An aerial view of a coastal town with clear blue waters, a marina, and a long pier extending into the sea.

Find 5 Star Hotels in Duck Key, FL from $194

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Duck Key 5 Star Hotels

Our top choices for Duck Key 5-star hotels

On the beach, sun loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,203 reviews)
"Great property, beautiful rooms and well maintained and friendly staff"
United States
Scarlet
$265 nightly
The price is $299
Aug 13 - Aug 14
Total with taxes and fees
Isla Bella Beach Resort & Spa
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Duck Key.
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd Marathon FL
$291 nightly
The price is $326 total per night from Jul 21 to Jul 22
$326 total
Jul 21 - Jul 22
Total with taxes and fees
8.2/10 Very Good! (1,016 reviews)
Still don't see what you're looking for?
See all properties in Duck Key.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Duck Key

Kayak through mangrove tunnels and spot colorful fish in the crystal-clear waters surrounding this tiny island paradise. Unwind at Hawks Cay Resort's saltwater lagoon or take a short trip to Marathon for the Turtle Hospital's educational tours.

See all hotels in Duck Key
A coastal city with a long bridge connecting to an island, surrounded by clear blue waters and numerous boats.

Top Duck Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

8/10 Good
"The staff was very professional, friendly, and efficient. The room was large and clean. Lots of choices of pools and activities. Be aware that everything costs something so the price you see on Expedia is way below the cost of the stay. For the cost of the stay, the value for price paid is way below what I expected for this resort. Charging for parking for the property is excessive knowing that it is exclusive for this property. It felt like an expensive MOTEL. While there are some terrific views, the room we choose based on online views was not we expected or thought we were getting. Overall, we were disappointed. I took my wife there for her 60th birthday, and in hindsight wish we had made a different choice. Food was meh and the drinks pricey, of, course, for the resort experience. No glassware in the room. For the price of the room, there should have been something more than dry powder creamer for the limited coffee service in the room - add some half and half creamers. We have stayed in much better resorts for less that offered more. I regret choosing this property and will not make the same mistake."
Geoff 2-night trip
Posted 18 hours ago
Isla Bella Beach Resort & Spa

Find out more about Duck Key

Ready to experience the next standard in luxury? We know you're thinking about it. Add even more enjoyment on your next trip to Duck Key by treating yourself to the best of the best when it comes to lodging. It's an ideal pairing. There's no reason to delay a getaway to Duck Key any longer. You'll join the multitudes of vacationers who have made Duck Key so fashionable in the last year. The accommodations in Duck Key also offer great customer service, averaging 3.9 in our ranking system, setting you up for a truly relaxing getaway. Don't wait any longer. Book one of Expedia's luxurious 5-star hotels in Duck Key and get ready to enjoy the getaway of a lifetime.

5-Star Hotels in Duck Key

You can expect high quality from your hotel. Exceptional customer care, spacious rooms, and fabulous spa offerings are all on offer. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in Duck Key offer great customer service, averaging 3.9 in our ranking system, giving you a lot to look forward to. How do you want to relax? 24-hour room service, so you can order that chocolate soufflé© in the wee hours of the morning? A mud wrap treatment that will leave you feeling refreshed and alive? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. Don't want to take our word for it? Then explore the 216 reviews various guests have left on Expedia and get to know these places.

Can't wait to get outside? Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Duck Key are waiting for you to relax after a busy day.

Your Getaway Starts Today

The results are in, and Duck Key 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Your great getaway is just a mouse-click away -- Expedia can help you land a great deal on accommodation. Decide on one of the 5-star hotels in Duck Key today and relax in luxe surroundings when you're ready.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Duck Key?
The amount you pay for a 5-star hotel in Duck Key depends on things such as when you want to go and the length of your escape. An insider tip for landing the best deal? Use our pricing filters to check out all of the available options for your selected dates.

  • Search for the lowest price per night from $194

What makes a hotel 5 stars in Duck Key?
Faultless guest service is integral to every 5-star hotel in Duck Key. From the moment you enter the lobby, staff attend to your every need, whether offering luggage assistance and storage or providing a nightly turn-down service. Also, hotels must feature superior amenities to be eligible for a 5-star rating. These can include luxury toiletries, a wellness center, swimming pools, fine dining restaurants and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Duck Key?
Use Expedia's filters to find an upscale retreat in Duck Key where most of what you need is included. Next, refine your results for properties that have a 5-star rating and are listed as "All inclusive." The most important thing on the to-do list at these stays? Pure enjoyment and indulgence.

Explore a world of travel with Expedia