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Find 5 Star Hotels in Seneca, SC from $122

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Compare Seneca 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Seneca.
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

110 Sloan St, Clemson, SC
The price is $169 per night from May 12 to May 13
$169
$188 total
includes taxes & fees
May 12 - May 13
9.8/10 Exceptional! (221 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pamper your every whim on your upcoming break. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Seneca so popular in the last year. There's no reason to delay a getaway to Seneca any longer. Besides, the hotels in this area receive high marks for customer service, so you know you'll want for nothing during your getaway. Our 5-star hotels in Seneca are the perfect places to relax in when you really need to escape. What are you waiting for?

Book the Best Seneca 5-Star Hotels

Don't be afraid to be pampered during your trip, along with pristine rooms. Michelin-starred restaurants, excellent customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to lay your head at night. What creature comforts do you want in your lodging? A deep-tissue massage to help your cares fall away? A concierge to help you pick out your next adventure? Comfortable beds, lip-smacking main courses, and even spectacular views...these hotels will leave you amazed.

But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Seneca are waiting for you to relax after an exciting day. Ready to learn more? Read the review section and see what previous visitors have said. You're sure to find exactly what you're looking for!

Your Getaway Starts Today

The results are in, and Seneca 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Choose one of Expedia's Seneca 5-star hotels today and soothe yourself in complete comfort tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Seneca?
The amount you pay for a 5-star hotel in Seneca depends on factors such as when you plan to travel and the length of your trip. A top tip for landing the best deal? Use our pricing filters to check out all of the available options for your chosen dates.

  • Search for the lowest price per night from $122

What makes a hotel 5 stars in Seneca?
Impeccable guest service is the defining feature of every 5-star hotel in Seneca. From the minute you step through the door, staff attend to your every whim, whether answering room service calls 24/7 or providing a nightly turn-down service. On top of that, hotels must feature superior conveniences to be considered for a 5-star rating. These can include luxury bath products, on-site spa facilities, swimming pools, gourmet kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Seneca?
Find a luxury getaway that includes your lodging, meals, bar and entertainment in Seneca with our filters. Search for properties rated 5 stars and select the “All inclusive” filter. Make sure you check what’s included in the upfront price. That way, you’re ready to take advantage of all the premium perks when you get there.
Are there any 5-star vacation rentals in Seneca?
Our site doesn’t have any 5-star vacation rentals in Seneca. However, you can still find some top-rated stays where the only item on your itinerary will be to unpack and have fun. See what’s available by searching through our vacation rentals in Seneca.