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Featured Central San Diego Resorts & Hotels with Spas

See all 249 Hotels in Central San Diego
California Suites Hotel

California Suites Hotel

5415 Clairemont Mesa Blvd, San Diego
2.5 out of 5.0
3.3 out of 5 (1,937 reviews)
Great spot close to freewayHotel had easy access to freeway, had some friendly permanent residents and rooms were clean. Unfortunately beds were double rather than queens but apart from that we were happy with the room. Aladdin restaurant across the road had some of the best salads I have ever eaten which is a nice change ...
 Daryl Oct 2, 2016

$64

$64
Ramada San Diego North Hotel and Conference Center

Ramada San Diego North Hotel and Conference Center

5550 Kearny Mesa Rd, San Diego
4.0 out of 5.0
3.8 out of 5 (3,528 reviews)
Nice hotel, close to freeway and attractionshelpful staff room was clean and looked like it had been recently renovated. Wonderful shower! nice big pool area and spa. grounds were very well manicured enjoyed our staya nd will definitely go back
 cathy Sep 8, 2015

$90

$90
Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central

8651 Spectrum Center Blvd, San Diego
3.5 out of 5.0
4.3 out of 5 (802 reviews)
Very nice hotel with a great location!Room was very clean and updated! The bed and pillows were very comfortable! Starbucks in the lobby, and a very nice pool and spa! They even have an outdoor, two sided fireplace with nice cushioned chairs to relax in! We will definitely stay here on our next vacation to San Diego!
 Sarah Nov 28, 2015

$119

$119
Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA

5975 Lusk Blvd, San Diego
3.5 out of 5.0
4.3 out of 5 (1,994 reviews)
Nice hotelClean hotel, friendly staff, good breakfast, clean rooms, good pool, spa and gym.
 Johnson Aug 20, 2014

$128

$128
Courtyard by Marriott San Diego Sorrento Valley

Courtyard by Marriott San Diego Sorrento Valley

9650 Scranton Rd, San Diego
3.5 out of 5.0
4.2 out of 5 (604 reviews)
Good choiceThis was a good choice for our San Diego stay. It's not directly at the beach, but everything is within 10-15 miles of driving distance. I would say most importantly that this hotel seemed very safe. It's in a business area so not many stores around, but there is a nice Indian restaurant close by. ...
 Dasha Apr 6, 2017

$116

$116
Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel

9310 Kearny Mesa Rd, San Diego
2.5 out of 5.0
3.8 out of 5 (935 reviews)
Good location to stay.A comfy, clean place to stay, close to the airport.
  Feb 13, 2018

$100

$100
HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa

10044 Pacific Mesa Blvd, San Diego
3.0 out of 5.0
4.5 out of 5 (1,243 reviews)
Staff was friendly and the room was amazing made you fell life home.
  Feb 19, 2018

$119

$119
Residence Inn San Diego Sorrento Mesa/Sorrento Valley

Residence Inn San Diego Sorrento Mesa/Sorrento Valley

5995 Pacific Mesa Ct, San Diego
3.0 out of 5.0
4.5 out of 5 (204 reviews)
Clean hotel Everything was great here, would stay here again in the future.
  Dec 19, 2017

$129

$129
Residence Inn By Marriott San Diego Central

Residence Inn By Marriott San Diego Central

5400 Kearny Mesa Rd, San Diego
3.5 out of 5.0
4.5 out of 5 (518 reviews)
Clean and nice overallClean room, but we didn’t have any liquid dish soap in the kitchen or spare blankets in the closet. It would have been nice so we could wash our dog food bowls between meals and use a blanket while watching tv o the sofa. Also, the standard dog fee is outrageous at $100 per night! Luckily we were ...
  Jan 15, 2018

$129

$129
Hilton Garden Inn San Diego Mission Valley Stadium

Hilton Garden Inn San Diego Mission Valley Stadium

3805 Murphy Canyon Rd, San Diego
3.0 out of 5.0
3.7 out of 5 (326 reviews)
Short for just a night but great!Our only concern was that we were not notified that breakfast was until 10:00 AM on New Year's january first, 2018. Hours were for a normal week day, which for a January 1st seems a little out of line, but this is by all means a friendly comment.
  Jan 2, 2018

$139

$139
Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley

Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley

5925 Lusk Blvd, San Diego
3.0 out of 5.0
4.4 out of 5 (581 reviews)
nice and quietgood hotel , nice staff and clean, quiet but far from center
  Jan 15, 2018

$106

$106
Holiday Inn San Diego North Miramar

Holiday Inn San Diego North Miramar

9335 Kearny Mesa Rd, San Diego
3.0 out of 5.0
4.2 out of 5 (423 reviews)
Needed a last minute hotel and found a discounted room here... good room for the price and area.
  Feb 12, 2018

$104

$104
Four Points by Sheraton San Diego

Four Points by Sheraton San Diego

8110 Aero Dr, San Diego
3.5 out of 5.0
3.6 out of 5 (1,266 reviews)
Nice, close to stadiumWe booked this hotel for our trip to watch the Cowboys vs. Chargers. The hotel was nice, the pool & spa was nice & secluded. And the rooms were clean, with very comfortable beds.
 Cassie Sep 30, 2013

$106

$106

Recently booked Resorts & Hotels with Spas in Central San Diego

Extended Stay America San Diego - Mission Valley - Stadium
2.5 out of 5.0
Last booking: 1 minute ago
Pleasant Inn
3.0 out of 5.0
Last booking: 59 minutes ago
California Suites Hotel
2.5 out of 5.0
Last booking: 1 hour ago
Extended Stay America San Diego - Sorrento Mesa
3.0 out of 5.0
Last booking: 1 hour ago
Ramada San Diego North Hotel and Conference Center
4.0 out of 5.0
Last booking: 1 hour ago
HYATT house San Diego/Sorrento Mesa
3.0 out of 5.0
Last booking: 1 hour ago
Quality Inn San Diego Miramar
3.0 out of 5.0
Last booking: 5 hours ago
Residence Inn By Marriott San Diego Central
3.5 out of 5.0
Last booking: 5 hours ago
Motel 6 San Diego North
2.5 out of 5.0
Last booking: 6 hours ago

Central San Diego Resorts & Spa Travel Guide

Pamper Yourself with a Spa Day in Central San Diego

Grab your suitcase and leave behind stress to jumpstart your tension-free vacation. If you are seeking for fashionable accommodations or budget-friendly options, we can assist you in finding the best location to stay. You'll find in encouraging you to take it easy. You deserve the royal treatment every now and then. Take the opportunity for a trip where you can let yourself be unconcerned with everything going on with your life in Central San Diego.

We Have Divine Spa Deals in Central San Diego

Not much compares to opening the door to your room and realizing all the little things will be taken care for you. Decompress and get settled in. After that you can book your first appointment to indulge yourself at a nearby spa. After you've indulged yourself by enjoying a massage, unwinding within the sauna, or lounging poolside, you can put on your explorer's cap and find the hidden gems of Central San Diego. Discovering incredible foods, curio shops, or a beautiful park can be one of the many highlights of your trip. If you're not sure where to begin, ask your hotel's front desk attendant to get an idea for what Central San Diego has to offer. There is no better source than a local to point you to an exciting evening out or to a cafe to grab a few cocktails at and mingle. Wherever your path takes you, just make sure to hang loose. Your spa holiday shouldn't be anything but exceptionally relaxing.

With so many ways to wind you down, Central San Diego ranks as one of the best spots for a spa vacation.