Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 Star Hotels

See all 368 Hotels in Florida Keys
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.0 out of 5.0
3.9 out of 5 (345 reviews)
nice but didnt get to staywell really didnt get to stay. had to evacuate due to the hurricane
  Sep 20, 2017

$220

$220
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (1,491 reviews)
Hurricane IrmaUnfortunatly, our 5 day stay turned into one and a half days due to hurricane Irma. However the staff remained extremely calm and professional.The rooms and property were beautiful. The food was excellent and the staff even more so. We got out two days before evacuation. Our only hope is the entire ...
  Sep 14, 2017

$239

$239
Parrot Key Hotel & Resort

Parrot Key Hotel & Resort

2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,154 reviews)
Nice hotel. Close to the water. Nice staff.Pro: Room is large and comfortable. Location is convenient. Staff are nice. It also has complementary shuttle service to downtown if you need transportation. Con: This property seems to be relatively old and is NOT sound-proof. If you're a light sleeper, or you really care about noise level - or ...
  Sep 14, 2017

$134

$134
Casa Marina, A Waldorf Astoria Resort

Casa Marina, A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.1 out of 5 (986 reviews)
Nice hotel. Nice breakfast. Poor beach. Rooms good but need bathroom remodelation. Excellent worker.
  Sep 6, 2017

$247

$247
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.0 out of 5.0
4.0 out of 5 (45 reviews)
Enjoyed it!Great place - great location. The staff was friendly and helpful. The resort fee was higher than it should be for what you get but tolerable. Would stay here again......
  Sep 2, 2017

$202

$202
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (315 reviews)
Hurricane Irmaour stay was less than 24 hours instead of 6 nights due to being evacuated because of hurricane Irma. The staff was helpful on getting us out before the hurricane hit.
  Sep 11, 2017

$183

$183
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.0 out of 5.0
4.4 out of 5 (100 reviews)
HoneymoonThe hotel and staff that we encountered were wonderful. We unfortunately arrived Monday the 4th and found out Tuesday that we needed to evacuate due to hurricane Irma. We loved everything about the hotel and will definitely be planning a return trip. The staff was very helpful when we found out that ...
  Sep 9, 2017

$140

$140
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Duck Key
4.0 out of 5.0
4.1 out of 5 (1,140 reviews)
Nice resort with its own beach and 2 pools We love staying at Hawk's Cay. I love that they have heir own little private beach/lagoon area. Main pool is beautiful, but when you want to get away from other people's kids, there is an adult pool as well. It's a little older but still really nice. My only complaint is that is that the menus have ...
  Sep 17, 2017

$255

$255
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (683 reviews)
Great location near Duval Street. The hotel has beautiful rooms with great views. The staff could not have been any nicer. The service was great. The swimming pool is nice size with comfortable chairs and umbrellas. The Shor Restaurant at the hotel has an amazing breakfast.
  Sep 7, 2017

$229

$229
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (657 reviews)
Daughter got married here on the beach at sunset. Beautiful hotel and spa facilities. Close enough to Miami in terms of travel, but you feel like you're away in the Caribbean.
  Sep 11, 2017

$149

$149
Map

You'll see that you are in fine company with a visit to Florida Keys. Vacationers similar to you have made it one of our top most visited locals the past two years. However, "location, location, location" applies to more than just your vacation destination. When you want to make your next vacation extra special, it's all about where you start each new day.

Properties as Gorgeous as Florida Keys

Florida Keys saw thousands of tourists in 2016, and Expedia's comment section boast comments that highlight how fabulous these properties are. When you book a 4-star hotel you can breathe easy knowing that these properties aim to exceed your needs. You'll never have to search for to sustain your exercise routine, an energizing swim, or nice dinner during your stay, thanks to all that these hotels provide. They aim to make their facilities and grounds pleasing from the instant you step onto the property and with every step across their floors. Florida Keys has dozens of wonderful lodgings that make for the ideal holiday.

Rooms have been fashioned to keep you as comfortable as possible, with amenities like premium bedding, designer bathroom products, and in-room tea or coffee. So, sit back and decompress. Moreover, if you find that you're need of something else, you can trust the staff will do their best to ensure you continue to be pleased during your stay there. These accommodations are so lovely that you'll regret the day you have to return home.

Book a 4-Star Hotel in Florida Keys Today!

A trip to Florida Keys should be one that you'll recollect for years to come, and booking a 4-star hotel can help create memories that are fabulous. Book a 4-star hotel in Florida Keys soon, because several other people are too.

Recently booked 4 Star Hotels in Florida Keys

Casa Marina Resort - A Waldorf Astoria Resort
4.0 out of 5.0
Last booking: 12 hours ago