Title: Commerce Vacation Rentals from $140: Search Short-Term Rentals | Expedia.com [Hotels in Commerce](https://expedia.com/Commerce-Hotels.d553248634983177483.Travel-Guide-Hotels)[Car Rentals in Commerce](https://expedia.com/Car-Rentals-In-Commerce.d553248634983177483.Car-Rental-Guide)[Commerce Vacation Packages](https://expedia.com/Commerce.d553248634983177483.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/32a5a1b7-682e-4c22-a8ab-4b736795e0ea/expedia_fallback.webp?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/32a5a1b7-682e-4c22-a8ab-4b736795e0ea/expedia_fallback.webp?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates In two weeks [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=553248634983177483&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=553248634983177483&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=553248634983177483&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=553248634983177483&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Commerce vacation rentals ![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d4f180ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/13ed0134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d47379a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peaceful secluded cabin located near Horseshoe Lake [](https://www.expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) Miller City 10/10 Exceptional (21 reviews) "The cabin is perfect for a quiet getaway. Location is great close to Dollar General, gas station and restaurants" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marsha G. $174 nightly $184 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Little Blue Cottage on Spanish [](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) Cape Girardeau 8.2/10 Very Good (53 reviews) "Cozy and perfect for a couple. Great communication with the host" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beth G. $101 nightly $108 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/d70c82b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/73a1d2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/559581d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rested Duck Mallard Room [](https://www.expedia.com/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) Olive Branch 9.4/10 Exceptional (28 reviews) "This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mike b. $133 nightly $140 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/85f62077.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/3bc4c831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/52fdc4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy cabins on beautiful Horseshoe Lake [](https://www.expedia.com/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) Olive Branch 9.8/10 Exceptional (37 reviews) "The cabin was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin G. $133 nightly $140 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/b8327ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Twisted Sassafras Treehouse [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) Cape Girardeau 10/10 Exceptional (31 reviews) "This is the perfect private romantic getaway! We had such a blast here. Definitely recommend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric S. $302 nightly $317 total Mar 9 - Mar 10 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/211494f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool [](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) Cape Girardeau 8.8/10 Excellent (39 reviews) "Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily D. $208 nightly $219 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/5f66921b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0622af9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming Secluded Getaway Cabin within minutes of amenities [](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information) Cape girardeau 10/10 Exceptional (18 reviews) "We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy M. $292 nightly $307 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information) ![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/3619a392.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/bb974ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gorgeous 1856 Log Cabin, Completely Renovated [](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information) Jackson 10/10 Exceptional (3 reviews) "incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chandler G. $313 nightly $313 total Mar 11 - Mar 12 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/0e13dd89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space [](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information) Cape Girardeau 10/10 Exceptional (151 reviews) "Such a great place and location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy H. $229 nightly $248 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information) ![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/add99418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/2aecac3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Cottage, Rusted Route Farms [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information) Jackson 10/10 Exceptional (2 reviews) "This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee C. $196 nightly $196 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Game room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More [](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (8 reviews) "Nice place, great times" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jace W. $416 nightly $437 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/1c6c31ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/7dffb73b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/d39634e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/104000000/103900000/103892700/103892640/824c377e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Building at Cape Girardeau Regional Airport [](https://www.expedia.com/Scott-City-Hotels-Building-At-Cape-Girardeau-Regional-Airport.h103892640.Hotel-Information) Scott City $571 nightly $620 total Mar 7 - Mar 8 Total with taxes and fees [](https://www.expedia.com/Scott-City-Hotels-Building-At-Cape-Girardeau-Regional-Airport.h103892640.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-20&endDate=2026-03-21®ionId=553248634983177483&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_553248634983177483) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.com/Hotel-Search?destination=Commerce%2C+Missouri%2C+United+States+of+America®ionId=553248634983177483&latLong=37.158939%2C-89.442862&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=CABIN) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Commerce%2C+Missouri%2C+United+States+of+America®ionId=553248634983177483&latLong=37.158939%2C-89.442862&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=VACATION_HOME) Apartments [](https://www.expedia.com/Hotel-Search?destination=Commerce%2C+Missouri%2C+United+States+of+America®ionId=553248634983177483&latLong=37.158939%2C-89.442862&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=APARTMENT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCommerce-Vacation-Rentals.d553248634983177483.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCommerce-Vacation-Rentals.d553248634983177483.Travel-Guide-VacationRentals) ## Top Commerce Hotel Reviews ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 6/10 Okay "Pet friendly but charge a ridiculous amount of $75 Per pet!! Didn’t disclose untill check on. " [](https://expedia.com/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "Everything was excellent. Staff was very friendly and helpful." [](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "This was our first time staying at a Drury Hotel. The room was clean and comfortable! We missed the evening snack, but breakfast was awesome! So many options. Would definitely stay again!" [](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Great as all Drury’s" [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg) ### Quality Inn Cape Girardeau North 4/10 Poor "Noisy. Could hear noise from parking lot and from upstairs. Did not like required refundable $50 deposit. After hearing a shower running from another room, our shower leaked from the wall connection. Staff said there was no one available to fix. Staff offered to move us. but we were unpacked ready to sleep. Bathroom light flickered while shower was dripping.. Aging facility." [](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "Clean , friendly, great location " [](https://expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Plenty of good parking. Good food choices nearby. Very comfortable rooms" [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Fairfield Inn & Suites by Marriott Cape Girardeau](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe_y.jpg) ### Fairfield Inn & Suites by Marriott Cape Girardeau 10/10 Excellent "Staff was wonderful" [](https://expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Country Yard Inn and Suite](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a_y.jpg) ### Country Yard Inn and Suite 10/10 Excellent "I love this hotel." [](https://expedia.com/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) ## Find out more about Commerce **Everything you need to know about Commerce vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Commerce vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Commerce vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Commerce vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Commerce. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Commerce in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $140 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Commerce rentals** At Expedia, we put the best Commerce vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Commerce rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Commerce vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Commerce. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Commerce ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals) - [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals) - [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals) - [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals) - [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals) - [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals) - [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals) - [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals) - [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals) - [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals) - [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals) - [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations) - [Vacation Homes in Commerce ](https://expedia.com/Commerce-Private-Vacation-Homes.d553248634983177483-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Apartments in Commerce ](https://expedia.com/Commerce-Apartments.d553248634983177483-aaApartments.Travel-Guide-Accommodation) - [Cabin Rentals in Commerce ](https://expedia.com/Commerce-Cabins.d553248634983177483-aaCabins.Travel-Guide-Accommodation) - [Motels in Commerce ](https://expedia.com/Commerce-Motels.d553248634983177483-aaMotels.Travel-Guide-Accommodation) - [RV Parks in Commerce ](https://expedia.com/Commerce-RV-Parks.d553248634983177483-aaRVParks.Travel-Guide-Accommodation) - [Farmstay in Commerce ](https://expedia.com/Commerce-Agritourism.d553248634983177483-aaAgritourism.Travel-Guide-Accommodation) - [B&B in Commerce ](https://expedia.com/Commerce-Bed-And-Breakfast.d553248634983177483-aaBedAndBreakfast.Travel-Guide-Accommodation) ## Frequently asked questions ### Are there vacation rentals in Commerce? ### What's the top vacation rental in Commerce? ### What’s there to see and do in Commerce? ### What’s a vacation rental in Commerce like?