--- title: "The Best 4 Star Hotels in Santa Maria del Rio from $67 | Expedia" description: "Find the best 4 Star Hotels in Santa Maria del Rio in 2026. Compare room rates, hotel reviews and availability. Most hotels are fully refundable." canonical: "https://www.expedia.com/4Star-Santa-Maria-Del-Rio-Hotels.s40-0-d6319948.Travel-Guide-Filter-Hotels" language: en-US market: US currency: USD prices_as_of: 2026-11-13T03:13:46Z --- Plan your trip - [Santa Maria del Rio Travel Guide](https://www.expedia.com/Santa-Maria-Del-Rio.dx6319948) - [Hotels in Santa Maria del Rio](https://www.expedia.com/Santa-Maria-Del-Rio-Hotels.d6319948.Travel-Guide-Hotels) - [Flights to Santa Maria del Rio](https://www.expedia.com/Cheap-Flights-To-Santa-Maria-Del-Rio.d6319948.Travel-Guide-Flights) - [Car Rentals in Santa Maria del Rio](https://www.expedia.com/Car-Rentals-In-Santa-Maria-Del-Rio.d6319948.Car-Rental-Guide) - [Santa Maria del Rio Vacation Packages](https://www.expedia.com/Santa-Maria-Del-Rio.d6319948.Destination-Travel-Guides) - [Vacation Rentals in Santa Maria del Rio](https://www.expedia.com/Santa-Maria-Del-Rio-Vacation-Rentals.d6319948.Travel-Guide-VacationRentals) # Find 4 Star Hotels in Santa Maria del Rio from $67 ![A valley with a river, green fields, and forested hills.](https://images.trvl-media.com/place/6319948/3843856b-8bcd-479d-bace-390df406810a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ### Upfront pricing Our total price for your stay includes taxes and fees ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) ### Be picky Search almost a million properties worldwide ## Check prices for these dates [Check prices for these dates, December 13 – 14, 2026](https://www.expedia.com/Hotel-Search?regionId=6319948&startDate=2026-12-13&endDate=2026-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&star=40) [View in a map](https://www.expedia.com/Hotel-Search?regionId=6319948&stayLength=1&daysInFuture=30&pwaOverlay=map) ## Our top choices for Santa Maria del Rio 4-star hotels ### [1\. Ramada Encore by Wyndham San Luis Potosi](https://www.expedia.com/San-Luis-Potosi-Hotels-Ramada-Encore-San-Luis-Potosi.h11491745.Hotel-Information) ![An outdoor seating area with tables and chairs, a glass enclosure, and a view of the surrounding area.](https://images.trvl-media.com/lodging/12000000/11500000/11491800/11491745/be1d8114.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: San Luis Potosi - Guest rating: 9.2/10 (Wonderful, 818 reviews) - Price: $75 nightly, $90 total, Dec 4 - Dec 5, Total with taxes and fees, for Our top choices for Santa Maria del Rio 4-star hotels - Review: Good place to stay at., by diana ### [2\. Microtel Inn & Suites by Wyndham San Luis Potosi](https://www.expedia.com/San-Luis-Potosi-Hotels-Microtel-Inn-Suites-By-Wyndham.h23510016.Hotel-Information) ![A modern hotel lobby with a reception desk, seating area, and a bar.](https://images.trvl-media.com/lodging/24000000/23520000/23510100/23510016/6296d206.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) - Location: San Luis Potosi - Guest rating: 9.4/10 (Exceptional, 1000 reviews) - Price: $56 nightly, $67 total, Dec 11 - Dec 12, Total with taxes and fees, for Our top choices for Santa Maria del Rio 4-star hotels - Review: Nice place to stay, by Antonio ## Find out more about Santa Maria del Rio ### Santa Maria del Rio Four Star Hotel Information When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Santa Maria del Rio, San Luis Potosi are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Santa Maria del Rio 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service. Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Santa Maria del Rio. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Santa Maria del Rio, San Luis Potosi, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop. Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Santa Maria del Rio hotels offer everything your heart desires. ## Frequently Asked Questions ### How much does it cost to stay in a 4-star hotel in Santa Maria del Rio? To find a 4-star hotel in Santa Maria del Rio that's within your budget, use Expedia's filter tool. Take a look at the available options during your preferred dates and use our pricing filter to set your maximum rate. You can also list your results by the most wallet-friendly property first. - Search for the lowest price from $67 ### What's the difference between 5-star and 4-star hotels in Santa Maria del Rio? Treat yourself to refined living during your Santa Maria del Rio getaway by choosing a 4-star hotel. As well as featuring upscale accommodations, these properties are typically filled with amenities, including large beds, bathrobes and more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour front desk, luxurious spas and world-class dining are only the start of the first-rate services and conveniences you'll likely have access to. ### Does Santa Maria del Rio have any 4-star all-inclusive resorts? Enjoy a stress-free vacation experience where everything is included in the upfront price by using our "All inclusive" filter. Keeping to your budget is a breeze when your accommodations, meals and many activities are already taken care of. After something different? Browse the terrific offers on Expedia's standard 4-star resorts in and around Santa Maria del Rio too. ### Are there any 4-star casino hotels in Santa Maria del Rio? To find your perfect getaway in Santa Maria del Rio, simply use our convenient filters to refine your search. With resort-style amenities and an upmarket level of service, our 4-star casino hotels are a safe bet for a good time. ## Explore a world of travel with Expedia - [Lodging](?equalTargetTab=tab-0) - [Flights](?equalTargetTab=tab-1) - [Packages](?equalTargetTab=tab-2) - [Cars](?equalTargetTab=tab-3) - [Vacation Rentals](?equalTargetTab=tab-4) - [Zaragoza Hotels](https://www.expedia.com/Zaragoza-Hotels.d553248635640631221.Travel-Guide-Hotels) - [Villas in Santa Maria del Rio](https://www.expedia.com/Santa-Maria-Del-Rio-Villas.d6319948-aaVillas.Travel-Guide-Accommodation) - [Villa de Reyes Hotels](https://www.expedia.com/Villa-De-Reyes-Hotels.d6094960.Travel-Guide-Hotels) - [Hotels & Resorts for Couples in Santa Maria del Rio](https://www.expedia.com/Santa-Maria-Del-Rio-Hotels-Couples-Resorts-Hotels.0-0-d6319948-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Tierra Nueva Hotels](https://www.expedia.com/Tierra-Nueva-Hotels.d6346986.Travel-Guide-Hotels) - [Hotels near BMW Group Plant San Luis Potosi](https://www.expedia.com/BMW-Group-Plant-San-Luis-Potosi-Hotels.0-l884906833882533888-0.Travel-Guide-Filter-Hotels) - 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