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Featured Central San Diego Luxury Hotels

See all 189 Hotels in Central San Diego
Ramada San Diego North Hotel and Conference Center

Ramada San Diego North Hotel and Conference Center

5550 Kearny Mesa Rd, San Diego
3.0 out of 5.0
3.7 out of 5 (3,511 reviews)
Nice, relaxing and freeway closeNeeded to get away for a day and it did the trick. Nothing fancy, but a decent hotel, worth the price.
 COB May 12, 2014

$72

$72
Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel

9310 Kearny Mesa Rd, San Diego
2.5 out of 5.0
3.8 out of 5 (906 reviews)
Good locationFor my needs the hotel was perfect nothing fancy but clean and comfortable, close to the freeway which made it easy access to wherever I wanted to go.
 daisy May 16, 2016

$100

$100
California Suites Hotel

California Suites Hotel

5415 Clairemont Mesa Blvd, San Diego
2.0 out of 5.0
3.5 out of 5 (3,465 reviews)
Good location, great on a budgetGrounds were very pretty, the pool was fun and loved the coy pond. The rooms have seen a better day but they did the job. The breakfast left something to be desired but really, not that big of a deal. Very affordable, staff was super nice as well. If you don't have the money for fancy on the beach, ...
 The bean Sep 12, 2014

$64

$64
Quality Inn San Diego Miramar

Quality Inn San Diego Miramar

9350 Kearny Mesa Rd, San Diego
2.5 out of 5.0
3.5 out of 5 (457 reviews)
Value hotel, near Miramar MCASNothing fancy, but filled our needs. Wanted to stay close to the base to see our son, very convenient to the gate. Staff was very friendly, and able to answer questions about nearby amenities. No elevator, but that wasn't an issue for us. Room was large, and very clean. Surprised to see such a good ...
 Elizabeth Nov 17, 2015

$80

$80
Four Points by Sheraton San Diego

Four Points by Sheraton San Diego

8110 Aero Dr, San Diego
3.0 out of 5.0
3.6 out of 5 (1,167 reviews)
Nice hotel in San DiegoI'm impressed by how big and new the hotel is in this expensive land of San Diego. The room is big and comfortable, not fancy but responds to the travelers needs. The medium size refrigerator allows me to stock some juice, beer and water to reduce my thirst after a long day enjoying sightseeing what ...
 Frank Sep 18, 2016

$76

$76
Country Inn & Suites by Carlson-San Diego North

Country Inn & Suites by Carlson-San Diego North

5975 Lusk Blvd, San Diego
3.0 out of 5.0
4.3 out of 5 (2,333 reviews)
Average...but Better Than Motel...Area SafeFirst impressions were hotel was dated, carpet and decor old and worn out. Location safe but nothing special. Hot breakfast much better than continental but not great...but nice it's included. Low price, free parking, safe location, and free breakfast is why I chose hotel. If you don't plan on hanging ...
  Oct 4, 2017

$107

$107
Extended Stay America San Diego - Sorrento Mesa

Extended Stay America San Diego - Sorrento Mesa

9880 Pacific Heights Blvd, San Diego
2.5 out of 5.0
3.1 out of 5 (525 reviews)
Affordable, comfortable hotel close to UCSD.My family of four, including a prospective college student, were visiting UC San Diego. There are many, very expensive luxury hotels near the campus, but we needed instead a simple, affordable, place to stay, and this fit the bill very well, being only a 10 minute drive from UCSD. The room was comfortable ...
 Scott  Apr 13, 2017

$94

$94
Motel 6 San Diego North

Motel 6 San Diego North

5592 Clairemont Mesa Blvd, San Diego
2.0 out of 5.0
3.2 out of 5 (259 reviews)
Pleasantly surprisedI always avoided Motel 6. But this one was very nice. The staff was helpful and the room was clean. No, it was not luxury, but for a clean place to sleep with good bus access, this was fine. I'd stay here again.
 Steven Jul 27, 2014

$66

$66
Residence Inn By Marriott San Diego Central

Residence Inn By Marriott San Diego Central

5400 Kearny Mesa Rd, San Diego
3.0 out of 5.0
4.5 out of 5 (510 reviews)
Friendly staff My boyrfriend and I stayed overnight for my birthday. The staff was so kind they even left a birthday gift at our door! The actual hotel may be a little dates, but the hotel staff's professionalism and kindness make up for it. Would definitely stay again!
  Nov 14, 2017

$119

$119
Holiday Inn San Diego North Miramar

Holiday Inn San Diego North Miramar

9335 Kearny Mesa Rd, San Diego
3.0 out of 5.0
4.2 out of 5 (405 reviews)
Very nice employees. We only stayed one night. But, it was clean and I would recommend this hotel to anyone vacationing. Next visit to San Diego I’m definitely going to stay here.
  Oct 9, 2017

$114

$114
Map

Recently booked Luxury Hotels in Central San Diego

California Suites Hotel
2.0 out of 5.0
Last booking: 2 hours ago
Ramada San Diego North Hotel and Conference Center
3.0 out of 5.0
Last booking: 3 hours ago
Four Points by Sheraton San Diego
3.0 out of 5.0
Last booking: 4 hours ago
Hampton Inn San Diego-Kearny Mesa
2.5 out of 5.0
Last booking: 5 hours ago
Extended Stay America San Diego - Sorrento Mesa
2.5 out of 5.0
Last booking: 8 hours ago
Best Western San Diego/Miramar Hotel
2.5 out of 5.0
Last booking: 9 hours ago
Holiday Inn San Diego North Miramar
3.0 out of 5.0
Last booking: 9 hours ago
Courtyard by Marriott San Diego Sorrento Valley
3.0 out of 5.0
Last booking: 16 hours ago
Country Inn & Suites by Carlson-San Diego North
3.0 out of 5.0
Last booking: 16 hours ago

A few days away keeps your worries at bay, so plan a vacation in Central San Diego and get ready to relax. Fascinating sites, delicious eats, and some of the world’s most stunning photo opportunities: these are just some of the reasons to take a vacation to Central San Diego. You'll treat yourself to the city's best food, marvel at the most noteworthy points of interest , and grab tickets to the most popular performances. Where else would you stay but a luxury accommodation? Anything less than the best is for the birds, so reserve your upscale hotel in Central San Diego on Expedia.com today, and your relaxing getaway is off to a great start.

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Luxury Hotels in Central San Diego

When you’ve got your heart set on an elegant getaway in Central San Diego, Expedia.com is here to save the day. Browse the bounty of ratings and reviews on incredible hotels and then book your ideal room in minutes. Luxury accommodations offer amenities like spacious suites and VIP services. Some of the city's 5-star accommodations even feature upscale penthouses, while others offer exquisite in-room dining. Book your luxury experience in Central San Diego now, and before you know it you'll be feeling blissful in paradise!