Med Ctr - NRG Park - Kirby
                      2.5 out of 5.0
                      Last booking: 38 minutes ago
                      Moody Manor Houston Medical Center
                      2.5 out of 5.0
                      Last booking: 44 minutes ago
                      Hotel Ylem
                      3.0 out of 5.0
                      Last booking: 1 hour ago
                      Americas Best Value Inn-Medical Center Downtown
                      2.0 out of 5.0
                      Last booking: 1 hour ago
                      Hotel Zaza Houston Museum District
                      4.0 out of 5.0
                      Last booking: 2 hours ago
                      Quality Inn & Suites NRG Park - Medical Center
                      2.5 out of 5.0
                      Last booking: 3 hours ago
                      Crowne Plaza Hotel Houston near Reliant - Medical
                      3.5 out of 5.0
                      Last booking: 4 hours ago