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Featured Panama 5 Star Hotels

See all 525 Hotels in Panama
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,095 reviews)
It was a wonderful experience, everything was great. Room was clean, food was great, friendly staff. Great location.
  Feb 13, 2018

$179

$179
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (428 reviews)
Check-in staff need trainingCheck-in was rather abrupt as we were not told about hotel facilities, etc. There was a shortage of bellhops and we were directed to the wrong tower but thankfully we were intercepted by an excellent young staff member who took our luggage and personally escorted us to our room and then explained ...
  Feb 7, 2018

$179

$179
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (433 reviews)
Best hotel in Panama CityExcellent service, comfortable rooms, in a district with a lot of restaurants and nightlife.
  Feb 10, 2018

$147

$147
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (267 reviews)
Busy hotel in main thoroughfare This hotel was always very busy. There is a casino downstairs. The decor was very contemporary but the carpet in the rooms looked like they needed to be vacuumed. The staff was friendly and helpful couldn’t ask for better staff. The location of hotel was exactly where we wanted it. It is in center ...
  Jan 30, 2018

$139

$139
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (245 reviews)
modern hotel, bit busy an noisy at times when coming in and out of the lobby
  Jan 27, 2018

$149

$149
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
5.0 out of 5.0
4.1 out of 5 (260 reviews)
Very nice hotel Very clean, just as expected. A lot of parkings. And valet parking is included. It has stores inside if you need anything and a couple a bank cash dispensers. The restaurant is also really good.
  Jan 28, 2018

$115

$115
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
5.0 out of 5.0
4.7 out of 5 (117 reviews)
Central Location in Old TownThis beautifully renovated hotel is an icon of the glory days of old. It is well situated in the area of Panama City called Casco Viejo which is the old original Panama City, so it's good for walking tours. There are many nice outdoor restaurants in Viejo to enjoy the warm weather. The hotel has ...
  Feb 11, 2018

$260

$260
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (301 reviews)
huge resort facing the pacificI am not usually a fan of big resorts with multiple pools, enormous lobby, office high-rise feel but for a 3-night stay it was very convenient, the weather was wonderful (rain stops in panama from january to march). The staff is very warm and helpful, not pushy at all (except to take away your plates ...
  Feb 14, 2018

$169

$169
Manrey Boutique Hotel

Manrey Boutique Hotel

Calle Uruguay y Calle 48, Panama City
5.0 out of 5.0
3.8 out of 5 (252 reviews)
Service is goodGreat location for night life. Several Discos and nice restruant walking distance.
  Oct 19, 2015
W Panama

W Panama

Calle Aquilino de la Guardia & Calle 50, Panama City
5.0 out of 5.0

$149

$149

There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Panama by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. After all, this is one of the Top 100 locations in Expedia's portfolio! You'll join the multitudes of vacationers who have made Panama so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Our 5-star hotels in Panama are the perfect places to relax in during your next escape.

5-Star Hotels in Panama

You'll have a fantastic time at one of these 5-star hotels. Excellent service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama are the perfect place to rest up after a busy day.

Make Your Escape

The results are in, and Panama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of our Panama 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

Recently booked 5 Star Hotels in Panama

The Executive Hotel
4.0 out of 5.0
Last booking: 14 minutes ago
Express Inn Panama International Airport Hostel
2.0 out of 5.0
Last booking: 18 minutes ago
Grand International Hotel
3.5 out of 5.0
Last booking: 19 minutes ago
Continental Hotel & Casino
4.5 out of 5.0
Last booking: 27 minutes ago
Sercotel Panama Princess
4.0 out of 5.0
Last booking: 57 minutes ago
Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 1 hour ago
Wyndham Panama Albrook Mall
4.5 out of 5.0
Last booking: 1 hour ago
Tropical Suites Hotel
4.0 out of 5.0
Last booking: 1 hour ago
TRYP by Wyndham Panamá Centro
4.0 out of 5.0
Last booking: 1 hour ago