Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Francisco 4 Star Hotels

See all 522 Hotels in San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
4.0 out of 5.0
3.3 out of 5 (8,245 reviews)
The staff was nice and helpful and answered any questions we had.
  Dec 14, 2017

$105

$105
Pullman San Francisco Bay

Pullman San Francisco Bay

223 Twin Dolphin Dr, Redwood City
4.5 out of 5.0
4.3 out of 5 (2,839 reviews)
Perfect retreat!Found this hotel by accident but it turned out to be the most pleasant surprise. A beautiful hotel, tucked away from the monotony but not too far that you couldn't get to whatever attraction you wanted to see.
  Dec 8, 2017

$88

$88
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.5 out of 5.0
4.2 out of 5 (5,638 reviews)
Great STAFF - competitive rates - LOVE LOVE LOVE the location
  Dec 12, 2017

$149

$149
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.5 out of 5.0
3.8 out of 5 (3,921 reviews)
Nice hotelIt was confortable and very clean! Close to the beach and many attractions
  Dec 4, 2017

$149

$149
Clift

Clift

495 Geary St, San Francisco
4.5 out of 5.0
4.1 out of 5 (3,441 reviews)
Clean but needs to join the digital age. No charging ports, broken floor lamp switch, extra “facility charge” that reeks of extra add-on airline fees procedure. Just state pricing in one price! No amount of staff smiling will cover up this behavior.
  Dec 10, 2017

$159

$159
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.5 out of 5.0
4.3 out of 5 (6,522 reviews)
Great central location Exceptionally friendly and competent staff from doorman to person delivering bottle opener promptly to our room; impressive especially at busy Holiday time of year. Appreciate spotless grounds and room. Great walking access to Union Square and China Town. Even able to walk to Roy’s for dinner. Didn’t ...
  Dec 12, 2017

$157

$157
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.5 out of 5.0
4.3 out of 5 (3,170 reviews)
Nice hotel at Embarcadero The hotel is in a great location, where you go in a walking distance to the City sites. Cable car is a few steps away from the entrance. A lots a good restaurant in the area. The top floor had a great view where you can have a drink or snack and enjoy the beautiful view. We like this hotel for special ...
  Dec 14, 2017

$159

$159
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,376 reviews)
Good. We stayed in the older side of the building but had a nice view if union square. It was clean but of course old. It was also right next to the elevator but that did not bother us. AC did not seem to work but since it was cold it did not matter.
  Dec 14, 2017

$158

$158
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

600 Airport Blvd, Burlingame
4.5 out of 5.0
4.2 out of 5 (3,506 reviews)
Nice hotel for a short stayComfy room and friendly staff. Nice hotel for a short stay near the airport.
  Dec 9, 2017

$87

$87
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.5 out of 5.0
4.4 out of 5 (3,345 reviews)
Very friendly hotel staff. Helped my husband find our room .... Let us have a late checkout.
  Dec 14, 2017

$169

$169
Map

The get-go of any much-needed vacation starts with picking a fantastic location. San Francisco is a popular local with tourists because of all its local amenities. Location is everything, but that doesn't mean just the area you are flying into. When you want to make your next holiday extra special, it's all about where you lay your head at night.

Hotels as Beautiful as the City

San Francisco saw hundreds of guests this past year, and Expedia's review section contains tips on which property will exceed your requirements for an outstanding vacation. The hotels found here strive to make your visit as gratifying as your evenings spent checking out San Francisco. These hotels strive to make the facilities and grounds pleasing during your vacation. You will never need to go far for a tasty breakfast, to sustain your exercise routine, or a refreshing plunge. San Francisco has hundreds of wonderful lodgings that offer the ideal holiday.

Rooms have been furnished to keep your utmost comfort in mind, with amenities like ultra-comfortable bedding, and in-room coffee or tea, and designer bathroom products. So, sit back and decompress. Moreover, if you find that you are need of something else, you can rest easy the staff will work their hardest to ensure you continue to be pleased during your time there. These properties are so lovely that you'll regret the day you have to check-out.

Reserve a 4-Star Hotel in San Francisco Today!

A vacation to San Francisco should be one where you won't have to be concerned about the little things. Thanks to Expedia's comment section and info on each lodging, you will have no problem finding the perfect hotel for your next vacation to The Golden Gate City.

Recently booked 4 Star Hotels in San Francisco

Grant Hotel
2.5 out of 5.0
Last booking: 3 minutes ago
Hotel Rex San Francisco
4.0 out of 5.0
Last booking: 4 minutes ago
Le Meridien San Francisco
4.0 out of 5.0
Last booking: 6 minutes ago
Kimpton Sir Francis Drake Hotel
4.5 out of 5.0
Last booking: 7 minutes ago
Grand Hyatt San Francisco Union Square
4.5 out of 5.0
Last booking: 12 minutes ago
Courtyard by Marriott San Francisco Union Square
3.0 out of 5.0
Last booking: 15 minutes ago
Sheraton Fisherman's Wharf Hotel
4.5 out of 5.0
Last booking: 15 minutes ago
Buena Vista Motor Inn
3.0 out of 5.0
Last booking: 18 minutes ago
The Park Central San Francisco
4.5 out of 5.0
Last booking: 18 minutes ago