De Soto Vacations from $432

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $636, price is now $432 per person
$432
per person
May 11 - May 14
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Great staff. Safe place within walking distance of restaurants and activities. Clean room.

Reviewed on Feb 19, 2026

Landing Apartments - Eureka

Landing Apartments - Eureka

4 out of 5
Save 100% on your flight
Price was $1,331, price is now $1,004 per person
$1,004
per person
Apr 8 - Apr 13
found 10 hours ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
No reviews
Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Save 100% on your flight
Price was $1,270, price is now $977 per person
$977
per person
Apr 8 - Apr 13
found 10 hours ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.6/10 Excellent! (10 reviews)
Clean room nice area

Reviewed on Feb 1, 2026

The Cheshire

The Cheshire

4 out of 5
Price was $769, price is now $625 per person
$625
per person
Apr 24 - Apr 27
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.6/10 Excellent! (1,002 reviews)
Room was great breakfast was great

Reviewed on Feb 14, 2026

St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
Downtown West
Price was $969, price is now $799 per person
$799
per person
May 11 - May 14
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.4/10 Very Good! (1,001 reviews)
There is so much to do in this little spot. So much history to walk around and look at inside the hotel and outside.

Reviewed on Feb 12, 2026

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De Soto Hotel Deals

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
$257 nightly
The price is $266 total per night from Feb 23 to Feb 24
$266 total
Feb 23 - Feb 24
Total with taxes and fees
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (63 reviews)
This place was fantastic! Just pack your clothes and food—everything else is provided. We truly enjoyed our stay at the cabin and can’t wait to return. Thank you for the great hospitality.

Reviewed on Jan 2, 2026

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Secluded cabin on private property
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$56 nightly
The price is $64 total per night from Feb 28 to Mar 1
$64 total
Feb 28 - Mar 1
Total with taxes and fees
8/10 Very Good! (1,000 reviews)
Great staff and nice accommodations

Reviewed on Feb 16, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
See all 182 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best De Soto Vacation Packages

De Soto Essential Information

Language
English
Currency
U.S dollars
Population
6,500
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a De Soto vacation package cost?
Offering excellent value package deals from $432 on Expedia, you'll be surprised at how little a vacation to De Soto costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to De Soto?
If you're looking to score a cheap De Soto vacation package, consider planning a trip in June, October and November. You're likely to find lower prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for De Soto?
Generally, a handful of days is enough to tick off the top sights during your De Soto vacation. However, if you'd like to have time to relax or take day tours, think about extending your trip.
How to find the best De Soto package deals?
Use Expedia's filters to help you find some tempting De Soto package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for De Soto package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a De Soto vacation as a package?
You can enjoy significant savings on your next De Soto retreat by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to De Soto?
If you're considering a spontaneous De Soto adventure, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land terrific deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later De Soto vacation packages?
Set off on your dream trip to De Soto with help from our Book Now, Pay Later vacations. No need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snap up cheap deals before they sell out.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.