Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Buffalo 4 Star Hotels

See all 129 Hotels in Buffalo
Millennium Buffalo

Millennium Buffalo

2040 Walden Ave, Cheektowaga
4.0 out of 5.0
4.1 out of 5 (647 reviews)
Nice place. Bar could have been better. Overall nice spot to stay
  Dec 10, 2017

$98

$98
The Delavan Hotel & Spa

The Delavan Hotel & Spa

6461 Transit Road, Cheektowaga
4.5 out of 5.0
4.6 out of 5 (293 reviews)
Wonderful serviceThe front desk staff and valet service was exceptional. Room was beautiful and very clean. Would recommend. Close to Buffalo airport.
  Dec 4, 2017

$119

$119
Wyndham Garden Buffalo Williamsville

Wyndham Garden Buffalo Williamsville

5195 Main Street, Williamsville
4.0 out of 5.0
4.7 out of 5 (743 reviews)
Quiet stay at nice hotelThis was my third stay at this hotel. Friendly staff, nice facilities and comfortable, quiet room. I like the fact that the blinds keep the light out in the morning, you rarely hear any noise from the other rooms and that there is a covered parking garage connected to the hotel - a bonus for Buffalo ...
  Dec 4, 2017

$112

$112
Reikart House, Buffalo, a Tribute Portfolio Hotel

Reikart House, Buffalo, a Tribute Portfolio Hotel

5000 Main Street, Amherst
4.5 out of 5.0
4.7 out of 5 (37 reviews)
Great alternative to the usual ChainsGreat alternative to the usual chains. Stay in this super comfortable, clean, quiet hotel for the same or less you’ll pay for inferior chains. The hotel is brand new condition, wonderfully located (near highways and many restaurants: Try Spot for coffee and casual food all day, Break n Eggs for quality ...
  Dec 10, 2017

$127

$127
Hotel Henry Urban Resort

Hotel Henry Urban Resort

444 Forest Avenue, Buffalo
4.0 out of 5.0
4.2 out of 5 (49 reviews)
New Property...Old Fashion FeelThe Hotel Henry is less than a year old, but nestled into a nationally recognized historic building dating back to the late 1800’s. Many of the structure’s original features have been preserved and integrated with modern amenities. The rooms are spotlessly clean and very comfortable. The 100 Acres ...
  Dec 9, 2017

$160

$160
DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst

10 Flint Rd, Amherst
4.0 out of 5.0
4.0 out of 5 (901 reviews)
Extra chargesHotel was excellent. However I booked at one rare and then received additional charges with no explanation. I expect Expedia rate to be complete & i expect Doubletree to inform me if extra charges.
  Nov 19, 2017

$83

$83
Buffalo Marriott Niagara

Buffalo Marriott Niagara

1340 Millersport Hwy, Amherst
4.0 out of 5.0
4.0 out of 5 (761 reviews)
Nice hotel! Close to Ontario, Canada. Very clean hotel. Nice staff. Easy check in. Good food and good drinks at the hotel bar. Nice bartenders. We had a great time! Close to Canada so bring your passport
  Nov 18, 2017

$107

$107
The Westin Buffalo

The Westin Buffalo

250 Delaware Ave, Buffalo
4.5 out of 5.0
4.6 out of 5 (51 reviews)
fantastic great rooms, clean hotel, fitness room was top notch, cool restaurant the only knock would be for Jake's Café to be open on the weekends- location was great!! incredibly decorated
  Nov 15, 2017

$161

$161
Roycroft Inn

Roycroft Inn

40 S Grove St., East Aurora
4.0 out of 5.0
4.5 out of 5 (159 reviews)
Enjoyable to stay after a Bills game. Close to the stadium and restaurants
  Dec 11, 2017

$145

$145
Buffalo Marriott Harborcenter

Buffalo Marriott Harborcenter

95 Main St, Buffalo
4.0 out of 5.0
4.7 out of 5 (110 reviews)
Sabres game dayVery clean, comfortable room. Close parking to the elevators. Easy to get to and from the arena without waiting for the crowds to clear out or traffic. Bed is very comfortable and we were able to watch Netflix on the tv. Modern room with a lot of space. Only issue encountered was the bathroom door ...
  Dec 2, 2017

$152

$152
Map

The get-go of any trip gets started with picking a spot. Buffalo is a popular local with travelers because of all its local amenities. However, "location, location, location" applies to more than just your destination. When you want to make your upcoming holiday unforgettable, it's all about where you wake up each morning.

Hotels as Scenic as the City

Buffalo saw its fair share of visitors last year. Our review section features tips and tricks on which accommodation will meet your desires for a wonderful holiday. The resorts found here aim to make your vacation as enjoyable as your nights spent checking out Buffalo. These hotels work hard to make the facilities and grounds hospitable during your visit. You won't have to venture far for a tasty breakfast, to keep up with your exercise schedule, or a refreshing swim. Buffalo has dozens of terrific accommodations that make for the perfect getaway.

Rooms have been fashioned to keep you as comfortable as possible, with amenities like ultra-comfortable bedding, in-room tea or coffee, and specially designed bathroom products. So, sit back and relax. Moreover, if you find yourself in need of something else, you can trust the staff will try their best to ensure you stay happy during your stay there. These properties are so nice that you'll regret the day you have to leave.

Book a 4-Star Hotel in Buffalo Today!

A trip to Buffalo should be a getaway from your daily worries. Book a 4-star hotel in The City of Good Neighbors soon, because everybody else is as well.