Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 Star Hotels

See all 1,047 Hotels in Florida Keys
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.0 out of 5.0
4.5 out of 5 (340 reviews)
Nice hotel by the marinaGreat stay. Friendly staff. Quiet and relaxing stay. Rooms were very comfortable. Great place to unwind.
  Jan 21, 2018

$179

$179
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (3,146 reviews)
Beautiful hotel and great location From the time we stepped into the lobby, we received personal attention by the most attentive staff. The resort grounds are beautiful, just like the pictures. We wouldn’t even have left the resort except we wanted to see some of the attractions. We had a very relaxing and enjoyable experience.
  Jan 21, 2018

$272

$272
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.5 out of 5.0
4.1 out of 5 (1,090 reviews)
Renovations are great. This is great value for your money. Staff is friendly and courteous. A great place from where to enjoy your stay in Key West.
  Jan 18, 2018

$143

$143
The Marker Waterfront Resort Key West

The Marker Waterfront Resort Key West

200 William Street, Key West
4.5 out of 5.0
4.5 out of 5 (879 reviews)
Key West MarathonStayed during the marathon and it was great, close to start and staff was wonderful and helpful, pool was heated and very relaxing. Perfect spot for walking around Key West.
  Jan 22, 2018

$256

$256
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.5 out of 5.0
4.2 out of 5 (193 reviews)
Wish we were still there!!!On arrival the staff was amazing especially Stacy at the front desk. It was our 30th anniversary and we were treated wonderfully. Someone on Facebook thought we were on a cruise after We posted all of the pictures from our balcony. The service was exceptional. Cant wait to return.
  Jan 20, 2018

$263

$263
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.5 out of 5.0
4.3 out of 5 (1,097 reviews)
Great Staff! Dog Friendly and Hassle FreeStaff was great. Room was great. Dog's got a gift package upon arrival that was useful. Negatives: Tub stops don't work well. Some grass blades were in my blankets upon initial inspection. Overall great place to stay in the Keys.
  Jan 21, 2018

$165

$165
Lime Tree Bay Resort

Lime Tree Bay Resort

68500 Overseas Hwy, Long Key
4.0 out of 5.0
4.1 out of 5 (552 reviews)
Need to be on siteThaere are off site apartments which are nice but quite a distance and across the highway from the resort. I would insist on a unit on site to ensure there is a view, close to the pool, beach and other amenities.
  Jan 22, 2018

$165

$165
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

3990 S Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,996 reviews)
Super comfortable with great staffEveryone was excellent. Great beds and pillows . Shuttle and free parking very convenient. Great heated pool and other facilities. Not too far away at all from downtown, and nice to get away from the bustle.
  Jan 20, 2018

$239

$239
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.5 out of 5.0
4.1 out of 5 (1,784 reviews)
Great location on DuvallStaff was friendly and accommodating. I chose to stay there, due to location and appearance of hotel, for the half marathon. Greatly enjoyed hot stone massage by an excellent masseuse after completing race. Location of hotel, made it very easy to get to popular locations throughout town without the ...
  Jan 22, 2018

$232

$232
Key Largo Bay Marriott Beach Resort

Key Largo Bay Marriott Beach Resort

103800 Overseas Hwy, Key Largo
4.0 out of 5.0
4.2 out of 5 (1,226 reviews)
Nice hotel, great beach and pool.Hotel was nice. We found the menu a little pricey and beach chairs were always saved in the morning with towels and items. Guests would usually return about 3 hours later. Bar and wait staff were incredible, maintenance and check in staff not overly friendly.
  Jan 5, 2018

$239

$239
Map

You'll see that you are in fine company with a visit to Florida Keys. Vacationers similar to you have made it one of our top most visited locals the past two years. However, "location, location, location" applies to more than just your vacation destination. When you want to make your next vacation extra special, it's all about where you start each new day.

Properties as Gorgeous as Florida Keys

Florida Keys saw thousands of tourists in 2016, and Expedia's comment section boast comments that highlight how fabulous these properties are. When you book a 4-star hotel you can breathe easy knowing that these properties aim to exceed your needs. You'll never have to search for to sustain your exercise routine, an energizing swim, or nice dinner during your stay, thanks to all that these hotels provide. They aim to make their facilities and grounds pleasing from the instant you step onto the property and with every step across their floors. Florida Keys has dozens of wonderful lodgings that make for the ideal holiday.

Rooms have been fashioned to keep you as comfortable as possible, with amenities like premium bedding, designer bathroom products, and in-room tea or coffee. So, sit back and decompress. Moreover, if you find that you're need of something else, you can trust the staff will do their best to ensure you continue to be pleased during your stay there. These accommodations are so lovely that you'll regret the day you have to return home.

Book a 4-Star Hotel in Florida Keys Today!

A trip to Florida Keys should be one that you'll recollect for years to come, and booking a 4-star hotel can help create memories that are fabulous. Book a 4-star hotel in Florida Keys soon, because several other people are too.

Recently booked 4 Star Hotels in Florida Keys

New Orleans House - Gay Men Adult Resort
3.0 out of 5.0
Last booking: 1 hour ago
Parmer's Resort
3.0 out of 5.0
Last booking: 2 hours ago
Southernmost Beach Resort
4.0 out of 5.0
Last booking: 3 hours ago
Best Western Key Ambassador Resort Inn
3.0 out of 5.0
Last booking: 4 hours ago
Paradise Inn Key West-Adults Only
4.0 out of 5.0
Last booking: 4 hours ago
Pier House Resort & Spa
4.5 out of 5.0
Last booking: 4 hours ago
Casa Marina, A Waldorf Astoria Resort
4.5 out of 5.0
Last booking: 4 hours ago
Ibis Bay Beach Resort
3.0 out of 5.0
Last booking: 5 hours ago
Silver Palms Inn
3.5 out of 5.0
Last booking: 5 hours ago