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Your Cairo Vacation
The exciting city of Cairo is calling. Discover its hot spots and hidden treasures with a Cairo vacation package that's custom made for you. Need some ideas on what to do or see first during your trip to Cairo? Head straight for famous attractions like Fort Defiance State Park. No matter your travel plans or the size of your budget, putting together a tailored Cairo vacation is simple with Expedia.
The Latest Cairo vacation packages
Price found within the past 48 hours. Click for updated prices.

Super 8 by Wyndham Metropolis
per person
Sep 8 - Sep 12
found 19 hours ago
Roundtrip flight included
Charlotte (CLT) to Paducah (PAH)
7/10 Good! (481 reviews)
For the price this is a great choice. It’s outdated but was clean, pool was nice, and came with r breakfast. For the value I would stay again.
Reviewed on Jul 14, 2025

La Quinta Inn & Suites by Wyndham Paducah
per person
Sep 8 - Sep 12
found 19 hours ago
Roundtrip flight included
Charlotte (CLT) to Paducah (PAH)
8.8/10 Excellent! (1,004 reviews)
Consistently providing good services , very clean rooms . Just great value for the money I count on and will return
Reviewed on Jul 31, 2025

Days Inn by Wyndham Kuttawa/Eddyville
per person
Sep 8 - Sep 12
found 19 hours ago
Roundtrip flight included
Charlotte (CLT) to Paducah (PAH)
8/10 Very Good! (519 reviews)
Overall, it was decent for the money. There were a few spot of mold in the bathroom. The ice maker was not working. On the other hand, someone came right out with new towels for the pool after the others got wet from a shower.
Reviewed on Jul 16, 2025


Discover the most popular places to visit in Cairo
Fort Defiance State Park
4/5(14 reviews)
You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
Cairo Hotel Deals

Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $81 total per night from Aug 10 to Aug 11
$81 total
Aug 10 - Aug 11
Total includes taxes and fees
6.4/10 (263 reviews)
"It was ok. We were just passing by"
Reviewed on Jun 10, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Fully refundableReserve now, pay when you stay
$60 nightly
The price is $67 total per night from Aug 3 to Aug 4
$67 total
Aug 3 - Aug 4
Total includes taxes and fees
6.6/10 (575 reviews)
"Everything worked like it should and bed was comfortable"
Reviewed on Jul 22, 2025

Quality Inn Charleston - Sikeston
102 Drake St, I-57 Exit 10, Charleston, MO
Fully refundableReserve now, pay when you stay
$68 nightly
The price is $75 total per night from Aug 12 to Aug 13
$75 total
Aug 12 - Aug 13
Total includes taxes and fees
6.8/10 (396 reviews)
"I consistently choose to stay there due to positive past encounters."
Reviewed on Jul 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.