Title: The Best 4 Star Hotels in Río Sereno  | Expedia.com

[Río Sereno Travel Guide](https://expedia.com/Rio-Sereno.dx829296881617084416)[Hotels in Río Sereno](https://expedia.com/Rio-Sereno-Hotels.d829296881617084416.Travel-Guide-Hotels)[Vacation Rentals in Río Sereno](https://expedia.com/Rio-Sereno-Vacation-Rentals.d829296881617084416.Travel-Guide-VacationRentals)[Flights to Río Sereno](https://expedia.com/Cheap-Flights-To-Rio-Sereno.d829296881617084416.Travel-Guide-Flights)[Car Rentals in Río Sereno](https://expedia.com/Car-Rentals-In-Rio-Sereno.d829296881617084416.Car-Rental-Guide)[Río Sereno Vacation Packages](https://expedia.com/Rio-Sereno.d829296881617084416.Destination-Travel-Guides)

![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg)  
###  
Upfront pricing  
Our total price for your stay includes taxes and fees
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Save 10% or more on over 100,000 hotels worldwide with Member Prices  
[Learn about One Key](https://www.expedia.com/welcome-one-key)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Check availability on Río Sereno 4 Star Hotels

Tonight

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=829296881617084416&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 7 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=829296881617084416&startDate=2026-02-07&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=829296881617084416&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=829296881617084416&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Río Sereno 4-star hotels

![Front of property](https://images.trvl-media.com/lodging/3000000/2340000/2333500/2333478/693e16e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/3000000/2340000/2333500/2333478/f7dbaa41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor banquet area](https://images.trvl-media.com/lodging/3000000/2340000/2333500/2333478/2a373c9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/3000000/2340000/2333500/2333478/e06e46ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Grande Bambito Resort

[](https://www.expedia.com/Paso-Ancho-Hotels-Casa-Grande-Bambito-Resort.h2333478.Hotel-Information)

Paso Ancho

8.4/10

Very Good

(99 reviews)

"Amazing location and beautiful hotel, will definitely come back"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lorena

[](https://www.expedia.com/Paso-Ancho-Hotels-Casa-Grande-Bambito-Resort.h2333478.Hotel-Information)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Rio-Sereno-Hotels.s40-0-d829296881617084416.Travel-Guide-Filter-Hotels)[

Sign up, it's free

](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Rio-Sereno-Hotels.s40-0-d829296881617084416.Travel-Guide-Filter-Hotels)

## Top Río Sereno Hotel Reviews

## Find out more about Río Sereno

## Río Sereno Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Río Sereno, Chiriquí Province are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Río Sereno 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Río Sereno. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Río Sereno, Chiriquí Province, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Río Sereno hotels offer everything your heart desires.