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Featured Central West End Luxury Hotels

See all 302 Hotels in Central West End
Holiday Inn Express St Louis - Central West End
4630 Lindell, St. Louis
Holiday Inn Express St Louis - Central West End
3.5/5 (389 reviews)

Very pleased with our stay... would stay again ! Great location, nice staff.

altText Apr 23, 2018
The Parkway Hotel
4550 Forest Park Ave, St. Louis
The Parkway Hotel
4.2/5 (1,503 reviews)

This hotel is in the perfect location right next to the hospital and close to a bunch of fun restaurants/bars! The staff was very friendly and the room was clean! We had no problems during our stay.

altText Apr 24, 2018

Recently booked Luxury Hotels in Central West End

Home2 Suites by Hilton St. Louis/Forest Park
2.5 out of 5.0
Last booking: 30 minutes ago
Holiday Inn Express St Louis - Central West End
3.0 out of 5.0
Last booking: 3 hours ago
The Parkway Hotel
3.0 out of 5.0
Last booking: 5 hours ago

A weekend away keeps your worries at bay, especially when you're enjoying a stay in Central West End. Exquisite eats, brilliant experiences, and the most breathtaking photo opportunities: these are just some of the things you'll discover in Central West End. Of course, you'll book a room at a luxury hotel! Extravagant experiences are right up your alley. While you're in town, you'll also devour delicious eats, get in line to see the coolest sites, and enjoy the most popular performances. Book your upscale hotel in Central West End on today and start your vacation off on the right (well-dressed) foot.

Booking Central West End Vacations

If you need any proof that Central West End is full of marvelous things to do, you should know that plenty of folks love it enough to have set down roots. No matter what brings you to Central West End, the destination always delivers. Central West End is full of comfy hotels as well as fantastic food, so you can count on a marvelous stay. Book well in advance to get the best room!

Any 5-star getaway begs for you to explore day spas, art, and local museums. When you save big by booking on, it's all at your fingertips. Thanks to our unbeatable rates on hotels, you'll still have money in your budget for the most fun and free-spirited activities. After a day of adventure, your luxury suite awaits. Take advantage of amenities like a concierge or indoor pool before the day is through. The luxury accommodations in Central West End will have you feeling the relaxation as soon as you check in.

Luxury Hotels in Central West End

When you’ve got your heart set on making the most of your grand vacation in Central West End, is here to save the day. Search through the wealth of ratings and reviews on spectacular hotels and find the perfect vacation rental. Luxury accommodations offer amenities like elegant suites and VIP services. Some of the city's deluxe accommodations even feature impeccable penthouses, while others boast exquisite in-room dining. Use our mobile booking app to choose a fabulous 5-star hotel in Central West End, and before you know it you'll be feeling blissful in paradise!