
Antofagasta Region Vacations & Trips from $248
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Your Antofagasta Region Vacation
Embark on your next epic adventure with an Antofagasta Region vacation package, and leave relaxed knowing all the details have been taken care of. Plus with the ability to customize your getaway, you know it'll be one to remember. With so much to do and see on a trip to Antofagasta Region, it can be tricky to know where to begin. Kick off your travels in San Pedro de Atacama at Piedra del Coyote Overlook and San Pedro Church — two popular attractions here. Another top city worthy of a spot on your itinerary is Antofagasta. Be sure not to miss Antofagasta Fish Market and Central Market. Expedia is your one-stop shop for planning your Antofagasta Region vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
The Latest Antofagasta Region Vacation Packages




Hotel Kimal
Reviewed on Sep 11, 2025

Hotel Cumbres San Pedro de Atacama
Reviewed on Sep 29, 2025
1. Plan your dream getaway to San Pedro de Atacama
San Pedro de Atacama in the Antofagasta Region of Chile offers a unique outdoor vacation experience. With its desert landscapes, adventure activities, and breathtaking natural scenery, it's a paradise for nature enthusiasts. The town is known for its charming cafes and delicious cheese, providing a delightful culinary experience. Excursions to explore volcanoes and stargazing tours are popular among visitors. Whether you're seeking thrilling outdoor adventures or simply want to immerse yourself in the stunning beauty of the desert, San Pedro de Atacama has something for everyone.
- Travelers tend to stay 3 days in San Pedro de Atacama
2. Discover Antofagasta with our vacation deals
Antofagasta, located in the Antofagasta Region of Chile, offers a diverse and captivating cultural vacation experience. With its stunning coastal views, this city is perfect for relaxation and enjoying the sunny weather. Visitors can explore the local shops and indulge in delicious seafood dishes. The city also boasts historical monuments and a bustling port, offering a glimpse into its rich history and maritime heritage. Nature enthusiasts can enjoy birdwatching along the coast, while business travelers will find a thriving commercial atmosphere. Finally, don't miss the breathtaking sunsets that paint the sky in vibrant colors each evening.
- The peak season is from January to March
- The off-peak season is from October to December
- Travelers tend to stay 3 days in Antofagasta
3. Escape to Calama with a vacation package
Calama, located in the Antofagasta Region of Chile, offers a unique atmosphere and experience for a family vacation. With its diverse geographic affinities, including deserts, ruins, and secluded areas, there is something for everyone to enjoy. Families can explore the stunning desert landscapes, visit ancient ruins, and indulge in delicious local cheese. Camping and theme park activities are also popular options for outdoor enthusiasts. For those seeking entertainment, Calama offers opera performances and a casino. Additionally, the city is home to charming churches that provide a glimpse into its rich history and culture.
- The peak season is from January to March
- The off-peak season is from April to June
- Travelers tend to stay 2 days in Calama
4. Create memories in Historical District with a vacation package
The Historical District in Antofagasta, Chile, offers a unique atmosphere for a city vacation. With its stunning coastal location, visitors can enjoy activities such as walking along the beach and exploring the historical monuments. The district also offers opportunities for theater performances, exciting excursions, and shopping. Whether you're interested in business or leisure, the area has plenty to offer. Additionally, the friendly people and diverse dining options add to the overall experience. Don't forget to visit the museums to learn more about the rich history of the region. The Historical District truly has something for everyone.
6. Book your ideal Mejillones with a vacation package
Mejillones, located in the Antofagasta Region of Chile, offers a vibrant atmosphere for beach vacations. With its stunning natural parks and beautiful beaches, it is a paradise for nature lovers. The town also boasts interesting museums that provide insights into the local culture and history. Visitors can engage in a variety of activities, including destination tours and sightseeing. Whether you want to relax on the beach or explore the surrounding natural beauty, Mejillones has something for everyone. Don't miss the opportunity to immerse yourself in the local atmosphere and enjoy a memorable vacation in this charming coastal town.
- The peak season is from January to March
- The off-peak season is from April to June
- Travelers tend to stay 4 days in Mejillones
5. Explore Toconao with a vacation package
Toconao, located in the Antofagasta Region of Chile, offers a captivating atmosphere for outdoor enthusiasts. With its stunning natural parks and picturesque landscapes, it is the perfect destination for a nature-focused vacation. Immerse yourself in the beauty of the region as you explore its geographic affinities. Whether you choose to hike through rugged canyons, visit the nearby San Pedro de Atacama for stargazing, or simply indulge in the tranquility of the area, Toconao guarantees an unforgettable experience for those seeking an outdoor adventure in the heart of Chile.
- The peak season is from July to September
- The off-peak season is from October to December
Best months to visit Antofagasta Region
Looking for the best time to visit Antofagasta Region? Our table will help you. Antofagasta Region boasts a year-round average temperature of 56.7°F, reaching a peak of 63.5°F in January, its warmest month, and dropping to an average low of 48.0°F in June, July, the coolest month. The annual rainfall averages 9.0mm, with February experiencing the heaviest showers, while November is the driest month.
Month![]() | Temperature (Fahrenheit)![]() | Rainfall![]() | Cloud coverage![]() |
January | 63.5 | No Rain (Dry) | Sunny |
February | 62.6 | No Rain (Dry) | Sunny |
March | 61.7 | No Rain (Dry) | Sunny |
April | 57.4 | No Rain (Dry) | Sunny |
May | 51.6 | No Rain (Dry) | Sunny |
June | 48.0 | No Rain (Dry) | Sunny |
July | 48.0 | No Rain (Dry) | Sunny |
August | 50.5 | No Rain (Dry) | Sunny |
September | 55.0 | No Rain (Dry) | Sunny |
October | 58.5 | No Rain (Dry) | Sunny |
November | 61.2 | No Rain (Dry) | Sunny |
December | 62.8 | No Rain (Dry) | Sunny |
How to save money on a vacation to Antofagasta Region
- Combine your flights with hotels or car rentals to save money, especially in Antofagasta Region.
- Take advantage of Expedia's OneKey program to collect points and save money on your travel package to Antofagasta Region.
- Utilize the helpful search filters on Expedia to find the perfect accommodation within your price range.
- Consider traveling during the off-peak season (December-February) for potentially lower prices and fewer crowds.
- Use the search filter for price limits on Expedia to find a package deal that suits your budget.
- Discover the best vacation experience for you by using the travel experience filter on Expedia, whether it's a family, romantic, or adventurous getaway.
Antofagasta Region Essential Information
Language | Spanish |
---|---|
Currency | Chilean pesos |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Cerro Moreno Intl. Airport (ANF) |
Population | 309,800 |
Top Sights | Valley of the Moon, Arco Iris Valley and Puritama Hot Springs |
Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama
Reviewed on Aug 23, 2025

Noi Casa Atacama
Reviewed on Sep 1, 2025

Hotel La Casa de Don Tomas
Reviewed on Jun 10, 2025
Frequently asked questions
Discover the most popular places to visit in Antofagasta Region

Plaza de San Pedro de Atacama
You can find out about the history of San Pedro de Atacama when you stop by Plaza de San Pedro de Atacama. You can seek out the local tours in this quaint area.

Valley of the Moon
Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.

San Pedro Church
San Pedro Church is just one of the places to see in San Pedro de Atacama, so why not enjoy the other things to explore during your travels? You can seek out the local tours in this quaint area.
What to do in Antofagasta Region

Stargazing Tour in San Pedro de Atacama
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