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Featured Panama 5 Star Hotels

See all 499 Hotels in Panama
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
5.0 out of 5.0
4.3 out of 5 (2,193 reviews)
Excellent veiwNice location with excellent veiws. Great breakfast buffet
  Dec 11, 2017

$130

$130
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,042 reviews)
Great locationGreat location. Room OK, nice view. Shower needed some maintenance (minor leaks) but overall it was OK. Friendly and helpful staff.
  Dec 12, 2017

$149

$149
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (408 reviews)
We had a good experience, all the staff was friendly and helpful. We went once to have breakfast and it was of poor quality and very expensive.
  Dec 11, 2017

$127

$127
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (399 reviews)
Beautiful and luxury hotelVery clean, big rooms, excellent service, close to everywhere
  Dec 5, 2017

$178

$178
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (223 reviews)
Very pretty hotel and clean hotel in great location ,will tell other people about this hotel
  Dec 10, 2017

$132

$132
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (251 reviews)
Nice hotel, wonderful view, excellent locationNice hotel, wonderful view, excellent location, great rooms, beautiful lobby and bsr
  Nov 22, 2017

$129

$129
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (282 reviews)
Westin is the way to go.The hotel and the room were clean. The staff was very friendly and we were able to get by with our limited Spanish speaking skills.
  Nov 2, 2017

$173

$173
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
5.0 out of 5.0
4.6 out of 5 (114 reviews)
Lovely and ultra comfortable hotel in the heart of Old Town.
  Nov 27, 2017

$260

$260
Panama Marriott Hotel

Panama Marriott Hotel

52nd St. and Ricardo Arias, Panama City
5.0 out of 5.0
4.4 out of 5 (237 reviews)
Convenient city location I was able to pre-check in on my phone. Room was ready for us.
  Dec 7, 2017

$88

$88
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
5.0 out of 5.0
4.2 out of 5 (249 reviews)
Excelente place for rest after partyExcelente place for rest after party, and the morning breakfast very good
  Nov 19, 2017

$115

$115
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There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Panama by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. After all, this is one of the Top 100 locations in Expedia's portfolio! You'll join the multitudes of vacationers who have made Panama so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Our 5-star hotels in Panama are the perfect places to relax in during your next escape.

5-Star Hotels in Panama

You'll have a fantastic time at one of these 5-star hotels. Excellent service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama are the perfect place to rest up after a busy day.

Make Your Escape

The results are in, and Panama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of our Panama 5-star hotels today and soothe yourself in luxe surroundings tomorrow.