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Featured Panama 5 Star Hotels

See all 501 Hotels in Panama
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
5.0 out of 5.0
4.3 out of 5 (2,195 reviews)
Excellent veiwNice location with excellent veiws. Great breakfast buffet
  Dec 11, 2017

$130

$130
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,043 reviews)
Wonderful stay! We had a wonderful stay at the Trump Tower. The view from our balcony was stunning. We enjoyed having breakfast on the balcony in the mornings. The hotel is conveniently located in an area where it takes only a short taxi ride to get to most places we want to visit. Hotel staff was friendly and helpful. ...
  Dec 14, 2017

$149

$149
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (408 reviews)
We had a good experience, all the staff was friendly and helpful. We went once to have breakfast and it was of poor quality and very expensive.
  Dec 11, 2017

$127

$127
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (401 reviews)
Lovely accommodations in city centerThe hotel is beautiful and the staff is great. We really enjoyed our night there. We walked to a nearby Spanish restaurant that had amazing food and service, too.
  Dec 12, 2017

$178

$178
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (223 reviews)
Very pretty hotel and clean hotel in great location ,will tell other people about this hotel
  Dec 10, 2017

$132

$132
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (251 reviews)
Nice hotel, wonderful view, excellent locationNice hotel, wonderful view, excellent location, great rooms, beautiful lobby and bsr
  Nov 22, 2017

$129

$129
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (283 reviews)
Very nice hotelAfter spending five days in Panama City, we transferred to Westin at Playa Bonita (approximately 30 miles from Panama City). With respect to the location, we knew what to expect. Hence, there were no surprises. Hotel is in a very secluded area (i.e. rain forest at one side and a narrow sandy beach ...
  Dec 14, 2017

$173

$173
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
5.0 out of 5.0
4.6 out of 5 (114 reviews)
Lovely and ultra comfortable hotel in the heart of Old Town.
  Nov 27, 2017

$260

$260
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
5.0 out of 5.0
4.2 out of 5 (251 reviews)
Excelente place for rest after partyExcelente place for rest after party, and the morning breakfast very good
  Nov 19, 2017

$115

$115
Manrey Boutique Hotel

Manrey Boutique Hotel

Calle Uruguay y Calle 48, Panama City
5.0 out of 5.0
3.8 out of 5 (252 reviews)
Service is goodGreat location for night life. Several Discos and nice restruant walking distance.
  Oct 19, 2015
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There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Panama by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. After all, this is one of the Top 100 locations in Expedia's portfolio! You'll join the multitudes of vacationers who have made Panama so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Our 5-star hotels in Panama are the perfect places to relax in during your next escape.

5-Star Hotels in Panama

You'll have a fantastic time at one of these 5-star hotels. Excellent service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama are the perfect place to rest up after a busy day.

Make Your Escape

The results are in, and Panama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of our Panama 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

Recently booked 5 Star Hotels in Panama

Crowne Plaza Panama Airport
4.5 out of 5.0
Last booking: 19 minutes ago
The Haven and Spa
4.0 out of 5.0
Last booking: 25 minutes ago
Waldorf Astoria Panama
5.0 out of 5.0
Last booking: 1 hour ago
Crowne Plaza Panama
4.0 out of 5.0
Last booking: 1 hour ago
RIU Plaza Panama
4.5 out of 5.0
Last booking: 1 hour ago
Occidental Panamá City
4.5 out of 5.0
Last booking: 1 hour ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 1 hour ago
AC Hotel by Marriott Panama City
4.0 out of 5.0
Last booking: 1 hour ago
Riande Aeropuerto Hotel & Casino
4.5 out of 5.0
Last booking: 1 hour ago