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Featured Panama 4 Star Hotels

See all 522 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,848 reviews)
Nice hotelWe arrived late to the hotel but were greeted but friendly and helpful staff. The restaurant was very good. Our room was clean and the beds were very comfortable.
  Jan 17, 2018

$90

$90
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (547 reviews)
Nicer than I expected. I thought this hotel would be a typical utilitarian style place as it is near the airport. It is nicely designed and has all the amenities. Nice size pool with lots of comfy poolside seating. Lounge and restaurant was great too. Very friendly staff. Will definitely stay here again. Free airport shuttle ...
  Jan 22, 2018

$105

$105
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (730 reviews)
Great accommodations As always, a great experience. Staff are beyond helpful and professional. Room is clean and comfortable. Location is convenient with many restaurants and public transportation near. We stay here every few months and never have any complaints. Enjoyed the breakfast and Ariel and Edwin are always ...
  Jan 23, 2018

$60

$60
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,166 reviews)
Very clean, helpful staffWe were very happy to access our room 1 1/2 hours before the official check-in time, our flight having landed at 5 a.m. We highly recommend this hotel & would go back if in Panama City again.
  Jan 21, 2018

$60

$60
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.0 out of 5.0
4.4 out of 5 (1,513 reviews)
Good hotel for business tripsA good hotel but the large Lobby and bar is very noisy when there is a group or music playing ...not a good hotel for an intimate quiet drink.
  Jan 21, 2018

$86

$86
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (736 reviews)
Perfect location and more.At first I was hesitant to stay in a hotel connected to a mall. But when I looked at the location and quality of this hotel, the choice was obvious. The staff were all wonderful--very cheerful and helpful except the tours and translator lady about whom I will talk more later. The rooms were spacious, ...
  Jan 21, 2018

$97

$97
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (845 reviews)
Great location In the middle of the city and still in a quiet neighborhood downtown. Restaurants , bars and casinos walking distance or a short taxi ride away. Good full hot breakfast too. Good for business or pleasure.
  Jan 14, 2018

$79

$79
Occidental Panamá City

Occidental Panamá City

Avenida 2da Sur, Obarrio, Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (719 reviews)
Very helpful and friendly staff! Beautiful & CleanThe staff is very friendly and helpful to their guests. The staff was my favorite part of my stay at The Occidental. Every employee was very polite and helpful. I wish every establishment had a nice of a staff as this hotel. The hotel was very beautiful, clean, and lively. My only criticism is that ...
  Jan 23, 2018

$67

$67
Radisson Decapolis Panama City

Radisson Decapolis Panama City

Avenida Balboa Con Multicentro, Panama City
4.5 out of 5.0
4.4 out of 5 (606 reviews)
Great hotel in a convenient location Good location, yo can acces the hotel in an almost the straight way to the airport highway. Clean, modern and helpful staff
  Jan 14, 2018

$115

$115
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,465 reviews)
Great location, next to metro, many fast food restaurants, grocery store, casino. Nice rooftop view with pool and jacuzzi.
  Jan 22, 2018

$58

$58
Map

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Las Americas Golden Tower Panama
4.0 out of 5.0
Last booking: 1 minute ago
Plaza Paitilla Inn Hotel
3.5 out of 5.0
Last booking: 7 minutes ago
Wyndham Garden Panama City
4.0 out of 5.0
Last booking: 7 minutes ago
Principe Hotel and Suites
3.5 out of 5.0
Last booking: 17 minutes ago
TRYP by Wyndham Panamá Centro
4.0 out of 5.0
Last booking: 25 minutes ago
Continental Hotel & Casino
4.5 out of 5.0
Last booking: 36 minutes ago
Central Park Hotel & Casino
3.5 out of 5.0
Last booking: 46 minutes ago
Gamboa Rainforest Resort
4.0 out of 5.0
Last booking: 1 hour ago
Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 1 hour ago