Beginning of main content

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama 4 Star Hotels

See all 499 Hotels in Panama
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (504 reviews)
Confortable close to airport We booked here to be close to the airport but if you wanted to see the sights it is a little far out. There was nothing close so we ate at the hotel.
  Dec 12, 2017

$101

$101
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,825 reviews)
Very clean and ver close and easy to get to from the airport. I also had a very good burger at the outside pool bar. Free shuttle to the airport next morning after a complimentary breakfast. Very nice
  Dec 15, 2017

$86

$86
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (707 reviews)
Nice hotel. Nice staff. Nice room. Had a great stay.
  Dec 13, 2017

$60

$60
RIU Plaza Panama

RIU Plaza Panama

Calle 50, Urb. Marbella, Panama City
4.5 out of 5.0
4.4 out of 5 (1,497 reviews)
Great placeNice locations, great restaurant . Much Traffic to from Hotell in rush hours
  Dec 11, 2017

$89

$89
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,141 reviews)
Panama bdayBlock up from veneto and way nicer but the sidewalks and area immediately out from the hotel are not good! The area needs attention!
  Dec 15, 2017

$53

$53
Occidental Panamá City

Occidental Panamá City

Avenida 2da Sur, Obarrio, Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (694 reviews)
Great locationGood hotel, friendly staff. I would definitely recommend.
  Dec 12, 2017

$53

$53
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (824 reviews)
Efficent centraly locatedIt was a very short stay and the hotel was adequate
  Dec 14, 2017

$82

$82
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,448 reviews)
Good hotelGood, clean property. Good location. Nice local breakfast included with our rate.
  Dec 15, 2017

$59

$59
Courtyard Panama at Multiplaza Mall

Courtyard Panama at Multiplaza Mall

Via Israel Multiplaza Pacific Mall, Panama City
4.5 out of 5.0
4.2 out of 5 (468 reviews)
Nice hotel, great locationFriendly staff, nice room, great location next to mall
  Dec 3, 2017

$79

$79
Radisson Decapolis Panama City

Radisson Decapolis Panama City

Avenida Balboa Con Multicentro, Panama City
4.5 out of 5.0
4.4 out of 5 (590 reviews)
Nice Hotel in good placeThe hotel is near a mall and comfortable. near bars and is quiet.
  Dec 4, 2017

$104

$104
Map

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Central Hotel Panama
4.5 out of 5.0
Last booking: 7 minutes ago
Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 14 minutes ago
Global Hotel Panama
4.5 out of 5.0
Last booking: 18 minutes ago
Beach Break Surf Camp
2.5 out of 5.0
Last booking: 24 minutes ago
Hard Rock Hotel Panama Megapolis
5.0 out of 5.0
Last booking: 44 minutes ago
Trump International Hotel and Tower Panama
5.0 out of 5.0
Last booking: 54 minutes ago
Wyndham Garden Panama City
4.0 out of 5.0
Last booking: 1 hour ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 1 hour ago
Country Inn & Suites By Carlson Panama Canal
4.0 out of 5.0
Last booking: 1 hour ago