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Your Cairo Vacation
The exciting city of Cairo is calling. Discover its hot spots and hidden treasures with a Cairo vacation package that's custom made for you. Need some ideas on what to do or see first during your trip to Cairo? Head straight for famous attractions like Fort Defiance State Park. No matter your travel plans or the size of your budget, putting together a tailored Cairo vacation is simple with Expedia.
The Latest Cairo vacation packages
Price found within the past 48 hours. Click for updated prices.

Comfort Suites Hopkinsville near Fort Campbell
Price was $448, price is now $390 per person
$390
per person
Oct 10 - Oct 13
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to Paducah (PAH)
9/10 Wonderful! (506 reviews)
The Comfort Inn was awesome, clean, and everyone was friendly, considering I stayed in a Hilton in Clarksville, TN, and it wasn't very good. Comfort Inn beat them by a mile. Thanks for the awesome service and clean room.
Reviewed on Jul 29, 2025


The Respite Bed and Breakfast
Price was $874, price is now $745 per person
$745
per person
Nov 4 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Paducah (PAH)
9.8/10 Exceptional! (242 reviews)
Could not control air in our room. We stayed during the first week of August. It was hot and wish we had a thermostat in room to turn air conditioning temperature down.
Reviewed on Aug 9, 2025

La Quinta Inn & Suites by Wyndham Paducah
Price was $767, price is now $668 per person
$668
per person
Nov 4 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Paducah (PAH)
8.8/10 Excellent! (1,008 reviews)
The pool area was a mess, outdoor patio cushions were out by the railroad tracks. Stained carpet in our room.
Reviewed on Aug 23, 2025

Discover the most popular places to visit in Cairo
Fort Defiance State Park
You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
Cairo Hotel Deals

Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $77 total per night from Sep 11 to Sep 12
$77 total
Sep 11 - Sep 12
Total with taxes and fees
6.4/10 (264 reviews)
"The checkin was fast and easy. The room is big and comfortable."
Reviewed on Aug 6, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $64 total per night from Sep 8 to Sep 9
$64 total
Sep 8 - Sep 9
Total with taxes and fees
6.6/10 (584 reviews)
Big rooms
"We stay here a lot. It is conveniently located. We like the nice big rooms."
Reviewed on Aug 21, 2025

Peaceful secluded cabin located near Horseshoe Lake
Miller City
$175 nightly
The price is $185 total per night from Aug 24 to Aug 25
$185 total
Aug 24 - Aug 25
Total with taxes and fees
9.8/10 Exceptional! (17 reviews)
"Out of the way location was just the solitude I needed! Thank you for sharing your home with us."
Reviewed on Aug 15, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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- Hotels near Fort Defiance State Park
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- Flights from Cairo Regional
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.