Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Tenderloin 4 Star Hotels

See all 683 Hotels in Tenderloin
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
4.0 out of 5.0
3.3 out of 5 (8,248 reviews)
Great location near BART and the city center.Visited sister and business appointments near city hall.
  Dec 14, 2017

$105

$105
Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport

1333 Bayshore Hwy, Burlingame
4.5 out of 5.0
4.0 out of 5 (3,254 reviews)
Really GoodReally nice hotel and every way except the flat pillows. We stayed two nights and had two rooms. My dad, my wife, and myself all complaIned about the pillows. Even if you double them up they still fall flat then just squish up around your face. This may not bother some or you may be able to get different ...
  Dec 13, 2017

$99

$99
Sheraton Fisherman's Wharf Hotel

Sheraton Fisherman's Wharf Hotel

2500 Mason St, San Francisco
4.5 out of 5.0
3.8 out of 5 (3,924 reviews)
I was in town for my honeymoon Jim made sure our honeymoon stay was great. He went the extra mile with the complementary upgrade and honeymoon surprise that was sent to the room. I really enjoyed the stay and plan to comeback thanks!!
  Dec 16, 2017

$127

$127
Clift

Clift

495 Geary St, San Francisco
4.0 out of 5.0
4.1 out of 5 (3,445 reviews)
Very pleasant experience in this beautiful hotel, Room was bug and comfy. My only downside is the lack of coffee.tea machine in the room, not a deal breaker, but a nice plus.
  Dec 16, 2017

$159

$159
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.5 out of 5.0
4.3 out of 5 (6,524 reviews)
Great review Very pleased with my stay @the hotel. Great room, comfortable, clean, staff was great.
  Dec 15, 2017

$157

$157
Hyatt Regency San Francisco

Hyatt Regency San Francisco

5 Embarcadero Center, San Francisco
4.5 out of 5.0
4.3 out of 5 (3,168 reviews)
Nice hotel at Embarcadero The hotel is in a great location, where you go in a walking distance to the City sites. Cable car is a few steps away from the entrance. A lots a good restaurant in the area. The top floor had a great view where you can have a drink or snack and enjoy the beautiful view. We like this hotel for special ...
  Dec 14, 2017

$159

$159
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

335 Powell Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,377 reviews)
Good. We stayed in the older side of the building but had a nice view if union square. It was clean but of course old. It was also right next to the elevator but that did not bother us. AC did not seem to work but since it was cold it did not matter.
  Dec 14, 2017

$149

$149
Hotel Zoe San Francisco

Hotel Zoe San Francisco

425 North Point, San Francisco
4.5 out of 5.0
4.2 out of 5 (5,646 reviews)
Great stayThe experience at Zoe was great, we were greeted with wine, and our room was so cute and comfy. The bed was extremely big and comfy. Room service was quick and check out was so easy. All i can say is that be ready for that $100 hold on your card that takes 5 days to clear. Other than that it was ...
  Dec 15, 2017

$149

$149
Pier 2620 Hotel Fisherman's Wharf

Pier 2620 Hotel Fisherman's Wharf

2620 Jones Street, San Francisco
4.5 out of 5.0
4.2 out of 5 (4,093 reviews)
Great HotelLoved this place. Clean, great breakfast and close to EVERYTHING. I did not hear any noise like other people mentioned. I have 2 kids and they were not awaken at all during the night. We all slept amazing. You wont need a car, take Uber. Save the money on the parking fee at the hotel. We went all ...
  Dec 15, 2017

$161

$161
Grand Hyatt San Francisco Union Square

Grand Hyatt San Francisco Union Square

345 Stockton St, San Francisco
4.5 out of 5.0
4.4 out of 5 (3,346 reviews)
Great hotel. Tougher city. This is a great hotel. The staff were great. Helpful accommodating and professional. But San Francisco lately has a much rougher feel. As out of towners we could really see/feel a definite change. Still we had a great. long weekend. Thanks.
  Dec 14, 2017

$169

$169
Map

The outset of any trip starts with picking a spot. Tenderloin has become a popular choice with travelers because it offers so much to see and do. Location is everything, but that doesn't mean just the town you are flying into. When you want to make your next vacation especially memorable, it's all about where you stay each night.

Properties as Beautiful as Tenderloin

Tenderloin saw its fair share of visitors last year. Expedia's comment section features tips and tricks that may assist you in narrowing down your pick. The hotels found here aim to make your stay as enjoyable as your days and evenings exploring Tenderloin. You will never have to search long for a delectable lunch, to sustain your workout routine, or a refreshing dip during your visit, thanks to all these hotels offer. They aim to make their facilities and grounds welcoming from the moment you step out of your car and with every step throughout the hotel.

Rooms have been furnished to keep your utmost comfort in mind, with amenities like in-room coffee or tea, designer bathroom products, and ultra-comfortable bedding. So, lay back and decompress. Moreover, if you find that you are need of anything more, you can be confident the staff will work their hardest to ensure you continue to be satisfied during your time there. These accommodations are so lovely that you'll regret the day you have to return home.

Reserve a 4-Star Hotel in Tenderloin Today!

Your vacation to Tenderloin should be one that you'll recall for years to come, and booking a 4-star hotel will help make those memories fantastic. Of course, your trip should be focused on getting the most out of your destination. And getting the most often means giving yourself the best. Expedia offers 4-star hotels that allow you to do just that. Reserve with Expedia today!

Recently booked 4 Star Hotels in Tenderloin

The Marker San Francisco, a Joie de Vivre Hotel
4.5 out of 5.0
Last booking: 1 minute ago
Parc 55 San Francisco - A Hilton Hotel
4.5 out of 5.0
Last booking: 11 minutes ago
HTL 587, an Ascend Hotel Collection Member
2.5 out of 5.0
Last booking: 15 minutes ago
Serrano Hotel
4.5 out of 5.0
Last booking: 23 minutes ago
Handlery Union Square Hotel
4.0 out of 5.0
Last booking: 1 hour ago
Hilton San Francisco Union Square
4.5 out of 5.0
Last booking: 1 hour ago
Hotel Diva
4.0 out of 5.0
Last booking: 2 hours ago
Tilden Hotel
4.5 out of 5.0
Last booking: 3 hours ago
Clift
4.0 out of 5.0
Last booking: 3 hours ago