Beginning of main content

Best 4 stars Hotels in Florida Keys

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Florida Keys Hotels

Search Flight + Hotel

Advanced options

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 stars Hotels

See all 265 Hotels in Florida Keys
Hyatt Centric Key West Resort and Spa
Hyatt Centric Key West Resort and Spa
601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (657 reviews)
Hide review
Great place.... Great view ! The Hyatt is by far one of the best places to stay in Key West. The service was outstanding, the food was great and the view is worth every penny.
  May 4, 2017

$259

$259
The Gardens Hotel
The Gardens Hotel
526 Angela Street, Key West
4.0 out of 5.0
4.8 out of 5 (111 reviews)
Hide review
Small boutique hotel with the best beds! Elegant small boutique hotel. Close enough to Duvall but far enough to be quiet and relaxing. Absolutely the best beds ever.
  May 7, 2017

$319

$319
Southernmost Beach Resort
Southernmost Beach Resort
508 South St, Key West
4.0 out of 5.0
4.5 out of 5 (1,358 reviews)
Hide review
Absolutely Beautiful Hotel !!! Amazing experience here. The room, the grounds and the service is top notch. One of the nicest spots you can stay on Key West.
  May 20, 2017

$299

$299
Little Palm Island Resort & Spa - A Noble House Resort
Little Palm Island Resort & Spa - A Noble House Resort
28500 Overseas Hwy, Little Torch Key
4.5 out of 5.0
4.9 out of 5 (21 reviews)
Hide review
Incredible experience from start to finish; the staff was terrific and the experience was everything I thought it would be
  Mar 2, 2017

$990

$990
Pier House Resort & Spa
Pier House Resort & Spa
1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (612 reviews)
Hide review
Fantastic resort. We will for sure stay there again
  May 19, 2017

$299

$299
Ocean Key Resort - A Noble House Resort
Ocean Key Resort - A Noble House Resort
Zero Duval St., Key West
4.0 out of 5.0
4.6 out of 5 (711 reviews)
Hide review
Room booked was not what we received The first time we stayed at the Ocean Key we would have rated it 5 stars, this time, not so much. We paid a lot extra for what was described as an island view, what we got was a view of Duvall Street! When ask about it, we were told, Key West is an island so you did get an island view!!! That's pretty ...
  May 16, 2017

$289

$289
Santa Maria Suites
Santa Maria Suites
1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (355 reviews)
Hide review
Santa Maria Suites was a wonderful hotel! We enjoyed everything about this hotel, from the front desk staff of Ken and Matilda, to the pool bartender and room service people. Everyone was so friendly. The modern accommodations were clean and comfortable. The amenities (wine, Dove bars, Ghiardelli chocolates , muffins and bottled water in ...
  Apr 28, 2017

$289

$289
Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and Resort
2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (451 reviews)
Hide review
Very beautiful resort. Wonderful experience. Tranquility is the perfect word to describe this beautiful resort. The cottages have more than enough room to accommodate a family. The pool was wonderful. Our kids loved it. The beach was peaceful and relaxing. Not the kind of beach you find along the Atlantic. Loved the experience at Tranquility ...
  May 13, 2017

$179

$179
Cheeca Lodge & Spa
Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (634 reviews)
Hide review
Very elegant resort When we arrive, we were nicely greeted by the valet and then went to check in, we were greeted with glasses of champagne - NICE!
  May 19, 2017

$199

$199
Parrot Key Hotel & Resort
Parrot Key Hotel & Resort
2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,108 reviews)
Hide review
What a wonderful hotel. We arrived and were quickly checked in. The hotel is incredible. The staff were excellent. The staff who helped us get our stuff to our room were amazing. Especially wonderful were the cats that roamed the facility. They were very well taken care of. They kept the chickens away. The four swimming ...
  May 15, 2017

$199

$199
Map

Florida Keys Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Florida Keys, United States of America are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Florida Keys 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Florida Keys. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Florida Keys, United States of America, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Florida Keys hotels offer everything your heart desires.

Recently booked Florida Keys hotels

Cheeca Lodge & Spa
4.0 out of 5.0
Last booking: 47 minutes ago
Parrot Key Hotel & Resort
4.0 out of 5.0
Last booking: 5 hours ago
Casa Marina Resort - A Waldorf Astoria Resort
4.0 out of 5.0
Last booking: 6 hours ago