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Featured Panama 4 Star Hotels

See all 525 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,875 reviews)
Nice hotelEverything was great, except the airport charter was to run every 30 min, but we had to wait for 1hr.
  Feb 16, 2018

$100

$100
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (560 reviews)
Clean, friendly, SLOW The Crowne Plaza was close to the airport and convienent for a one night stay. The stafd was very friendly but.it felt like it was everyones first day with the speed of the service. Free breakfast and coffee was a PLUS..would stay here again.
  Feb 17, 2018

$105

$105
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (866 reviews)
Hotel is in a centralized locationI believe one of my linen white shirt was removed intemtionally from my room. I had ask the maid if it was removed imadvertently, however, there were maintenance people working the floor several day so they might of taken it. I reach out to the hotel front desk and alert them and they said they would ...
  Feb 15, 2018

$78

$78
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,180 reviews)
Clean, comfortable and conveniently located. Pool with great view. Dining in hotel is okay if you’re in a pinch. Close to everything in the city.
  Feb 17, 2018

$59

$59
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (752 reviews)
Good Hotel close to Downtown PanamaNice personnel, very nice restaurant, rooms are ok and comfortable, they have security box in the room, very good idea. also a nice lounge. only bad thing is the access to the hotel but I guess there's nothing they can do about it. definitely I'll consider it in my future trips to Panama.
  Jan 30, 2018

$62

$62
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0
3.9 out of 5 (635 reviews)
Nice hotel. Close to a mall and restaurants. Very clean . Staff was helpful. A little Spanish is very helpful. Only frontline workers speak english
  Feb 13, 2018

$75

$75
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (749 reviews)
Excellent serviceThe hotel is about 30 min ride from the airport. The hotel connected us with a driver who was waiting for us at the exit of the airport. The hotel is very clean and the roof top pool and gym were very nice.
  Feb 12, 2018

$104

$104
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,477 reviews)
Everyone was very friendly and helpful. Close to lots of great restaurants and the Metro. In fact there is a great restaurant right in the Hotel as well as a small pizza place and hair salon right outside and attached to the hotel
  Feb 16, 2018

$62

$62
Ramada Plaza Panama Punta Pacifica

Ramada Plaza Panama Punta Pacifica

Via Israel y Calle 71, San Francisco, Panama City
4.5 out of 5.0
4.5 out of 5 (292 reviews)
Perfect location overlooking they cityGreat hotel, Staff and view. It was such a wonderful experience staying at the Ramada, Panama. Breakfast was amazing everyday, we got clean bedding and towels everyday. As for the daytime receptionist, shes very professional and accommodating. My hotel drivers Miguel and Aleandro, they are very professional ...
  Feb 13, 2018

$92

$92
Eurostars Panama City

Eurostars Panama City

Calle Ricardo Arias, Panama City
4.5 out of 5.0
4.1 out of 5 (524 reviews)
Nice hotel close to restaurantsVery cleann.. staff is friendly.. food need to improve.. 24 access to transportation.. nice city view..Casino .. good parkin space
  Feb 9, 2018

$68

$68
Map

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Wyndham Garden Panama City
4.0 out of 5.0
Last booking: 41 minutes ago
Hotel Gatto Blanco & Rooftop Club
4.0 out of 5.0
Last booking: 51 minutes ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 55 minutes ago
DoubleTree by Hilton Hotel Panama City
4.5 out of 5.0
Last booking: 1 hour ago
Sheraton Bijao Beach Resort - All Inclusive
4.0 out of 5.0
Last booking: 1 hour ago
Hotel Centroamericano
3.5 out of 5.0
Last booking: 1 hour ago
Hilton Panama
5.0 out of 5.0
Last booking: 1 hour ago
Trump International Hotel and Tower Panama
5.0 out of 5.0
Last booking: 2 hours ago
RIU Plaza Panama
4.5 out of 5.0
Last booking: 2 hours ago