Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Central San Diego Adventure Hotels

See all 196 Hotels in Central San Diego
Country Inn & Suites by Carlson-San Diego North

Country Inn & Suites by Carlson-San Diego North

5975 Lusk Blvd, San Diego
3.5 out of 5.0
4.3 out of 5 (1,968 reviews)
Nice quite location and close to UCSD& restaurentsHotel is very clean and staff is very friendly and also the location is very convenient, not but not least we enjoyed fresh breakfast
  Nov 30, 2017

$107

$107
HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa

10044 Pacific Mesa Blvd, San Diego
3.5 out of 5.0
4.5 out of 5 (1,222 reviews)
Quiet, Clean, Comfortable Great hotel for a business stay. Quiet, clean and comfortable.
  Dec 13, 2017

$132

$132
Courtyard by Marriott San Diego Sorrento Valley

Courtyard by Marriott San Diego Sorrento Valley

9650 Scranton Rd, San Diego
3.0 out of 5.0
4.2 out of 5 (589 reviews)
Convenient for a night stay. Comfortable placeIt is a nice quiet evening. Close to San Diego and shopping.
  Dec 15, 2017

$87

$87
Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel

9310 Kearny Mesa Rd, San Diego
3.0 out of 5.0
3.8 out of 5 (918 reviews)
Great hotel at a great price!Front desk staff was very friendly and accomodating.
  Nov 28, 2017

$100

$100
Ramada San Diego North Hotel and Conference Center

Ramada San Diego North Hotel and Conference Center

5550 Kearny Mesa Rd, San Diego
3.0 out of 5.0
3.8 out of 5 (3,435 reviews)
Old building ,but clean and quite.Good price, room blow my expectations, very ,very clean .I felt my car was safe outside I, only wish they had a USB port.
  Dec 13, 2017

$78

$78
Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central

8651 Spectrum Center Blvd, San Diego
3.5 out of 5.0
4.3 out of 5 (780 reviews)
Fantastic!!!!This hotel was GREAT!!! The rooms are VERY clean. I always leave hotels talking crap about something I didn't like BUT this hotel exceed my expectation. Quiet and cozy. Definitely going there again!! Thank you for making my stay more enjoyable :)
  Oct 30, 2017

$107

$107
Four Points by Sheraton San Diego

Four Points by Sheraton San Diego

8110 Aero Dr, San Diego
3.5 out of 5.0
3.6 out of 5 (1,192 reviews)
Clean good location great price Everything great comfortable bed extremely clean good location good for family or business trip
  Dec 18, 2017

$63

$63
Residence Inn San Diego Sorrento Mesa/Sorrento Valley

Residence Inn San Diego Sorrento Mesa/Sorrento Valley

5995 Pacific Mesa Ct, San Diego
3.5 out of 5.0
4.5 out of 5 (197 reviews)
Perfect hotel to stay atThe rooms are spacious and having a mini kitchen is so useful. And their breakfast is surprisingly delicious and complimentary ..yes complimentary! I mean cmon waffles w Nutella! Yum! Staff is very friendly as well.
  Dec 4, 2017

$119

$119
California Suites Hotel

California Suites Hotel

5415 Clairemont Mesa Blvd, San Diego
2.5 out of 5.0
3.3 out of 5 (1,914 reviews)
Wonderful StaffThe hotel staff were so polite. They provided excellent customer service and made sure I received everything I needed for a comfortable stay.
  Dec 11, 2017

$64

$64
Staybridge Suites Sorrento Mesa

Staybridge Suites Sorrento Mesa

6639 Mira Mesa Blvd, San Diego
3.0 out of 5.0
4.4 out of 5 (327 reviews)
StaffGood hotel except for staff....it took the front desk guy 30 mins and 2 phone calls to bring me an extra key, after the other one won't work. That's just rude But other than that is a beautiful hotel,great location
  Dec 16, 2017

$85

$85
Quality Inn San Diego Miramar

Quality Inn San Diego Miramar

9350 Kearny Mesa Rd, San Diego
3.0 out of 5.0
3.5 out of 5 (464 reviews)
Not bad for price next to alot of breweries in industrial area
  Aug 30, 2017

$68

$68
Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa

5434 Kearny Mesa Rd, San Diego
3.0 out of 5.0
4.5 out of 5 (559 reviews)
comfortable!We experienced the most comfortable bed that we have ever had in a hotel. Room was quiet from noises from other rooms, did hear a little bit of noise from the parking lot.
  Oct 20, 2017

$112

$112
Residence Inn By Marriott San Diego Central

Residence Inn By Marriott San Diego Central

5400 Kearny Mesa Rd, San Diego
3.0 out of 5.0
4.5 out of 5 (512 reviews)
Friendly staff My boyrfriend and I stayed overnight for my birthday. The staff was so kind they even left a birthday gift at our door! The actual hotel may be a little dates, but the hotel staff's professionalism and kindness make up for it. Would definitely stay again!
  Nov 14, 2017

$119

$119
Map

Recently booked Adventure Hotels in Central San Diego

HYATT house San Diego/Sorrento Mesa
3.5 out of 5.0
Last booking: 25 minutes ago
Pleasant Inn
3.0 out of 5.0
Last booking: 42 minutes ago
Extended Stay America San Diego - Sorrento Mesa
3.0 out of 5.0
Last booking: 1 hour ago
California Suites Hotel
2.5 out of 5.0
Last booking: 1 hour ago
Residence Inn San Diego Sorrento Mesa/Sorrento Valley
3.5 out of 5.0
Last booking: 3 hours ago
Residence Inn By Marriott San Diego Central
3.0 out of 5.0
Last booking: 8 hours ago
Hampton Inn San Diego-Kearny Mesa
3.0 out of 5.0
Last booking: 9 hours ago
Best Western San Diego/Miramar Hotel
3.0 out of 5.0
Last booking: 10 hours ago
Extended Stay America San Diego - Mission Valley - Stadium
2.5 out of 5.0
Last booking: 13 hours ago

Pocket Guide: Adventure Hotels in Central San Diego

Search for hotels in Central San Diego on Expedia. You can easily find your hotels in Central San Diego using one of the methods below:

  • View our selection of featured hotels in Central San Diego
  • Use the map to find hotels in the Central San Diego neighborhood you prefer
  • Use the filters to see hotels in a specific area of Central San Diego, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Central San Diego
  • Enter your travel dates to view the best deals on hotels in Central San Diego - while they last