Find 5 Star Hotels in St. Louis, MO from $156

Most hotels are fully refundable. Because flexibility matters.

Save 10% or more on over 100,000 hotels worldwide as a One Key member.

Search over 2.9 million properties and 550 airlines worldwide.

Compare St. Louis 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Louis.

Hyatt Regency St. Louis at The Arch

315 Chestnut St, St. Louis, MO

$156

$184 total

includes taxes & fees

Apr 25 - Apr 26

8.4/10 Very Good! (2,985 reviews)

Still don't see what you're looking for?

See all properties in St. Louis.

You can also use these popular filters to refine your search.

Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Treat your every whim on your upcoming break. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made St. Louis so popular in the last year. There's no reason to delay a getaway to St. Louis any longer. Furthermore, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. Reserve one of our 5-star hotels in St. Louis and indulge in the finer things in life for a while. What are you waiting for?

5-Star Hotels in St. Louis

Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Michelin-starred restaurants, exceptional customer care, and deeply relaxing spa offerings are all on offer. We have a huge number of hotels in the area, and all of them offer outstanding amenities. Additionally, the hotels in this area receive fantastic marks for guest services, so you know you'll want for nothing during your getaway. What creature comforts do you want in your lodging? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A mud wrap treatment that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here.

You won't sleep and order room service the entire time, though. We hear you. You'll find heaps to do in a large city like this one, like spending time trading stories with fellow visitors. Make friends with the locals -- they're sure to have advice on what kind of excitement you can find in town. Ready to learn more? Then explore the 3,653 reviews various guests have left on Expedia and get to know these places.

Your Getaway Starts Today

The results are in, and St. Louis 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in @region! Don't put off your dream vacation any longer. Decide on one of the 5-star hotels in St. Louis today and soothe yourself in complete comfort tomorrow.

Frequently asked questions

What are the best 5-star hotels in St. Louis?

Boasting first-rate amenities and guest services, our customers rate Four Seasons Hotel St Louis as among the best 5-star hotels in St. Louis. You’ll be immersed in a world of luxury from the moment you step foot into the lobby.

How much does it cost to stay in a 5-star hotel in St. Louis?

There are a range of pricing options for 5-star hotels in St. Louis on Expedia. How much you’ll pay will depend on your vacation dates, trip length and other factors. Compare all of the available accommodations for your chosen dates and make use of our pricing and other filters to find the perfect luxury stay.

Search for the lowest price per night from $156

What makes a hotel 5 stars in St. Louis?

In St. Louis, a hotel needs to offer a certain number of upscale features to be rated 5 stars. These may include on-site gyms, spas and saunas, gourmet restaurants, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their guest-centric service. You can expect things like concierge services, in-room massages and nightly turn-down services. Some may also offer additional touches like welcome gifts.

Are there any 5-star all-inclusive resorts in St. Louis?

Find a luxury escape that includes your room, meals, drinks and entertainment in St. Louis with the help of Expedia’s filter tool. Search for hotels with a 5-star rating and select the “All inclusive” filter. Make sure you check what’s included in the upfront price. That way, you’re ready to take advantage of all the premium perks when you arrive.

What are the top 5-star spa hotels in St. Louis?

For a rejuvenating stay in St. Louis, it’s hard to beat Four Seasons Hotel St Louis. Book in to this 5-star spa getaway and spend your days pampering yourself with its well-being programs and therapies.

Are there any 5-star vacation rentals in St. Louis?

You won’t find any 5-star vacation rentals in St. Louis on our site, but there are a few other top-rated properties worth checking out. Browse our vacation rentals in St. Louis to discover the perfect place for your stay.

Are there any 5-star hotels in downtown St. Louis?

Spend your break at Four Seasons Hotel St Louis and enjoy being close to the lively action of downtown St. Louis.