Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama 4 Star Hotels

See all 528 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,878 reviews)
close to airport, shuttle service every half hour everthing nice and clean. higly recomend..if i had to make a change to this hotel i would put a elevator in the building.
  Feb 24, 2018
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (568 reviews)
Nice hotel with good ammenities.It was really nice. Pool hours could be extended past 9. Food at the bar is good.
  Feb 24, 2018
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (873 reviews)
Will stay here again! Great location. Love the breakfast
  Feb 24, 2018
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
4.5 out of 5.0
4.3 out of 5 (2,254 reviews)
shower water pressure is like Manhattan Caio restaurant was a real treat
  Feb 18, 2018
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,182 reviews)
Clean, comfortable and conveniently located. Pool with great view. Dining in hotel is okay if you’re in a pinch. Close to everything in the city.
  Feb 17, 2018
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (758 reviews)
Nice hotel near the metro station Nice hotel in walking distance of good restaurants and Metro station. Also near other hotels, shopping malls and Church. The staff is helpful and courteous. The only thing lacking was a pool, but there is a small Gym in the first floor with good exercise machines.
  Feb 20, 2018
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0
3.9 out of 5 (641 reviews)
No hot water. Took warm showersBusiness trip. Hotel was adequate. Hotel is close to all downtown. Traffic is chaos. Like a carousel you can't get off on.
  Feb 24, 2018
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (755 reviews)
Nice for 2 nights. Glad we had not plan to spend the entire trip there. Don't like location of hotel.
  Feb 24, 2018

$104

$104
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,481 reviews)
Overnight stay to fly home....Hotel is conveniently located near several good restaurants and near the Cathedral for a photo op.
  Feb 19, 2018
Ramada Plaza Panama Punta Pacifica

Ramada Plaza Panama Punta Pacifica

Via Israel y Calle 71, San Francisco, Panama City
4.5 out of 5.0
4.5 out of 5 (296 reviews)
Perfect location overlooking they cityGreat hotel, Staff and view. It was such a wonderful experience staying at the Ramada, Panama. Breakfast was amazing everyday, we got clean bedding and towels everyday. As for the daytime receptionist, shes very professional and accommodating. My hotel drivers Miguel and Aleandro, they are very professional ...
  Feb 13, 2018

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Sortis Hotel, Spa & Casino, Autograph Collection
5.0 out of 5.0
Last booking: 1 minute ago
Azul Paradise
3.5 out of 5.0
Last booking: 5 minutes ago
Waldorf Astoria Panama
5.0 out of 5.0
Last booking: 22 minutes ago
Metro Hotel Panama
4.0 out of 5.0
Last booking: 28 minutes ago
Trump International Hotel and Tower Panama
5.0 out of 5.0
Last booking: 37 minutes ago
Swan's Cay
3.0 out of 5.0
Last booking: 58 minutes ago
Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 1 hour ago
Riu Playa Blanca - All Inclusive
4.0 out of 5.0
Last booking: 1 hour ago
Hilton Garden Inn Panama
3.5 out of 5.0
Last booking: 1 hour ago