Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Check prices on hotels in Panama

Tonight Tonight Jun 23 - Jun 24
This weekend This weekend Jun 29 - Jul 1
Next weekend Next weekend Jul 6 - Jul 8
Map

There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Panama by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. After all, this is one of the Top 100 locations in Expedia's portfolio! You'll join the multitudes of vacationers who have made Panama so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Our 5-star hotels in Panama are the perfect places to relax in during your next escape.

5-Star Hotels in Panama

You'll have a fantastic time at one of these 5-star hotels. Excellent service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama are the perfect place to rest up after a busy day.

Make Your Escape

The results are in, and Panama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of our Panama 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

Recently booked 5 Star Hotels in Panama

Hotel Coral Suites
3.5 out of 5.0
Last booking: 21 hours ago
Metro Hotel Panama
3.5 out of 5.0
Last booking: 21 hours ago
Country Inn & Suites by Radisson, Panama Canal, Panama
3.5 out of 5.0
Last booking: 21 hours ago
The Westin Panama
4.0 out of 5.0
Last booking: 21 hours ago
Crowne Plaza Panama Airport
4.0 out of 5.0
Last booking: 22 hours ago
Sortis Hotel, Spa & Casino, Autograph Collection
4.5 out of 5.0
Last booking: 22 hours ago
Hotel Covadonga
2.0 out of 5.0
Last booking: 22 hours ago
Radisson Decapolis Panama City
4.0 out of 5.0
Last booking: 22 hours ago
Plaza Paitilla Inn Hotel
3.5 out of 5.0
Last booking: 23 hours ago