I stayed at Hotel Golden Horn for 1 night as part of an Intrepid tour and also extended my stay after the tour was over.
I found this hotel to be in an excellent and safe neighbourhood and I was a solo female traveler walking every where. It is close to the Orient express station, a police station, many shops & restaurants, Topkapi Palace and Sultanamet. It is walking distance to all of the main sites in other words.
The rooms were small, but comfortable and clean.
The views from the upstairs "happy hour" lounge was a pleasant surprise! Do not hesitate to visit the 5th floor just to take some beautiful shots of the Bosphorous and Istanbul skyline. The staff was excellent, courteous and professional. The breakfast was plentiful and delicious.
I would not hesitate to stay here again and would recommend it to any traveler looking to explore the beautiful city of Istanbul.