De Soto Vacations from $491
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Your De Soto Vacation
Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.
The Latest De Soto vacation packages
Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
Save 100% on your flight
Price was $762, price is now $491 per person
$491
per person
Apr 20 - Apr 27
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8/10 Very Good! (1,004 reviews)
Centrally located, great park and fly, breakfast is great. The only thing I do not like is for police officers to park outside and go to eat breakfast. It appears that there is trouble at the hotel.
Reviewed on Mar 9, 2026
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Save 100% on your flight
Price was $1,199, price is now $765 per person
$765
per person
Apr 20 - Apr 27
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,060 reviews)
The property was beautiful and unique. The food was a disappointment. Unfortunately it was just too greasy for us.
Reviewed on Mar 6, 2026
The Knight Center at Washington University
Save 100% on your flight
Price was $996, price is now $666 per person
$666
per person
Apr 20 - Apr 27
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (486 reviews)
The property locates on campus, convenient location.
Newly renovated, quiet and clean.
It would be great if the hotel can provide day time hot coffee in the lobby.
Reviewed on Mar 9, 2026
De Soto Hotel Deals
82 Acre Hobby Farm with Lincoln Log Cabin
De Soto MO
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...
Reviewed on Dec 8, 2025
Secluded cabin on private property
De Soto MO
10/10 Exceptional! (65 reviews)
Love this property. Will be back.
Reviewed on Mar 8, 2026
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Mar 22 to Mar 23
$104 total
Mar 22 - Mar 23
Total with taxes and fees
9.4/10 Exceptional! (1,011 reviews)
Parking was comfortable and safe to park. We always stay at this site because of the cleanliness and very comfortable beds! Breakfast is wonderful!
Reviewed on Mar 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best De Soto Vacation Packages
De Soto Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 6,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 90ºF |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.