Beginning of main content

Best 5 stars Hotels in St. Louis

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

St. Louis Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Featured St. Louis 5 stars Hotels

See all 262 Hotels in St. Louis
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

999 North Second Street, St. Louis
5.0 out of 5.0
4.8 out of 5 (92 reviews)
Good hotel, location has some good/bad pointsThe experience staying at the Four Seasons in St. Louis was great overall. The staff were uniformly helpful and the room excellent. The attached casino is fine if you might want that facility - when I was there the restaurants attached to the casino were only open part-time with one exception, and ...
  May 5, 2017



St. Louis Five Star Hotel Information

Book private stadium tours and tickets to the symphony for a ritzy trip to St. Louis, Missouri.

  • Choose a fancy 5-star hotel in St. Louis that suits your high-end preferences
  • Earn perks for your loyalty through the Expedia+ program
  • Avoid spending a fortune when you book the cheapest hotel deals around

Treat yourself to the luxurious side of St. Louis.

Score the best seats in the house for a performance at the Opera Theatre of Saint Louis, and feel like a VIP when you receive a private tour of the Cardinals baseball stadium. During your sojourn, revel in a fancy charter cruise along the Mississippi River with unrivaled views of the Gateway Arch, and listen to the sweet sounds of the St. Louis Symphony at Powell Hall. Whether a luxe vacation means pampering yourself with a massage at one of the best spas in downtown or dining at an upscale restaurant on the riverfront, you’ll find it all right here in The Lou. Make a reservation at one of the 5-star hotels in St. Louis to continue your classy indulgences all vacation long.

Here at, we’re committed to providing you with the lavish getaway you desire at prices that won’t hurt your savings account. Take a look at our cheap deals on St. Louis 5-star hotels that pull out all the glamorous stops. You’ll find hotels with tranquility pools and steam rooms for the ultimate vacation experience. Sort through our selection of lodging today to discover everything from romantic places to luxury hotels in St. Louis that match all your high-class preferences.