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Find 5 Star Hotels in South San Francisco, CA from $99

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Fairmont San Francisco
5 out of 5
950 Mason Street Atop Nob Hill, San Francisco, CA
The price is $287 per night from Feb 12 to Feb 13
4.5/5Wonderful! (1,436 reviews)

"Perfect in every way except that there was no microwave in the room. The room had one of the best views I have ever seen and the best hotel bathroom I have ever used."…"

Reviewed on Jan 4, 2021

Fairmont San Francisco
Four Seasons Hotel San Francisco at Embarcadero
5 out of 5
222 Sansome St, San Francisco, CA
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4.6/5Exceptional! (794 reviews)

"Very clean and new! Staff well trained and attentive. Good location....can walk to SOMA, Embarcadero, Union Square. The only downside, which isn't the fault of Four Seasons, is that so many businesses in the city are out of business and/or boarded up as it struggles to come back from the virus. Restaurants ..."…"

Reviewed on Oct 12, 2020

Four Seasons Hotel San Francisco at Embarcadero
Palace Hotel, a Luxury Collection Hotel, San Francisco
5 out of 5
2 New Montgomery St, San Francisco, CA
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4.4/5Wonderful! (1,144 reviews)

"I had the place almost all to myself right before the Palace's tragic COVID shutdown. It was a bittersweet experience. The staff was incredibly helpful."…"

Reviewed on Apr 1, 2020

Palace Hotel, a Luxury Collection Hotel, San Francisco
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The Ritz-Carlton, Half Moon Bay
5 out of 5
1 Miramontes Point Rd, Half Moon Bay, CA
Free CancellationReserve now, pay when you stay
The price is $825 per night from Jan 24 to Jan 25
4.5/5Wonderful! (513 reviews)

"We had a delightful stay! Our room overlooked the ocean and was what we expected. We were celebrating my daughter's 18th birthday. We arrived around 7 pm and we were surprised to be told the outside terrace closed at 7:30 pm. We were the last ones to put in an order for food at the bar and enjoyed ..."…"

Reviewed on Oct 16, 2020

The Ritz-Carlton, Half Moon Bay
Claremont Club & Spa - A Fairmont Hotel
5 out of 5
41 Tunnel Road, Berkeley, CA
Free Cancellation
The price is $251 per night from Jan 24 to Jan 25
4.5/5Wonderful! (991 reviews)

"The views were amazing! The sunset was beatiful! Check in was easy!"…"

Reviewed on Jan 19, 2021

Claremont Club & Spa - A Fairmont Hotel
The St. Regis San Francisco
5 out of 5
125 3rd St, San Francisco, CA
Free CancellationReserve now, pay when you stay
The price is $427 per night from Jan 30 to Jan 31
4.7/5Exceptional! (506 reviews)

"We loved staying here and felt very safe with the measures they took for the pandemic. Great location, city views. In room dining was delicious. Highly recommend."…"

Reviewed on Oct 26, 2020

The St. Regis San Francisco
Taj Campton Place
5 out of 5
340 Stockton St, San Francisco, CA
Free CancellationReserve now, pay when you stay
The price is $285 per night from Jan 29 to Jan 30
4.5/5Wonderful! (998 reviews)

"Staff was incredible amicable and helpful. Location is amazing. David at the front desk was incredibly efficient and professional."…"

Reviewed on Nov 23, 2020

Taj Campton Place
The Ritz-Carlton, San Francisco
5 out of 5
600 Stockton St, San Francisco, CA
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4.5/5Wonderful! (999 reviews)

"Jose and Leo were so accommodating and we felt taken care of the entire time. I can’t wait to return here!"…"

Reviewed on Feb 18, 2020

The Ritz-Carlton, San Francisco
Rosewood Sand Hill
5 out of 5
2825 Sand Hill Road, Menlo Park, CA
Free CancellationReserve now, pay when you stay
The price is $775 per night from Jan 24 to Jan 25
4.7/5Exceptional! (153 reviews)

"Staff was very attentive. Pool was spacious. Food options limited (might be due to Covid?)"…"

Reviewed on Oct 4, 2020

Rosewood Sand Hill
Four Seasons Hotel San Francisco
5 out of 5
757 Market St, San Francisco, CA
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4.6/5Wonderful! (735 reviews)

"Amazing"…"

Reviewed on Mar 2, 2020

Four Seasons Hotel San Francisco
Fairmont Heritage Place, Ghirardelli Square
5 out of 5
900 N Point Street, San Francisco, CA
The price is $695 per night from Jan 24 to Jan 25
4.7/5Exceptional! (279 reviews)

"The concierge service was great. They went above and beyond for the anniversary retreat we were on"…"

Reviewed on Jan 18, 2021

Fairmont Heritage Place, Ghirardelli Square
Mansion on Sutter
5 out of 5
1409 Sutter St, San Francisco, CA
The price is $216 per night from Jan 24 to Jan 25
4.7/5Exceptional! (76 reviews)

"The staff was so welcoming and the place is absolutely gorgeous! We got a complimentary bottle of wine upon arrival. The stay was simply sublime!!"…"

Reviewed on Jan 14, 2021

Mansion on Sutter
The Clement Hotel – All Inclusive
5 out of 5
711 El Camino Real, Palo Alto, CA
Free CancellationReserve now, pay when you stay
The price is $748 per night from Jan 24 to Jan 25
4.9/5Exceptional! (72 reviews)
Great place mediocre bed

"Overall this place is great, a little on the pricey side but if you utilized the all inclusive aspect of it, it makes you feel like it was worth it. Service is incredible and every employee there was very kind and helpful, the room was very nice with heated bathroom floors and tvs everywhere. My ..."…"

Reviewed on Oct 18, 2020

The Clement Hotel – All Inclusive
Four Seasons Hotel Silicon Valley at East Palo Alto
5 out of 5
2050 University Ave, Palo Alto, CA
Free CancellationReserve now, pay when you stay
The price is $600 per night from Feb 1 to Feb 2
4.7/5Exceptional! (483 reviews)

"the bathtub was broken"…"

Reviewed on Feb 22, 2020

Four Seasons Hotel Silicon Valley at East Palo Alto

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Ready for an incredible adventure? Add even more pleasure on your next trip to South San Francisco by treating yourself to the best of the best when it comes to accommodation. It's an ideal fusion. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made South San Francisco so popular in the last year. There's no reason to delay a getaway to South San Francisco any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in South San Francisco and get ready to be pampered like never before. Don't wait any longer!

Get a Great Deal on 5-Star Hotels in South San Francisco

You can expect high quality from your hotel. Spa treatments, delicious meals, and attentive guest service are all at your fingertips. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in South San Francisco offer great customer service, averaging 3.7 in our ranking system, giving you a lot to look forward to. What creature comforts do you want in your lodging? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? High thread-count sheets, piping hot coffees, and even spectacular views...these hotels are one-of-a-kind.

Can't wait to get outside? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in South San Francisco are waiting for you to rest up after a busy day. Ready to learn more? Then explore the 1,590 reviews various guests have left on Expedia and get to know these places.

Make Your Escape

The results are in, and South San Francisco 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Decide on one of Expedia's South San Francisco 5-star hotels today and soothe yourself in complete comfort tomorrow.

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