Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Texas Medical Center 4 Star Hotels

See all 567 Hotels in Texas Medical Center
Club Quarters Hotel in Houston

Club Quarters Hotel in Houston

720 Fannin Street, Houston
4.0 out of 5.0
4.0 out of 5 (1,370 reviews)
We had a few issues with the room (garbage disposal broken, not enough pillows) but as always the staff really went out of their way to remedy the situation.
  Sep 18, 2017

$85

$85
Hotel Derek Houston Galleria

Hotel Derek Houston Galleria

2525 West Loop S, Houston
4.0 out of 5.0
3.8 out of 5 (560 reviews)
Due for a decor refresh, showing its age.Experience was good, friendly staff and a comfortable bed and soft linens. Building decor (high style) is now showing its age with excessive wear and tear, needing some TLC and maintenance repair. Leaking A/C and flickering light fixtures. Towels were a little old as well. However, would still come ...
  Sep 21, 2017

$118

$118
Hilton Americas - Houston

Hilton Americas - Houston

1600 Lamar Street, Houston
4.0 out of 5.0
4.5 out of 5 (787 reviews)
Nice hotel in downtownComfortable walking distance to Minute Maid. We showed up late after an Astros game and all of the staff were very nice, informative and accommodating. There is a great sense of security with people posted at all entrances, elevators and throughout. Very clean grounds and room. Beds were very comfortable. ...
  Sep 18, 2017

$163

$163
Royal Sonesta Houston Galleria

Royal Sonesta Houston Galleria

2222 West Loop South, Houston
4.0 out of 5.0
4.4 out of 5 (552 reviews)
Great hotelThis was a great hotel. It is in great condition and the staff is excellent. My only complaint is they don't have a free parking option but as the same time I feel like my car was in a much more secure area so maybe it is worth 23 dollars a night for parking.
  Sep 7, 2017

$139

$139
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd, Houston
4.0 out of 5.0
3.7 out of 5 (111 reviews)
Nice HotelNice hotel and close to the galleria for shopping, the rooms are comfortable but the bathroom & kitchen do need a freshen up.
  Sep 12, 2017

$72

$72
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

5701 Main Street, Houston
4.0 out of 5.0
4.5 out of 5 (403 reviews)
Great location. Near everything!!!I will definitely recommend this hotel to anyone looking for a central location next to everything. Great views. Best HOUSTON Hotel!!!
  Sep 11, 2017

$250

$250
Hilton Houston Galleria Area

Hilton Houston Galleria Area

6780 Southwest Freeway, Houston
4.0 out of 5.0
3.9 out of 5 (231 reviews)
Nice hotel Close to oil corridor and galleria. Many restaurants to choose from in area
  Sep 21, 2017

$71

$71
The Whitehall Houston

The Whitehall Houston

1700 Smith St, Houston
4.0 out of 5.0
4.2 out of 5 (91 reviews)
Great customer service That African American custome service guy at the lobby who works during night has done exceptional customer service. That's quite great. I love their customer service in the hotel. Hotel room is spatial but there is no fridge. Very small bathroom design. Also I think it was a bit of dusty. We called ...
  Sep 16, 2017

$140

$140
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

2626 Sage Road, Houston
4.0 out of 5.0
4.5 out of 5 (224 reviews)
Great property, but expensive to park Beautiful, clean and modern hotel in the Galleria. Would have been a 5.0 if they didn't charge $35 to park overnight.
  Sep 8, 2017

$119

$119
The Westin Oaks Houston at the Galleria

The Westin Oaks Houston at the Galleria

5011 Westheimer Road, Houston
4.0 out of 5.0
4.0 out of 5 (286 reviews)
Nice hotel inside the mallNice hotel , clean , good location , secure, good staff , comfort bed , good size of the room .
  Sep 17, 2017

$119

$119
Map

The beginning of any well-deserved vacation gets started with picking a great spot. Texas Medical Center has been a popular destination with guests because it offers so much. However, "location, location, location" applies to more than just what city where your plane lands. When you want to make your next vacation extra special, it's all about where you wake up each morning.

Accommodations as Picturesque as the City

Texas Medical Center saw its fair share of visitors in the last year. Expedia's comment section includes comments that can assist you in narrowing down your pick. When you reserve a 4-star hotel you can breathe easy knowing that these properties strive to fulfill your needs. These hotels aim to make the facilities and grounds pleasing during your vacation. You will never need to search for a refreshing dip, nice lunch, or to keep up with your exercise routine.

Rooms have been fashioned to keep you as comfortable as possible, with amenities like specially designed bathroom products, ultra-comfortable bedding, and in-room tea or coffee. So, sit back and relax. Moreover, if you find yourself in need of anything more, you can rest easy the staff will do their best to ensure you continue to be happy during your time there. These hotels are so nice that you'll regret the day you have to leave.

Book a 4-Star Hotel in Texas Medical Center Today!

A getaway to Texas Medical Center should be one where you don't have to worry yourself about the little things. Of course, your trip should be focused on getting the most out of your destination. And getting the most often means giving yourself the best. Expedia offers 4-star hotels that allow you to do just that. Book through Expedia today!

Recently booked 4 Star Hotels in Texas Medical Center

Houston Marriott Medical Center
4.0 out of 5.0
Last booking: 3 hours ago
Hotel ZaZa Houston
4.0 out of 5.0
Last booking: 5 hours ago