
De Soto Vacations from $291
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Your De Soto Vacation
Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.
The Latest De Soto vacation packages
Price found within the past 48 hours. Click for updated prices.


Ballpark Apartments by Barsala
Downtown St. Louis
per person
Aug 15 - Aug 17
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to St. Louis (STL)
7.2/10 Good! (7 reviews)
It's a great location, right across from the Ballpark. It is a fairly spartan apartment set-up, with concrete floors.. a little surprising? Parking is on the street or in a pay lot.
Reviewed on Jun 8, 2025


Spacious 3-Bedroom with King Bed
Central West End
Save 100% on your flight
per person
Aug 7 - Aug 11
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to St. Louis (STL)
9.2/10 Wonderful! (9 reviews)
Overall, we loved the apartment. It was cute, beds were very comfortable.
Reviewed on May 8, 2025

Ameristar Casino Resort and Spa
per person
Sep 16 - Sep 18
found 5 hours ago
Roundtrip flight included
Las Vegas (LAS) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
Unacceptable that for this price,
NO MICROWAVE IN ROOM!
Also under 21 not allowed in any pool at anytime! So do not come here with your Family! Also, only a couple Resteraunts allow kids
Reviewed on Jul 1, 2025
De Soto Hotel Deals

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
4800 U.S. Highway 67, De Soto, MO
Fully refundable
$161 nightly
The price is $172 total per night from Jul 20 to Jul 21
$172 total
Jul 20 - Jul 21
Total includes taxes and fees
9.2/10 Wonderful! (145 reviews)
"Lots of activity’s for Adults and children. Great property. Rooms were nice."
Reviewed on Jul 3, 2025

82 Acre Hobby Farm with Lincoln Log Cabin
De Soto
$269 nightly
The price is $279 total per night from Jul 28 to Jul 29
$279 total
Jul 28 - Jul 29
Total includes taxes and fees
10/10 Exceptional! (37 reviews)
Comfy and peaceful
"Had a great stay enjoyed the beds, porches and the chickens. Great mornings listening to the birds."
Reviewed on Jun 1, 2025

Secluded cabin on private property
De Soto
10/10 Exceptional! (51 reviews)
"Beautiful quiet setting nice property"
Reviewed on Jun 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best De Soto Vacation Packages
De Soto Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Population | 6,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 90ºF |
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