Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Featured Ortygia 5 Star Hotels

See all 109 Hotels in Ortygia
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12, Syracuse
5.0 out of 5.0
4.4 out of 5 (143 reviews)
Grand hotel in OrtegiaPerfectly located grand hotel near entrance to Ortigia Island. Helpful and friendly staff. Rooftop bar and restaurant (also used for breakfast). All Ortigia attractions and old town destinations are reachable in 5-15 min walk.
  Sep 29, 2017


Des Etrangers Hotel & SPA

Des Etrangers Hotel & SPA

Passeggio Adorno 10/12, Syracuse
5.0 out of 5.0
4.0 out of 5 (226 reviews)
Great stylish hotel close to all the sights on the island, roof bar was a highlight.
  Oct 1, 2017



5 stars in Ortygia

Search for hotels in Ortygia on Expedia. You can easily find your hotels in Ortygia using one of the methods below:

  • View our selection of featured hotels in Ortygia
  • Use the map to find hotels in the Ortygia area you prefer
  • Use the filters to see hotels in a specific area of Ortygia, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Ortygia
  • Enter your travel dates to view the best deals on hotels in Ortygia - while they last

Recently booked 5 Star Hotels in Ortygia

Grand Hotel Ortigia Siracusa
5.0 out of 5.0
Last booking: 1 hour ago