Title: The Best 5 Star Hotels in Mission, SD  | Expedia.com

[Mission Travel Guide](https://expedia.com/Mission.dx181132)[Hotels in Mission](https://expedia.com/Mission-Hotels.d181132.Travel-Guide-Hotels)[Vacation Rentals in Mission](https://expedia.com/Mission-Vacation-Rentals.d181132.Travel-Guide-VacationRentals)[Flights to Mission](https://expedia.com/Cheap-Flights-To-Mission.d181132.Travel-Guide-Flights)[Car Rentals in Mission](https://expedia.com/Car-Rentals-In-Mission.d181132.Car-Rental-Guide)[Mission Vacation Packages](https://expedia.com/Mission.d181132.Destination-Travel-Guides)

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## Check availability on Mission 5 Star Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.com/Hotel-Search?regionId=181132&startDate=2026-02-05&endDate=2026-02-06&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.com/Hotel-Search?regionId=181132&startDate=2026-02-06&endDate=2026-02-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.com/Hotel-Search?regionId=181132&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=181132&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Top Mission Hotel Reviews

## Find out more about Mission

Ready for an incredible adventure? Add even more luxury on your next trip to Mission by treating yourself to the best of the best when it comes to lodging. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mission so popular in the last year. There's no reason to delay a getaway to Mission any longer. Besides, the hotels in this area are known for customer service, so you know you'll want for nothing during your getaway. Our 5-star hotels in Mission are the perfect places to relax in during your next escape. Don't wait any longer!

### Get a Great Deal on 5-Star Hotels in Mission

Don't be afraid to demand the best service from your hotel, along with the best conditions. Excellent customer care, granite-tiled bathrooms, and fabulous spa offerings are all on offer. You're sure to find exactly the accommodation you need. Not only that, the hotels in this area receive high marks for guest services, so you know you'll be well cared for during your getaway. How do you want to relax? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A mud wrap treatment that will leave you feeling like a million bucks? Butler services? No matter what you want on a perfect getaway, you're bound to find it here. 

You won't sleep and order room service the entire time, though. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Mission are the perfect place to rest up after an exciting day. Ready to learn more? Plenty of visitors recommend this location. 

### Your Getaway Starts Today

The results are in, and Mission 5-star hotels are the place to be when you book your next vacation. Additionally, these accommodations are highly rated -- 100% of visitors recommended 5-star hotels in Mission! It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Select one of Expedia's Mission 5-star hotels today and relax in the lap of luxury at your convenience.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Mission?

> - Search for the lowest price per night

### What makes a hotel 5 stars in Mission?

### Are there any 5-star all-inclusive resorts in Mission?

## Explore a world of travel with Expedia

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