Find all hotels by Independent in Cairo, IL from $61

Most hotels are fully refundable. Because flexibility matters.

Save 10% or more on over 100,000 hotels worldwide as a One Key member.

Search over 2.9 million properties and 550 airlines worldwide.

Compare rooms and suites by Independent in Cairo with rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
10.0 out of 10, Exceptional, (138)
"Everything here was above and beyond nicer than home. Such a beautiful property and wonderful host. We loved it here! We enjoyed making breakfast in the kitchen which had everything we could need and Kiwi our pup loved the yard. Seriously would give this place 6 stars if I could. The house is beautiful and well cared for and full of cool historical details & decors. Thanks again for having us!"
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Basic Double Room | Free WiFi
La Center Motel
2.0 star property
6.0 out of 10, (3)
"Very good. It’s an older motel but the new owners are repairing and upgrading units. Staff was willing to assist in any way, eager to please. Highly recommend."
The price is $61
$71 total
includes taxes & fees
May 24 - May 25
La Center Motel
Exterior
Regency Inn
2.0 star property
Regency Inn
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Exterior
Charming cottage overlooking Lake Acre
10.0 out of 10, Exceptional, (84)
"What a cute property that is nicely furnished and very comfortable. Suzie was a great host and we’d definitely book this place again."
The price is $150
$256 total
includes taxes & fees
May 30 - May 31
Charming cottage overlooking Lake Acre
Interior
Cozy cabins on beautiful Horseshoe Lake
9.8 out of 10, Exceptional, (18)
"We were looking for a place to view the 2024 solar eclipse and we found this cabin, which was in the path of totality! We were so excited to be able to view the eclipse from the property, which meant that we didn't have to deal with traffic getting home or to other lodging. Sherry was a great host. The cabin was quiet and clean. and just perfect for a two-night stay. "
The price is $115
$135 total
includes taxes & fees
May 23 - May 24
Cozy cabins on beautiful Horseshoe Lake
Beautiful Cabin Retreat
8.2 out of 10, Very Good, (39)
"Host had the cabin very clean. New leather couch & recliner. Mattress was extremely comfortable. Washer & Dryer were excellent. Another Rental house near, long-term renters were very quiet. Internet not very good in the Illinois woods. Closed cabin has a musty smell from humidity in the woods. Host had an automatic air freshener going to help with air quality."
The price is $120
$192 total
includes taxes & fees
May 23 - May 24
Beautiful Cabin Retreat
Dining
The Rested Duck Mallard Room
8.8 out of 10, Excellent, (14)
"Lovely, unexpected gem! I would love to come back again!"
The price is $115
$143 total
includes taxes & fees
May 24 - May 25
The Rested Duck Mallard Room
TV, fireplace
Upscale & Quiet Paducah Retreat on 15 Acres!
9.8 out of 10, Exceptional, (20)
"Nicely decorated, roomy, prompt attention to a minor issue. Tucked away and private."
Upscale & Quiet Paducah Retreat on 15 Acres!
Property grounds
Charming Home just minutes from Interstate and Mall
10.0 out of 10, Exceptional, (10)
"Me and a couple friends were looking for a place to stay in the area so we could do some outdoors recreation. This house was perfect and had everything we needed to be comfortable when we weren't out in the woods."
The price is $110
$187 total
includes taxes & fees
Jun 3 - Jun 4
Charming Home just minutes from Interstate and Mall
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston
2.0 star property
6.8 out of 10, (93)
"Simple but clean. Bathroom door would not close due to water damage on bottom. This was only issue. Comfortable sleeping "
The price is $69
$77 total
includes taxes & fees
May 23 - May 24
Eagle Inn Charleston
Don't see what you're looking for?
See all available properties in Cairo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Independent Cairo Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Cairo, Illinois. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Cairo hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Cairo Independent locations may even offer extra little benefits and discounts for frequent travelers.

Recent reviews of Cairo hotels
Expedia verified reviews

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre

5/5 Excellent
Cute Cabin in the Woods
"What a cute property that is nicely furnished and very comfortable. Suzie was a great host and we’d definitely book this place again."
A verified traveler stayed at Charming cottage overlooking Lake Acre
Posted 7 days ago
Charming cottage overlooking Lake Acre