Beginning of main content

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Francisco 5 Star Hotels

See all 543 Hotels in San Francisco
Fairmont San Francisco

Fairmont San Francisco

950 Mason Street Atop Nob Hill, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,880 reviews)
Beautiful HotelThis hotel is gorgeous. My flight was delayed due to weather and my travel agent called to see if they would upgrade me due to the fact that I was losing a night. They did. My room was absolutely stunning. The young man at the desk was helpful and kind at 330am when I arrived. I was a tad disappointed ...
  Feb 16, 2018

$220

$220
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

2 New Montgomery St, San Francisco
5.0 out of 5.0
4.5 out of 5 (3,083 reviews)
Nice hotel excelente ubicación nice crews rooms cleaned fast and good room service
  Feb 16, 2018

$205

$205
Omni San Francisco Hotel

Omni San Francisco Hotel

500 California St, San Francisco
5.0 out of 5.0
4.7 out of 5 (3,368 reviews)
We got in late and the staff were so helpful and they even gave us extra water so we did t get charged for the room water and then they gave us a larger room than we had booked and the room was huge and really nice and clean.
  Feb 19, 2018

$201

$201
The Scarlet Huntington Hotel

The Scarlet Huntington Hotel

1075 California St, San Francisco
5.0 out of 5.0
4.6 out of 5 (1,570 reviews)
Great location I love old world charm. This hotel is gorgeous. The room was beautiful & quaint. Great shower!! The complimentary town car is a wonderful touch. We are definitely staying here again. The hotel bar is a neighborhood watering hole, great for meeting locals. We sat in the park across the street, soaked ...
  Feb 16, 2018

$292

$292
InterContinental San Francisco

InterContinental San Francisco

888 Howard Street, San Francisco
5.0 out of 5.0
4.5 out of 5 (2,012 reviews)
WiFi not free$14.95 for wi-fi, which is ridiculous. Otherwise, pretty decent place to stay.
  Feb 11, 2018

$170

$170
Loews Regency San Francisco

Loews Regency San Francisco

222 Sansome St, San Francisco
5.0 out of 5.0
4.6 out of 5 (400 reviews)
Great hotel staff, perfect views of bay , nice room.I would have given complete 5 stars if their sky deck was open. It was closed for maintenance but otherwise , very good hotel .
  Feb 9, 2018

$332

$332
The Ritz-Carlton, San Francisco

The Ritz-Carlton, San Francisco

600 Stockton St, San Francisco
5.0 out of 5.0
4.5 out of 5 (782 reviews)
Awesome service. Beautiful hotel. Will stay there again.
  Feb 12, 2018

$379

$379
Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco

757 Market St, San Francisco
5.0 out of 5.0
4.5 out of 5 (483 reviews)
Amazing place and amazing staff.So glad we chose the four seasons.
  Dec 28, 2017

$425

$425
The Ritz-Carlton, Half Moon Bay

The Ritz-Carlton, Half Moon Bay

1 Miramontes Point Rd, Half Moon Bay
5.0 out of 5.0
4.6 out of 5 (373 reviews)
Beautiful Celebration Starting a new journey in my life this was a personal celebration for me. I now walk this earth alone but am blessed with a beautiful life.
  Feb 12, 2018

$779

$779
The St. Regis San Francisco

The St. Regis San Francisco

125 3rd St, San Francisco
5.0 out of 5.0
4.7 out of 5 (323 reviews)
No hot SPA near the swimming pool is a little disappointment for me, but everything else is just St. Regis.
  Feb 5, 2018

$425

$425
Map

Treat your every desire on your upcoming break. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made San Francisco so popular in the last year. Come see what all the excitement is about. We should also mention, the hotels in this area are known for guest services, so you know you'll be well cared for during your getaway. Reserve one of our 5-star hotels in San Francisco and indulge in the finer things in life for a while. What are you waiting for?

Get a Great Deal on 5-Star Hotels in San Francisco

Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Highly-rated eateries, exceptional customer care, and fabulous spa offerings are waiting for you. We have a huge number of hotels in the region, and all of them offer awesome amenities. Additionally, the hotels in this area receive fantastic marks for guest services, so you know you'll be looked after during your getaway. What kind of amenities will make your stay a wonderful one? A mud wrap treatment that will leave you feeling refreshed and alive? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A Swedish massage to help your cares fall away? Want to see for yourself? Then explore the 13,157 reviews various guests have left on Expedia and get to know these places.

Can't wait to get outside? You're in luck. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals -- they'll be happy to sit down for a pint or a cuppa.

Your Getaway Starts Today

The results are in, and San Francisco 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Your great getaway is just a mouse-click away -- this is a great time to find 5-star hotel deals in @region! Choose one of Expedia's San Francisco 5-star hotels today and soothe yourself in complete comfort tomorrow.

Recently booked 5 Star Hotels in San Francisco

Galleria Park Hotel, a Joie de Vivre Boutique Hotel
4.5 out of 5.0
Last booking: 16 minutes ago
Best Western Plus El Rancho Inn
3.5 out of 5.0
Last booking: 27 minutes ago
Castle Inn
2.0 out of 5.0
Last booking: 30 minutes ago
Hotel Zelos San Francisco
4.5 out of 5.0
Last booking: 37 minutes ago
Holiday Inn Express San Francisco-Airport North
3.0 out of 5.0
Last booking: 38 minutes ago
Calista Organic Hotel
3.5 out of 5.0
Last booking: 38 minutes ago
Pacific Inn of Redwood City
3.0 out of 5.0
Last booking: 43 minutes ago
Comfort Inn by the Bay
3.0 out of 5.0
Last booking: 1 hour ago
Coral Reef Inn & Suites
3.0 out of 5.0
Last booking: 1 hour ago