Find 5 Star Hotels in Panama City from $87

Most hotels are fully refundable. Because flexibility matters.

Save 10% or more on over 100,000 hotels worldwide as a One Key member.

Search over 2.9 million properties and 550 airlines worldwide.

Compare Panama City 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Crowne Plaza Panama Airport, an IHG Hotel

Crowne Plaza Panama Airport, an IHG Hotel

Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
The price is $118 per night from May 3 to May 4
$118
$130 total
includes taxes & fees
May 3 - May 4
8.2/10 Very Good! (1,827 reviews)
Still don't see what you're looking for?
See all properties in Panama City.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

There's nothing wrong with enjoying the finer things in life. Why not ask for the best during your trip to Panama City? There's no reason to delay a getaway to Panama City any longer. In fact, the sheer number of visitors to Panama City has shot up over the last year. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. What are you waiting for? Book one of Expedia's luxurious 5-star hotels in Panama City and get ready to enjoy the getaway of a lifetime.

5-Star Hotels in Panama City

You'll have a wonderful time at one of these 5-star hotels. Spa treatments, delicious meals, and personalized service are all at your fingertips. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A mud wrap treatment that will leave you feeling outstanding? 24-hour room service, so you can order that chocolate soufflé© in the wee hours of the morning? A deep-tissue massage to help your cares fall away?

Ready for experiences outside your hotel room? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Panama City are waiting for you to rest up after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Panama City 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. This is a great time to find 5-star hotel deals in @region! It's time to plan your next great escape. Opt for one of the 5-star hotels in Panama City today and decompress in total tranquility tomorrow.

Frequently asked questions

What are the best 5-star hotels in Panama City?
Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are some of the top 5-star hotels in Panama City, based on reviews by our customers. These swanky hotels rate highly for things like their location, amenities and guest service standards. Pick your favorite and enjoy the best of it all.
How much does it cost to stay in a 5-star hotel in Panama City?
The amount you pay for a 5-star hotel in Panama City depends on factors such as when you plan to travel and the length of your escape. An insider tip for landing an awesome deal? Use our pricing filters to check out all of the available hotels for your preferred dates.

  • Search for the lowest price per night from $87

What makes a hotel 5 stars in Panama City?
In Panama City, a hotel needs to provide a specific amount of upscale conveniences to earn a 5-star rating. These can include on-site gyms, saunas and spas, gourmet restaurants, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their guest-focused service. You’ll enjoy things like nightly turn-down services, concierge services and in-room massages. Some may even offer thoughtful touches like welcome gifts.
Are there any 5-star all-inclusive resorts in Panama City?
Our filter tool is the quickest way to narrow down what you’re looking for. Check the “All inclusive” and “5-star” boxes to show the most luxurious hotels in Panama City where your room, meals, activities and entertainment are included in the upfront price. At these stays, your vacation is pure indulgence from the moment you put down your suitcase.
What are the top 5-star spa hotels in Panama City?
Recharge your batteries with a decadent massage and other rejuvenating treatments at Waldorf Astoria Panama. It’s one of Panama City’s most popular 5-star spa escapes. W Panama and Bristol Panama, a Registry Collection Hotel also blend upmarket accommodations with a range of wellness therapies.
Are there any 5-star vacation rentals in Panama City?
There are no 5-star vacation rentals in Panama City on our site, but there are a range of other highly rated properties worth looking into. Scan through our vacation rentals in Panama City to book the perfect place for your getaway.
Are there any 5-star hotels in downtown Panama City?
Base yourself at Bristol Panama, a Registry Collection Hotel and take advantage of being near the sights and sounds of downtown Panama City.
What are the top 5-star hotels near Marcos A. Gelabert Intl. Airport (PAC)?
Take the stress out of early or late flights and book Villa Palma Boutique Hotel for your next visit to Panama City. Conveniently located 4 mi southeast of Marcos A. Gelabert Intl. Airport (PAC), you’ll look forward to having extra time in your schedule to indulge in the quality perks this 5-star escape has to offer.

Recent reviews of Panama City hotels
Expedia verified reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5/5 Excellent
"We went for our anniversary and it was great. The breakfast was amazing. They had so many options. It was close to everything which was a big plus. Great staff and great facility. Loved it!"
A verified traveler stayed at Hotel Riu Plaza Panama
Posted 2 days ago
Hotel Riu Plaza Panama