De Soto Vacations from $319
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Your De Soto Vacation
Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.
The Latest De Soto vacation packages
Price found within the past 48 hours. Click for updated prices.
White House at Grand Central
Grand Center
Price was $610, price is now $428 per person
$428
per person
Dec 28 - Jan 1
found 22 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to St. Louis (STL)
8.4/10 Very Good! (121 reviews)
It was very easy to access public transportation from this property. The room was very clean, bed was comfortable, and when the hot water got up there it was plentiful and hot. There were a/c and heat available; I used both and each worked fine. My apartment was on third floor, and was accessible only via stairs. It was not a problem for me (it was a workout!), but might be for more physically-impaired folks.
Reviewed on Oct 23, 2025
Spacious 3-Bedroom with King Bed
Central West End
Price was $1,035, price is now $827 per person
$827
per person
Dec 23 - Dec 26
found 9 hours ago
Roundtrip flight included
Houston (HOU) to St. Louis (STL)
8.6/10 Excellent! (10 reviews)
Overall, we loved the apartment. It was cute, beds were very comfortable.
Reviewed on May 8, 2025
De Soto Hotel Deals
82 Acre Hobby Farm with Lincoln Log Cabin
De Soto
$257 nightly
The price is $266 total per night from Oct 27 to Oct 28
$266 total
Oct 27 - Oct 28
Total with taxes and fees
10/10 Exceptional! (39 reviews)
The cabin was wonderful with many extras like snacks and coffee.
Reviewed on Oct 18, 2025
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
4800 U.S. Highway 67, De Soto, MO
9.4/10 Exceptional! (153 reviews)
Breakfast
Take the breakfast picture off the website. It said free breakfast for 2 adults but they stopped doing breakfast awhile back
Reviewed on Sep 12, 2025
Secluded cabin on private property
De Soto
10/10 Exceptional! (58 reviews)
Very clean inside. The host was responsive to questions in messaging on the app. Crystal laden rocks abound just laying on the forest floor on the property. We had a good time with the family there while we were in town for our niece's wedding at the nearby Hillsboro winery. Very quite and peaceful ...
Reviewed on Sep 23, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best De Soto Vacation Packages
De Soto Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 6,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 90ºF |
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