Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Check Prices on Hotels in South Carolina Midlands

Tonight Jul 16 - Jul 17
This weekend Jul 19 - Jul 21
Next weekend Jul 26 - Jul 28

Featured South Carolina Midlands 4 Star Hotels

See all 636 Properties in South Carolina Midlands

Estimated price for 1 night/2 adults

The Ballantyne, A Luxury Collection Hotel, Charlotte
The Ballantyne, A Luxury Collection Hotel, Charlotte
4.0 out of 5.0 10000 Ballantyne Commons Pkwy, Charlotte, NC
Free Cancellation
4.7/5 (314 reviews)
$197/ night for 2 guests

We loved the gym!! The bathrooms are nice and I loved the smell of the shampoo and conditioner. The spa was relaxing and we enjoyed the sauna, pools, and hot tub. Room service was delicious and we felt like we had everything we needed. It was a nice stay!

Reviewed on Jul 2, 2019
Rosewood Manor House Bed and Breakfast
Rosewood Manor House Bed and Breakfast
4.0 out of 5.0 900 North Main Street, Marion, SC
4.9/5 (27 reviews)
$173/ night for 2 guests

I could fill my review with descriptions of this lavish property but am sure you will read dozens of illustrations of this stately piece of landmark history, so i would rather mention some of our personal interactions with inn keepers Gary and John. I was in town for a family wedding with my husband. ...

Reviewed on Jan 3, 2019

South Carolina Midlands Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in South Carolina Midlands, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the South Carolina Midlands 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in South Carolina Midlands. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in South Carolina Midlands, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star South Carolina Midlands hotels offer everything your heart desires.