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Your Cairo Vacation
The exciting city of Cairo is calling. Discover its hot spots and hidden treasures with a Cairo vacation package that's custom made for you. Need some ideas on what to do or see first during your trip to Cairo? Head straight for famous attractions like Fort Defiance State Park. No matter your travel plans or the size of your budget, putting together a tailored Cairo vacation is simple with Expedia.
The Latest Cairo vacation packages
Price found within the past 48 hours. Click for updated prices.




The Respite Bed and Breakfast
per person
Nov 4 - Nov 9
found 4 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Paducah (PAH)
9.8/10 Exceptional! (236 reviews)
Could not control air in our room. We stayed during the first week of August. It was hot and wish we had a thermostat in room to turn air conditioning temperature down.
Reviewed on Aug 9, 2025

The Lakehouse Inn at Sledd Creek
per person
Nov 4 - Nov 9
found 4 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Paducah (PAH)
9.8/10 Exceptional! (118 reviews)
The décor at Lakehouse Inn is very charming. The room was spacious and very clean. The kitchenette in the room was small but very nicely stocked with anything we needed. The pool area is beautiful, and we enjoyed the DJ very much. The staff at the Inn was wonderful. Nevaeh was friendly and efficient, and made sure we had everything we needed. We will definitely stay there again.
Reviewed on Jul 11, 2025
Discover the most popular places to visit in Cairo
Fort Defiance State Park
You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.
Cairo Hotel Deals

Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Fully refundableReserve now, pay when you stay
$69 nightly
The price is $77 total per night from Sep 8 to Sep 9
$77 total
Sep 8 - Sep 9
Total includes taxes and fees
6.4/10 (264 reviews)
"The checkin was fast and easy. The room is big and comfortable."
Reviewed on Aug 6, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $65 total per night from Sep 8 to Sep 9
$65 total
Sep 8 - Sep 9
Total includes taxes and fees
6.6/10 (580 reviews)
"Located very close to the expanse of corn fields, quiet, clean rooms, everything is neat, the bathroom is also very clean. Friendly receptionist."
Reviewed on Aug 1, 2025

Peaceful secluded cabin located near Horseshoe Lake
Miller City
$175 nightly
The price is $185 total per night from Aug 20 to Aug 21
$185 total
Aug 20 - Aug 21
Total includes taxes and fees
9.8/10 Exceptional! (15 reviews)
"This place is beautiful and VERY CLEAN. Super secluded, but with a dollar store close enough if you forget to bring anything. Although if you are bringing a dog that might take the occasional toilet sip in unfamiliar places, make sure to enter the cabin ahead of them and close the toilet lid or bathroom ..."
Reviewed on Aug 14, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.