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Featured Panama 4 Star Hotels

See all 525 Hotels in Panama
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Vía Tocumen, Tocumen
4.5 out of 5.0
4.0 out of 5 (1,872 reviews)
Nice hotelEverything was great, except the airport charter was to run every 30 min, but we had to wait for 1hr.
  Feb 16, 2018

$100

$100
Crowne Plaza Panama Airport

Crowne Plaza Panama Airport

Ave. Domingo Diaz, Tocumen
4.5 out of 5.0
4.2 out of 5 (562 reviews)
Clean, friendly, SLOW The Crowne Plaza was close to the airport and convienent for a one night stay. The stafd was very friendly but.it felt like it was everyones first day with the speed of the service. Free breakfast and coffee was a PLUS..would stay here again.
  Feb 17, 2018

$105

$105
Hyatt Place Panama City/Downtown

Hyatt Place Panama City/Downtown

Avenida Aquilino de la Guardia, between, Panama City
4.0 out of 5.0
4.5 out of 5 (867 reviews)
Hotel is in a centralized locationI believe one of my linen white shirt was removed intemtionally from my room. I had ask the maid if it was removed imadvertently, however, there were maintenance people working the floor several day so they might of taken it. I reach out to the hotel front desk and alert them and they said they would ...
  Feb 15, 2018

$85

$85
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

Via Veneto, El Cangrejo Bellavista, Panama City
4.0 out of 5.0
4.4 out of 5 (1,180 reviews)
Clean, comfortable and conveniently located. Pool with great view. Dining in hotel is okay if you’re in a pinch. Close to everything in the city.
  Feb 17, 2018

$59

$59
Novotel Panama City

Novotel Panama City

Calle Jose I. Fabrega y Thais de Pons, Panama City
4.5 out of 5.0
4.3 out of 5 (754 reviews)
Good breakfast, clean rooms, friendly staff, fair price
  Feb 18, 2018

$62

$62
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla, Panama City
4.0 out of 5.0
3.9 out of 5 (637 reviews)
Nice hotel. Close to a mall and restaurants. Very clean . Staff was helpful. A little Spanish is very helpful. Only frontline workers speak english
  Feb 13, 2018

$75

$75
Wyndham Panama Albrook Mall

Wyndham Panama Albrook Mall

Ave. Marginal, Corregimiento de Ancon, Panama City
4.5 out of 5.0
4.5 out of 5 (753 reviews)
Great location and good value for moneyVery efficient check in. We got our room at 12:30 pm notwithstanding that the official check in time is 3:00 pm. The lobby and room are clean and nicely decorated. Restaurants in the hotel are all good and reasonably priced. Very convenient location as it is right inside the Albrook Mall.
  Feb 18, 2018

$104

$104
DoubleTree by Hilton Hotel Panama City

DoubleTree by Hilton Hotel Panama City

Via Espana, Federico Boyd & Bella Vista, Panama City
4.5 out of 5.0
4.1 out of 5 (1,480 reviews)
Overnight stay to fly home....Hotel is conveniently located near several good restaurants and near the Cathedral for a photo op.
  Feb 19, 2018

$62

$62
Ramada Plaza Panama Punta Pacifica

Ramada Plaza Panama Punta Pacifica

Via Israel y Calle 71, San Francisco, Panama City
4.5 out of 5.0
4.5 out of 5 (294 reviews)
Perfect location overlooking they cityGreat hotel, Staff and view. It was such a wonderful experience staying at the Ramada, Panama. Breakfast was amazing everyday, we got clean bedding and towels everyday. As for the daytime receptionist, shes very professional and accommodating. My hotel drivers Miguel and Aleandro, they are very professional ...
  Feb 13, 2018

$92

$92
Eurostars Panama City

Eurostars Panama City

Calle Ricardo Arias, Panama City
4.5 out of 5.0
4.1 out of 5 (526 reviews)
Comfortable, cheap, and central hotelThe hotel location is perfect for getting around downtown Panama City. The staff were all professional and attentive, however the hotel needs to be renovated and better maintained. The is a slight wet, moldy smell throughout the hotel and the room carpet and couch had stains.
  Feb 18, 2018

$68

$68

The preparation of any much-needed holiday starts with picking a location. Panama has become a popular option with tourists because it offers so much to do. But, "location, location, location" applies to more than just your destination. When you want a trip that is great from beginning to end, you need the ideal hotel.

Accommodations as Scenic as Panama

Panama saw its fair share of visitors in the last year. Expedia's review section boast tips and tricks which may help you decide which lodge is optimal for your vacation. When you book a 4-star suite you can breathe easy knowing that these properties are designed to meet your needs. These hotels aim to make the facilities and grounds welcoming during your vacation. You won't have to search for to keep up with your exercise routine, an invigorating dip, or nice meal. Panama has dozens of fantastic lodgings that provide the perfect escape.

Rooms have been furnished to keep you as cozy as possible, with amenities like ultra-comfortable bedding, specially designed bathroom products, and in-room coffee or tea. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will work their hardest to ensure you stay pleased during your stay. These accommodations are so nice that you'll regret the day you have to check-out.

Book a 4-Star Hotel in Panama Today!

A getaway to Panama should be one where you don't have to be concerned about the little things. With Expedia, you will get great deals on the best accommodations to take your getaway to greater heights.

Recently booked 4 Star Hotels in Panama

Cubitá Boutique Resort & Spa
4.0 out of 5.0
Last booking: 11 minutes ago
Holiday Inn Express Panama Distrito Financiero
3.5 out of 5.0
Last booking: 12 minutes ago
Riande Aeropuerto Hotel & Casino
4.5 out of 5.0
Last booking: 17 minutes ago
Plaza Paitilla Inn Hotel
4.0 out of 5.0
Last booking: 28 minutes ago
RIU Plaza Panama
4.5 out of 5.0
Last booking: 41 minutes ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 58 minutes ago
Hard Rock Hotel Panama Megapolis
5.0 out of 5.0
Last booking: 1 hour ago
Occidental Panamá City
4.5 out of 5.0
Last booking: 2 hours ago
Le Meridien Panama
4.5 out of 5.0
Last booking: 2 hours ago