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Featured San Francisco 4 Star Hotels

See all 521 Hotels in San Francisco
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.0 out of 5.0
4.2 out of 5 (2,378 reviews)
Hotel Zoe was very conveniently located in the Wharf area and the staff was awesome and accommodating. Room was clean and updated. Would definitely stay there again!
  Oct 17, 2017

$209

$209
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,635 reviews)
valueWell the hotel is in the Tenderloin so ya it's a little rough, but be smart about it. It is just at the edge of the Tenderloin. Make sure to turn left when you leave the hotel or left onto O'farell and it's fine Great places nearby like Liho Liho Yacht Club! Waited at the bar for a spot was insanely ...
  Oct 16, 2017

$178

$178
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,837 reviews)
Beautiful historic hotel in the heart of San FrancIt was a wonderful experience staying at the St. Francis. WE really loved learning about all the history that occurred there, and being in an area that was so convenient to restaurants and shopping. We especially enjoyed the wine tasting with Chateau Montelena since that is one of our favorite wineries. ...
  Oct 18, 2017

$249

$249
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (2,776 reviews)
Nice hotel but over ratedMy stay at this hotel was generally OK but it was very expensive. The service was not good at all. The internet was horrible and extremely slow
  Oct 17, 2017

$232

$232
Hilton San Francisco Downtown/Financial District

Hilton San Francisco Downtown/Financial District

750 Kearny St, San Francisco
4.0 out of 5.0
4.0 out of 5 (1,195 reviews)
Last minute gatewaylast minute change of plans, hotel was convenient in the area we wanted to be. Great front desk people, room service fast, and outstanding. Extremely friendly..........would stay there again...
  Oct 17, 2017

$188

$188
Pullman San Francisco Bay

Pullman San Francisco Bay

223 Twin Dolphin Dr, Redwood City
4.0 out of 5.0
4.2 out of 5 (1,269 reviews)
great place and location very clean loved itgreat place and location very clean loved it. close to everything easy access to freeway.
  Oct 17, 2017

$143

$143
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,659 reviews)
First visit to San FranciscoGreat place. Close to everything. Arrived on Saturday morning and but room wasn't going to be ready till 4pm. They did check our luggage and when we got back took it to our room. Our room was next to the elevators which made it a bit noisy at times and we could hear the elevators all night going ...
  Oct 18, 2017

$208

$208
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.0 out of 5.0
4.3 out of 5 (1,387 reviews)
Very nice hotel. Great location too. Check-in was very quick. Front desk person was able to find a nice room facing Union Square for us even though we arrived in the morning. Staff was helpful and friendly at all times. Room service was excellent too.
  Oct 13, 2017

$209

$209
Hilton San Francisco Union Square

Hilton San Francisco Union Square

333 O'Farrell St., San Francisco
4.0 out of 5.0
3.9 out of 5 (2,991 reviews)
Very convenient location!!We stayed in tower 3 so old,and smells like the room is wet !
  Oct 18, 2017

$211

$211
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.0 out of 5.0
4.0 out of 5 (1,278 reviews)
Close to airportSpent one night, layover before Hawaii went into San Francisco use Uber will save $$. Hotel staff very friendly and helpful, clean and Air port shuttle 24 hours
  Oct 18, 2017

$149

$149
Map

The get-go of any much-needed vacation starts with picking a fantastic location. San Francisco is a popular local with tourists because of all its local amenities. Location is everything, but that doesn't mean just the area you are flying into. When you want to make your next holiday extra special, it's all about where you lay your head at night.

Hotels as Beautiful as the City

San Francisco saw hundreds of guests this past year, and Expedia's review section contains tips on which property will exceed your requirements for an outstanding vacation. The hotels found here strive to make your visit as gratifying as your evenings spent checking out San Francisco. These hotels strive to make the facilities and grounds pleasing during your vacation. You will never need to go far for a tasty breakfast, to sustain your exercise routine, or a refreshing plunge. San Francisco has hundreds of wonderful lodgings that offer the ideal holiday.

Rooms have been furnished to keep your utmost comfort in mind, with amenities like ultra-comfortable bedding, and in-room coffee or tea, and designer bathroom products. So, sit back and decompress. Moreover, if you find that you are need of something else, you can rest easy the staff will work their hardest to ensure you continue to be pleased during your time there. These properties are so lovely that you'll regret the day you have to check-out.

Reserve a 4-Star Hotel in San Francisco Today!

A vacation to San Francisco should be one where you won't have to be concerned about the little things. Thanks to Expedia's comment section and info on each lodging, you will have no problem finding the perfect hotel for your next vacation to The Golden Gate City.

Recently booked 4 Star Hotels in San Francisco

Grand Hyatt San Francisco Union Square
4.0 out of 5.0
Last booking: 2 minutes ago
San Francisco Marriott Marquis
4.0 out of 5.0
Last booking: 1 hour ago
Stanford Court San Francisco
4.0 out of 5.0
Last booking: 2 hours ago