Cairo Vacations from US$ 728
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
You can save when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Cairo Vacation
The exciting city of Cairo is calling. Discover its hot spots and hidden treasures with a Cairo vacation package that's custom made for you. Need some ideas on what to do or see first during your trip to Cairo? Head straight for famous attractions like Fort Defiance State Park. No matter your travel plans or the size of your budget, putting together a tailored Cairo vacation is simple with Expedia.
The Latest Cairo Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Holiday Inn Paducah Riverfront by IHG
Price was US$ 854, price is now US$ 784 per person
US$ 784
per person
Nov 14 - Nov 17
found 9 hours ago
Roundtrip flight included
Los Angeles (LAX) to Paducah (PAH)
9/10 Wonderful! (896 reviews)
My room had a balcony, giving a nice view of the river. The room appeared clean and well appointed. The breakfast as nice, but overpriced.
Reviewed on 24 Sep, 2025
Find the Best Cairo Vacation Packages
Cairo Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Cape Girardeau Municipal Airport (CGI) |
Population | 2,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 85ºF |
Cairo Hotel Deals
Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Fully refundableReserve now, pay when you stay
6.4/10 (270 reviews)
"Break fast was excellent"
Reviewed on 28 Sep, 2025
Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Fully refundableReserve now, pay when you stay
6.6/10 (592 reviews)
"Thank you!!!"
Reviewed on 26 Sep, 2025
Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8/10 Exceptional! (18 reviews)
"cute A frame in a secluded spot. Couldn’t ask for a more relaxing situation."
Reviewed on 31 Aug, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Cairo
Fort Defiance State Park
4/5(14 reviews)
You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
Other vacations you might like
- Nearby Cities
- Destinations similar to Cairo
- Vacations from
- Best vacation destinations by month
- Expedia's Latest Trends
- Vacations from Atlanta
- Vacations from Austin
- Vacations from Boston
- Vacations from Chicago
- Vacations from Dallas
- Vacations from Houston
- Vacations from Las Vegas
- Vacations from Los Angeles
- Vacations from Miami
- Vacations from New York
- Vacations from Orlando
- Vacations from Philadelphia
- Vacations from Phoenix
- Vacations from Pittsburgh
- Vacations from Seattle
- Vacations from Washington
- January Vacations and Deals
- February Vacations and Deals
- March Vacations and Deals
- April Vacations and Deals
- May Vacations and Deals
- June Vacations and Deals
- July Vacations and Deals
- August Vacations and Deals
- September Vacations and Deals
- October Vacations and Deals
- November Vacations and Deals
- December Vacations and Deals
Expedia's Latest Trends
Hotels
- Hotel Rooms in Galena
- Morton Golf Hotels
- Hotel Rooms in O'Fallon
- Hotel Rooms in Bloomington
- Hotel Rooms in Decatur
- Hotel Rooms in Urbana
- Hotel Rooms in Champaign
- Hotel Rooms in Peoria
- Hotel Rooms in Galesburg
- Hotel Rooms in Springfield
- Hotel Rooms in Mount Vernon
- Hotel Rooms in Aurora
- Hotel Rooms in Tinley Park
- Hotel Rooms in Elgin
- Hotel Rooms in Quincy
- Hotel Rooms in Rockford
- Hotel Rooms in Carbondale
- Hotel Rooms in Moline
- Hotel Rooms in Joliet
- Hotel Rooms in Effingham
- Hotel Rooms in Marion
Cars
General
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.