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Featured Panama 4 Star Hotels

See all 499 Hotels in Panama
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (501 reviews)
Passing By Really good hotel and shuttle service is good but can improve
  Dec 11, 2017

$101

$101
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,821 reviews)
Asked for a cot for a 3rd person in the room and some white vinegar for our unexpected sunburns and staff were extremely prompt in providing both to us!
  Dec 8, 2017

$100

$100
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (705 reviews)
Excellent hotel.Warm and fast check in. Easy check out. Magnificent breakfast. Great room. Great location. 100% recommended
  Dec 12, 2017

$60

$60
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.5 out of 5.0
4.4 out of 5 (1,495 reviews)
Great placeNice locations, great restaurant . Much Traffic to from Hotell in rush hours
  Dec 11, 2017

$89

$89
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,137 reviews)
Beautiful facilityBeautiful place! Comfortable rooms, great views of the city; Nice breakfast. Totally clean. Front desk people were pleasant, but not overly helpful. We have to probe to get complete information on events, transportation. NONE OF THE TAXI DRIVERS KNOW WHERE THE HOTEL IS! The front desk has business ...
  Dec 10, 2017

$59

$59
Occidental Panamá City

Occidental Panamá City

Avenida 2da Sur, Obarrio, Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (690 reviews)
Lots of construction going on. Found out there were hidden fees for visitors.
  Dec 11, 2017

$53

$53
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (821 reviews)
Very good hotel Very efficient check in. Staff very friendly and provided helpful information about the area and hotel.
  Dec 9, 2017

$82

$82
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,447 reviews)
Great hotel and very accommodating staff. Stayed here with my wife and two small children. The pool on the roof was great, the exercise room is quite large which was good for the children to also run around in. The staff were helpful in providing us an extra bed in our room and very helpful. It is a nice hotel and has a pretty vibrant nightlife ...
  Dec 11, 2017

$59

$59
Courtyard Panama at Multiplaza Mall

Courtyard Panama at Multiplaza Mall

Via Israel Multiplaza Pacific Mall, Panama City
4.5 out of 5.0
4.2 out of 5 (468 reviews)
Nice hotel, great locationFriendly staff, nice room, great location next to mall
  Dec 3, 2017

$79

$79
Radisson Decapolis Panama City

Radisson Decapolis Panama City

Avenida Balboa Con Multicentro, Panama City
4.5 out of 5.0
4.4 out of 5 (589 reviews)
Nice Hotel in good placeThe hotel is near a mall and comfortable. near bars and is quiet.
  Dec 4, 2017

$98

$98
Map

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Bristol Panama
5.0 out of 5.0
Last booking: 16 minutes ago
Waldorf Astoria Panama
5.0 out of 5.0
Last booking: 1 hour ago
Radisson Decapolis Panama City
4.5 out of 5.0
Last booking: 2 hours ago
Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 2 hours ago
Hotel Campestre
3.5 out of 5.0
Last booking: 3 hours ago
Avila Hotel Panama
3.5 out of 5.0
Last booking: 4 hours ago
Ramada Panama Centro Via Argentina
3.5 out of 5.0
Last booking: 5 hours ago
Eurostars Panama City
4.5 out of 5.0
Last booking: 5 hours ago
TRYP by Wyndham Panamá Centro
4.0 out of 5.0
Last booking: 6 hours ago