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Featured Panama 5 Star Hotels

See all 528 Hotels in Panama
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,103 reviews)
Nice hotel no beachNice hotel however the pool is between 2 towers and there is no more sun at 1PM. Pool is not heated and all the guests complained about it
  Feb 23, 2018
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (433 reviews)
Bristol Panama rivals the Ritz CarltonMy experience at the hotel was 100% fantastic. I felt like I was in paradise as every type of serve was of superb quality. Facilities like the gym, restaurant/lounge, spa, rooms, and pool area were clean and highly functioning.
  Feb 24, 2018
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (434 reviews)
Great stay. Staff were very accommodating. Could use a exercise bike in the gym besides the treadmills. Street was being dug up so it was annoying for taxis to get here. Pool nice but a little small
  Feb 22, 2018
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (268 reviews)
Busy hotel in main thoroughfare This hotel was always very busy. There is a casino downstairs. The decor was very contemporary but the carpet in the rooms looked like they needed to be vacuumed. The staff was friendly and helpful couldn’t ask for better staff. The location of hotel was exactly where we wanted it. It is in center ...
  Jan 30, 2018
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (247 reviews)
Nice hotels with great amenitiesVery good experience me and my wife in our first time in Panama.
  Feb 21, 2018
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
5.0 out of 5.0
4.2 out of 5 (263 reviews)
Very nice hotel Very clean, just as expected. A lot of parkings. And valet parking is included. It has stores inside if you need anything and a couple a bank cash dispensers. The restaurant is also really good.
  Jan 28, 2018
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
5.0 out of 5.0
4.7 out of 5 (118 reviews)
Central Location in Old TownThis beautifully renovated hotel is an icon of the glory days of old. It is well situated in the area of Panama City called Casco Viejo which is the old original Panama City, so it's good for walking tours. There are many nice outdoor restaurants in Viejo to enjoy the warm weather. The hotel has ...
  Feb 11, 2018
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (303 reviews)
Our vacation at Westin Playa BonitaOf course the beach is a non-factor on this side of Panama. We stayed off the beach. Having an ocean front room was great but the ocean water was very murky and filled with quite a few large oil tankers in a distance. The hotel grounds and rooms were 5 stars, but the amenities were limited due to ...
  Feb 19, 2018
Panama Marriott Hotel

Panama Marriott Hotel

52nd St. and Ricardo Arias, Panama City
5.0 out of 5.0
4.4 out of 5 (241 reviews)
Great hotel Great location Nice hotel and it is centrally located in Panama City.
  Dec 16, 2017
W Panama

W Panama

Calle Aquilino de la Guardia & Calle 50, Panama City
5.0 out of 5.0
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There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Panama by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. After all, this is one of the Top 100 locations in Expedia's portfolio! You'll join the multitudes of vacationers who have made Panama so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Our 5-star hotels in Panama are the perfect places to relax in during your next escape.

5-Star Hotels in Panama

You'll have a fantastic time at one of these 5-star hotels. Excellent service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama are the perfect place to rest up after a busy day.

Make Your Escape

The results are in, and Panama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of our Panama 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

Recently booked 5 Star Hotels in Panama

Melia Panama Canal
4.5 out of 5.0
Last booking: 2 minutes ago
Riande Aeropuerto Hotel & Casino
4.5 out of 5.0
Last booking: 7 minutes ago
Bristol Panama
5.0 out of 5.0
Last booking: 17 minutes ago
Wyndham Panama Albrook Mall
4.5 out of 5.0
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Gamboa Rainforest Resort
4.0 out of 5.0
Last booking: 1 hour ago
Mar Y Oro
4.0 out of 5.0
Last booking: 1 hour ago
Hotel Versalles
3.5 out of 5.0
Last booking: 1 hour ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 1 hour ago
The Beach House
3.5 out of 5.0
Last booking: 2 hours ago