De Soto Vacations from $533

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $1,044, price is now $533 per person
$533
per person
Jan 27 - Feb 3
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Clean quiet room. Friendly staff

Reviewed on Dec 8, 2025

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Save 100% on your flight
Price was $772, price is now $553 per person
$553
per person
Jan 27 - Feb 3
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
8.2/10 Very Good! (779 reviews)
Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!

Reviewed on Oct 26, 2025

DoubleTree by Hilton Hotel St. Louis - Chesterfield

DoubleTree by Hilton Hotel St. Louis - Chesterfield

4 out of 5
Save 100% on your flight
Price was $877, price is now $634 per person
$634
per person
Jan 27 - Feb 3
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
8.6/10 Excellent! (1,001 reviews)
Clean rooms, comfortable beds, kind and helpful staff such as Kim, Brandon at the front desk, Michelle our house keeper were all fantastic.

Reviewed on Nov 26, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Save 100% on your flight
Price was $858, price is now $629 per person
$629
per person
Jan 27 - Feb 3
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
8.8/10 Excellent! (1,022 reviews)
The room smelled like sewer gas or car exhaust. I ran water in the shower and that seemed to eliminate the smell. Air return filter was way past the time to change it. The room and beds were lovely but I need better lighting. Not enough choices for tv viewing. Lotions and soaps were nice. Loved the scent.

Reviewed on Dec 6, 2025

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Save 100% on your flight
Price was $942, price is now $693 per person
$693
per person
Jan 27 - Feb 3
found 1 day ago
Roundtrip flight included
Charlotte (CLT) to St. Louis (STL)
9.4/10 Exceptional! (425 reviews)
Staff was warm and helpful.

Reviewed on Dec 8, 2025

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De Soto Hotel Deals

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
$257 nightly
The price is $266 total per night from Dec 10 to Dec 11
$266 total
Dec 10 - Dec 11
Total with taxes and fees
10/10 Exceptional! (40 reviews)
The cabin was wonderful with many extras like snacks and coffee.

Reviewed on Oct 18, 2025

82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (61 reviews)
A beautiful and comfy property with plenty of space inside and out. Well marked paths through the property made it easy to traipse through the woods. And a surprise cup of hot cocoa after a chilly day doing just that was just icing on the cake (no cake though…).

Reviewed on Nov 30, 2025

Get rates
Secluded cabin on private property
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Dec 13 to Dec 14
$104 total
Dec 13 - Dec 14
Total with taxes and fees
9.2/10 Wonderful! (1,001 reviews)
Very nice overall. Beds were comfy, AC worked well, good water pressure for showers. If I am being nit-picky… the waffle syrup had no maple flavor at all. I don’t expect 100% Canadian maple syrup, but the syrup just tasted like corn syrup.

Reviewed on Nov 30, 2025

Pear Tree Inn St. Louis Arnold
See all 170 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best De Soto Vacation Packages

De Soto Essential Information

Language
English
Currency
U.S dollars
Population
6,500
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a De Soto vacation package cost?
Offering excellent value package deals from $533 on Expedia, you'll be surprised at how little a vacation to De Soto costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to De Soto?
If you're looking to score a cheap De Soto vacation package, consider planning a trip in June, October and November. You're likely to find lower prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for De Soto?
Generally, a handful of days is enough to tick off the top sights during your De Soto vacation. However, if you'd like to have time to relax or take day tours, think about extending your trip.
How to find the best De Soto package deals?
Use Expedia's filters to help you find some tempting De Soto package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for De Soto package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a De Soto vacation as a package?
You can enjoy significant savings on your next De Soto retreat by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to De Soto?
If you're considering a spontaneous De Soto adventure, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land terrific deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later De Soto vacation packages?
Set off on your dream trip to De Soto with help from our Book Now, Pay Later vacations. No need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snap up cheap deals before they sell out.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.