Beginning of main content

4 Star Hotels in Panama

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Panama Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama 4 Star Hotels

See all 463 Hotels in Panama
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
4.5 out of 5.0
4.4 out of 5 (68 reviews)
Great Hotel and Casino in Panama City ObarrioThis is a great and modern hotel in a convenient location in the city. The staff are friendly and will provide any kind of assistance you may need. A casino is attached to the hotel and has a good vibe. It wasn't smoke filled and everything was clean. My only complaint would be the selection and ...
  Jul 16, 2017

$125

$125
Bocas del Mar Hotel

Bocas del Mar Hotel

Road to Boca Chica, Boca Chica
4.0 out of 5.0
4.9 out of 5 (29 reviews)
Very nice hotel with an amazing staff.We enjoyed our stay. Very relaxing place in a remote location. Certainly not touristy. Beautiful views of the ocean. The staff was extremely welcoming, friendly and accomendating. Room was clean and beds very comfortable. We'll definitely be back.
  May 1, 2017

$159

$159
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
4.5 out of 5.0
4.5 out of 5 (64 reviews)
Clean and quietView from breakfast lounge was nice. Check in lobby was so spacious.
  May 6, 2017

$149

$149
DeVille Hotel Boutique

DeVille Hotel Boutique

50 street and Beatriz M. De Cabal, Panama City
4.0 out of 5.0
4.3 out of 5 (97 reviews)
Service level not what it used to be. Night manager doesn't speak English, area becomes more prostitute-infested at night which can make it scary.
  May 20, 2017

$50

$50
Panama Marriott Hotel

Panama Marriott Hotel

52nd St. and Ricardo Arias, Panama City
4.0 out of 5.0
4.4 out of 5 (70 reviews)
Incredible Staff, Incredible Hotel I have spent much time over the past years in Panama City. From Ernestina, the lady that cleaned my room, to Carolina who cooked my breakfast, to Maria who served my meals, to Demetrio, the General Manager, I will never consider staying in a Hotel other than The Panama Marriott Hotel, in Panama City. ...
  May 28, 2017

$105

$105
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.0 out of 5.0
4.3 out of 5 (483 reviews)
Nice hotelVery nice staff how seemed to be avaiable wherever we walked
  Jul 17, 2017

$88

$88
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
4.5 out of 5.0
4.9 out of 5 (41 reviews)
Must stay when in Panama City Beautifully restored building to its former glory in the old town. Request plaza Herrera side away from clock tower which starts at 630am
  Jul 14, 2017

$178

$178
Radisson Decapolis Panama City

Radisson Decapolis Panama City

Avenida Balboa Con Multicentro, Panama City
4.0 out of 5.0
4.4 out of 5 (251 reviews)
4 Day trip to Panama cityHotel is well located within a short taxi ride to casco Antigua and the canal. Right next door to shopping. Complimentary breakfast is the best my wife and I have had and over the last 30 years we have travelled extensively. Never ate in hotel other than breakfast as there are numerous restaurants ...
  Jul 18, 2017

$98

$98
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
4.5 out of 5.0
4.1 out of 5 (727 reviews)
Very active hotelThere is s lot to do at this hotel. The nightlife is full of energy. The view from the 62 floor at night was incredible.
  Jul 6, 2017

$138

$138
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
4.0 out of 5.0
4.1 out of 5 (71 reviews)
Nice and QuiteGood stay. Bathroom a little small. Great for rest and enjoy the amennities near by.
  Jul 18, 2017

$99

$99
Map

Panama Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Panama, Panama are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Panama 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Panama. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Panama, Panama, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Panama hotels offer everything your heart desires.

Recently booked Panama hotels

Continental Hotel & Casino
4.0 out of 5.0
Last booking: 1 hour ago
Ramada Plaza Panama Punta Pacifica
4.0 out of 5.0
Last booking: 2 hours ago
Novotel Panama City
4.0 out of 5.0
Last booking: 3 hours ago