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Featured Panama 5 Star Hotels

See all 522 Hotels in Panama
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
5.0 out of 5.0
4.3 out of 5 (2,223 reviews)
Entertaining hotelExcellent stay. Would recommend hotel. Very nice pool area and great on premise bars. Restaurant staff was very attentative and friendly. Particularly a young waitress by the name of Andrea. She made sure my fiancée and l had an excellent dining experience.
  Jan 20, 2018

$150

$150
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,078 reviews)
Great Stay!Amazing views from the balcony and great room stocked with everything you could need. Very comfortable beds. The infinity pool overlooking the ocean was the highlight!
  Jan 19, 2018

$215

$215
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (417 reviews)
A great hotel in Panama City!We felt pampered at the Bristol! The location was great, the room was superb, the beds were wonderful, the breakfast was really good in a beautiful setting - we really felt that we were on holidays at the Bristol. We could not find fault with anything and would go back anytime, if just for the hotel ...
  Jan 18, 2018

$169

$169
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (423 reviews)
Very nice hotelIt was great. Very comfortable room. Room service was very good. Staff is super friendly. Check in was super quick
  Jan 19, 2018

$149

$149
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (257 reviews)
A dream hotelGreat room and a view. Nice top of the line bathroom and bed. The Gym was a dream for any Gym lover
  Jan 17, 2018

$149

$149
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (240 reviews)
Great hotel and great stay This is a great hotel - obarrio is not the most centrally located if you want touristic places but it’s definitely close enough to be convenient and far enough away to not feel like you’re staying in a touristy place. The hotel is big and has tons of things - very nice. The only issue I had was that ...
  Jan 5, 2018

$159

$159
American Trade Hotel

American Trade Hotel

Plaza Herrera Casco Viejo, Panama City
5.0 out of 5.0
4.6 out of 5 (114 reviews)
Lovely and ultra comfortable hotel in the heart of Old Town.
  Nov 27, 2017

$246

$246
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
5.0 out of 5.0
4.1 out of 5 (257 reviews)
Excellent hotel at a great locationI am an regular client of this hotel since 85, when it was called the Cesar Park hotel. My experience has always been very positive, good and friendly service, great installations. Ample, clean and quite rooms.
  Dec 15, 2017

$115

$115
Panama Marriott Hotel

Panama Marriott Hotel

52nd St. and Ricardo Arias, Panama City
5.0 out of 5.0
4.4 out of 5 (240 reviews)
Great hotel Great location Nice hotel and it is centrally located in Panama City.
  Dec 16, 2017

$131

$131
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.1 out of 5 (288 reviews)
Very nice hotel with a friendly, helpful staff.This was my first stay in Panama City, so when I was looking for a hotel, I only had past experiences with other Westin properties as my guide and I was NOT disappointed! This is a very nice, clean, friendly place to stay. I would definitely go back again.
  Dec 19, 2017

$212

$212
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There's nothing wrong with enjoying the finer things in life. Add an extra layer of luxury on your next trip to Panama by treating yourself to the best of the best when it comes to lodging. It's an ideal fusion. After all, this is one of the Top 100 locations in Expedia's portfolio! You'll join the multitudes of vacationers who have made Panama so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Our 5-star hotels in Panama are the perfect places to relax in during your next escape.

5-Star Hotels in Panama

You'll have a fantastic time at one of these 5-star hotels. Excellent service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Panama are the perfect place to rest up after a busy day.

Make Your Escape

The results are in, and Panama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Don't put off your dream vacation any longer -- this is a great time to find 5-star hotel deals in @region! Select one of our Panama 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

Recently booked 5 Star Hotels in Panama

Sheraton Grand Panama
5.0 out of 5.0
Last booking: 1 hour ago
Riande Aeropuerto Hotel & Casino
4.5 out of 5.0
Last booking: 2 hours ago
RIU Plaza Panama
4.0 out of 5.0
Last booking: 3 hours ago
Hotel Palma Royale
4.0 out of 5.0
Last booking: 3 hours ago
Le Meridien Panama
4.5 out of 5.0
Last booking: 4 hours ago
Wyndham Panama Albrook Mall
4.5 out of 5.0
Last booking: 5 hours ago
The Westin Playa Bonita Panama
5.0 out of 5.0
Last booking: 5 hours ago
Radisson Summit Hotel and Golf Panama
4.5 out of 5.0
Last booking: 6 hours ago
Hyatt Place Panama City/Downtown
4.0 out of 5.0
Last booking: 7 hours ago