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Featured Panama 4 Star Hotels

See all 522 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,847 reviews)
Nice hotelWe arrived late to the hotel but were greeted but friendly and helpful staff. The restaurant was very good. Our room was clean and the beds were very comfortable.
  Jan 17, 2018

$90

$90
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (542 reviews)
Close To airportExcellent choice on a quick stay in Panama huge rooms, comfortable beds and good price
  Jan 19, 2018

$105

$105
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (725 reviews)
A+ HOTEL.Can't beat the price vrs location, staff super professional, Freddy was very helpful, polite and welcoming. After a long flight all you need is a comfortable place to rest, well I had that and felt very welcomed. Novotel Panama city, you did it again, thank you.
  Dec 28, 2017

$60

$60
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,161 reviews)
Very nice stay. We arrived at 3am and the staff was waiting for us. No issues whatsoever. Best breakfast buffet we've ever had! Very cozy beds and well located.
  Jan 19, 2018

$60

$60
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.0 out of 5.0
4.4 out of 5 (1,512 reviews)
In the heart of Panama City24 hour snack store available. Easy check in. Comfortable bed and pillows.
  Jan 3, 2018

$86

$86
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (732 reviews)
Doorstep ShoppingVery convenient for shopping trip as the hotel is actually in the mall.
  Jan 19, 2018

$97

$97
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (845 reviews)
Great location In the middle of the city and still in a quiet neighborhood downtown. Restaurants , bars and casinos walking distance or a short taxi ride away. Good full hot breakfast too. Good for business or pleasure.
  Jan 14, 2018

$79

$79
Occidental Panamá City

Occidental Panamá City

Avenida 2da Sur, Obarrio, Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (717 reviews)
Good location and confortThis hotel is located very close to the main shopping mall and areas of Panama City. They have a good rooftop and also the room and hotel staff are great. Price is very affordable
  Jan 12, 2018

$67

$67
Radisson Decapolis Panama City

Radisson Decapolis Panama City

Avenida Balboa Con Multicentro, Panama City
4.5 out of 5.0
4.4 out of 5 (604 reviews)
Great hotel in a convenient location Good location, yo can acces the hotel in an almost the straight way to the airport highway. Clean, modern and helpful staff
  Jan 14, 2018

$115

$115
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,463 reviews)
Party next door Waited half and hour after informing staff about noise and smoking from next door and nothing. Had to go down in person for second request. That helped but party started again at 2 am so again security was contacted and we asked security if they could move us and waited. Nothing. Eventually went ...
  Jan 16, 2018

$58

$58
Map

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Bristol Panama
5.0 out of 5.0
Last booking: 55 minutes ago
Gamboa Rainforest Resort
4.0 out of 5.0
Last booking: 3 hours ago
The Saba Hotel
4.0 out of 5.0
Last booking: 3 hours ago
Wyndham Panama Albrook Mall
4.5 out of 5.0
Last booking: 4 hours ago
Hotel Centroamericano
3.0 out of 5.0
Last booking: 4 hours ago
Grand International Hotel
3.5 out of 5.0
Last booking: 6 hours ago
Royal Decameron Golf, Beach Resort and Villas All Inclusive
4.0 out of 5.0
Last booking: 6 hours ago
Wyndham Garden Panama City
4.0 out of 5.0
Last booking: 6 hours ago
Las Americas Golden Tower Panama
4.0 out of 5.0
Last booking: 7 hours ago