De Soto Vacations from $506
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Your De Soto Vacation
Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.
The Latest De Soto vacation packages
Price found within the past 48 hours. Click for updated prices.
Spacious 3-Bedroom with King Bed
Central West End
Price was $1,207, price is now $937 per person
$937
per person
Mar 27 - Mar 30
found 10 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.6/10 Excellent! (10 reviews)
Overall, we loved the apartment. It was cute, beds were very comfortable.
Reviewed on May 8, 2025
Ameristar Casino Resort and Spa
Price was $861, price is now $708 per person
$708
per person
Feb 20 - Feb 23
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to St. Louis (STL)
8.4/10 Very Good! (1,006 reviews)
From check-in to check-out the staff was extremely professional, friendly, and courteous. The room was fabulous. It was clean and so spacious. A sunken sitting area was an added bonus. We had a view of the river and the bridge. My expectations were definitely exceeded. The only thing that was frustrating was the internet coverage. Our Internet was very limited. I had to go elsewhere to get a good Internet signal. I only had LTE coverage.
Reviewed on Dec 28, 2025
De Soto Hotel Deals
82 Acre Hobby Farm with Lincoln Log Cabin
De Soto MO
$257 nightly
The price is $266 total per night from Jan 3 to Jan 4
$266 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
10/10 Exceptional! (40 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...
Reviewed on Dec 8, 2025
Secluded cabin on private property
De Soto MO
10/10 Exceptional! (62 reviews)
A beautiful and comfy property with plenty of space inside and out. Well marked paths through the property made it easy to traipse through the woods. And a surprise cup of hot cocoa after a chilly day doing just that was just icing on the cake (no cake though…).
Reviewed on Nov 30, 2025
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Jan 5 to Jan 6
$104 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
9.2/10 Wonderful! (1,004 reviews)
Great stay
Reviewed on Dec 27, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best De Soto Vacation Packages
De Soto Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 6,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 90ºF |
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