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Featured Panama 4 Star Hotels

See all 525 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,873 reviews)
Nice hotelEverything was great, except the airport charter was to run every 30 min, but we had to wait for 1hr.
  Feb 16, 2018

$100

$100
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (564 reviews)
Short stay near the airport. Food could improveIt was a short stay near the airport to catch another flight early the following day. All was OK., Food options and quality could be much better. Only one option for Panamanian beer? Staff was great.
  Feb 21, 2018

$105

$105
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (868 reviews)
Nice locationIt was a great experience. Hyatt is a big name. I think "management" should train staff better how to address some of customer concerns to live up to Hyatt's reputation.
  Feb 20, 2018

$85

$85
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,181 reviews)
Clean, comfortable and conveniently located. Pool with great view. Dining in hotel is okay if you’re in a pinch. Close to everything in the city.
  Feb 17, 2018

$59

$59
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (757 reviews)
Nice hotel near the metro station Nice hotel in walking distance of good restaurants and Metro station. Also near other hotels, shopping malls and Church. The staff is helpful and courteous. The only thing lacking was a pool, but there is a small Gym in the first floor with good exercise machines.
  Feb 20, 2018

$62

$62
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0
3.9 out of 5 (638 reviews)
Cute hotel near waterThe view from our room was amazing. I wanted a hotel with WiFi and a pool and the hotel was able to provide both. The location is great. We were able to walk to places to go out like Panama Brews, Inedito, Hard Rock Hotel, and the mall was across the street. Only negative experience is that we had ...
  Feb 20, 2018

$75

$75
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (754 reviews)
excellent hotel near the canal with mallexcellent hotel with mall attached to it, very close to the canal.
  Feb 20, 2018

$104

$104
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,481 reviews)
Overnight stay to fly home....Hotel is conveniently located near several good restaurants and near the Cathedral for a photo op.
  Feb 19, 2018

$66

$66
Ramada Plaza Panama Punta Pacifica

Ramada Plaza Panama Punta Pacifica

Via Israel y Calle 71, San Francisco, Panama City
4.5 out of 5.0
4.5 out of 5 (295 reviews)
Perfect location overlooking they cityGreat hotel, Staff and view. It was such a wonderful experience staying at the Ramada, Panama. Breakfast was amazing everyday, we got clean bedding and towels everyday. As for the daytime receptionist, shes very professional and accommodating. My hotel drivers Miguel and Aleandro, they are very professional ...
  Feb 13, 2018

$92

$92
Eurostars Panama City

Eurostars Panama City

Calle Ricardo Arias, Panama City
4.5 out of 5.0
4.1 out of 5 (526 reviews)
Comfortable, cheap, and central hotelThe hotel location is perfect for getting around downtown Panama City. The staff were all professional and attentive, however the hotel needs to be renovated and better maintained. The is a slight wet, moldy smell throughout the hotel and the room carpet and couch had stains.
  Feb 18, 2018

$68

$68
Map

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Hotel Casa Panamá
4.5 out of 5.0
Last booking: 1 minute ago
Panama Marriott Hotel
4.5 out of 5.0
Last booking: 1 minute ago
Hilton Garden Inn Panama
4.0 out of 5.0
Last booking: 5 minutes ago
Waldorf Astoria Panama
5.0 out of 5.0
Last booking: 6 minutes ago
Las Americas Golden Tower Panama
4.5 out of 5.0
Last booking: 11 minutes ago
TRYP by Wyndham Panamá Centro
4.0 out of 5.0
Last booking: 18 minutes ago
La Cresta Inn
3.5 out of 5.0
Last booking: 23 minutes ago
Plaza Paitilla Inn Hotel
4.0 out of 5.0
Last booking: 1 hour ago
Eurostars Panama City
4.5 out of 5.0
Last booking: 1 hour ago