
De Soto Vacations from $311
Book a Hotel + Flight or Car together to unlock savings
Photo by Jessica King
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your De Soto Vacation
Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.
The Latest De Soto vacation packages
Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel
Save 100% on your flight
Price was $494, price is now $311 per person
$311
per person
May 4 - May 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
Well, right off the bat, the parking situation was a little bit confusing. My gps took me to a large empty parking lot in the back of the building. Since there were no cars parked there nor an entrance accessible from there, I pulled around the building. There was a small circle driveway off an intersection and some street parking. I kept going and found a parking garage. I got out and walked to the door and there was a sign saying no hotel access, use other door. I went to the second door, got out and there was another small note saying this entrance is closed please use the other door. Finally I found a third door that did access the hotel but only with a key card, so we had to walk up to the front of the hotel to check in and then go get our bags after. No problem. We get to our room.. lovely room, but unfortunately it hadn’t been cleaned. There was trash, the beds were unmade, dirty towels in the bathroom, obviously had not been cleaned at all. Went to front desk, they moved us to a downgraded room but wouldn’t give us any sort of discount or even apology. Okay. Whatever.
The room we went to was fine, but no balcony. The shower head needed replacing, had a weird weak stream, was clogged. I had to twist it to get the water to shoot out of the middle holes, thankfully that worked ok. Breakfast was alright, the standard continental breakfast fare. Waffle irons, etc. Pool and hot tub area was crowded. Desk staff nice. Pictures were misleading on site imo. But not bad hotel.
Reviewed on Mar 30, 2026

The Cheshire
Price was $492, price is now $362 per person
$362
per person
May 4 - May 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
The room was comfortable and we had the amenities we needed. It offered a generous breakfast every morning. Coffee and water were available at all times. The gym was clean and easily accessible. The pool was closed during our stay due to the season we traveled in. There was ample parking downstairs. The bar on site was really cute and the drinks were great. We were driving distance to a lot of things and it made it a great homebase. We would definitely stay here again.
Reviewed on Mar 29, 2026

Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Price was $953, price is now $710 per person
$710
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,029 reviews)
The only major drawback occurred over the weekend when one of the main elevators went out of service. While mechanical issues are understandable, the lack of communication was frustrating. There was no signage posted at the elevator banks to alert guests or direct them to the service stairs/alternative lifts. This led to a lot of confusion and long wait times in the lobby, which took away from the otherwise seamless "vibe" of the hotel. I would definitely recommend this hotel for its excellent location and superb staff. If they can improve their internal communication and guest signage during maintenance issues, it would easily be a five-star stay.
Reviewed on Mar 29, 2026

The Knight Center at Washington University
Price was $791, price is now $595 per person
$595
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (496 reviews)
Great, simple breakfast options. Clean fitness room. Terrific location steps from main campus and a short walk to town and restaurants.
Reviewed on Mar 26, 2026

De Soto Hotel Deals

Secluded cabin on private property
De Soto MO
10/10 Exceptional! (67 reviews)
had everything we needed everyone enjoyed them self
Reviewed on Mar 30, 2026

82 Acre Hobby Farm with Lincoln Log Cabin
De Soto MO
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...
Reviewed on Dec 8, 2025

Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Apr 4 to Apr 5
$104 total
Apr 4 - Apr 5
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
Clean room, comfortable bed, free breakfast & plenty of fast food places nearby
Reviewed on Mar 23, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best De Soto Vacation Packages
De Soto Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Population | 6,500 |
Max Temp Winter | 45ºF |
Max Temp Summer | 90ºF |
More vacations you might like
Frequently asked questions
Explore a world of travel with Expedia
- Hematite Hotels
- Condo Resorts in Hematite
- Hillsboro Hotels
- Cabin Rentals in Hillsboro
- Drury Inn & Suites Hotels in Hillsboro
- 3 Star Hotels in Hillsboro
- Vacation Homes in Hillsboro
- Condo Rentals in Hillsboro
- Apartments in Hillsboro
- Motels in Hillsboro
- Villas in Hillsboro
- Hotels near Washington State Park
- Tiff Hotels
- B&B in Tiff
- Cabin Rentals in Tiff
- Lodges in Tiff
- 5 Star Hotels in Tiff
- Festus Hotels
- Drury Inn & Suites Hotels in Festus
- Cheap Hotels in Festus
- Pet-Friendly Hotels in Festus
- Motels in Festus
- Hotels with an Indoor Pool in Festus
- Hotels with Restaurants in Festus
- Hotels with a Pool in Festus
- B&B in Festus
- Hotels with smoking rooms in Festus
- Hotel Wedding Venues Hotels in Festus
- Hotels with Connecting Rooms in Festus
- Hotels with Bars in Festus
- Villas in Festus
- Hotels with an Outdoor Pool in Festus
- Gay friendly Hotels in Festus
- Cabin Rentals in Festus
- Vacation Homes in Festus
- 3 Star Hotels in Festus
- Hotels with Free Breakfast in Festus
- Luxury Hotels in Festus
- Hotels with Air Conditioning in Festus
- Hotels with Laundry Facilities in Festus
- 4 Star Hotels in Festus
- Resorts & Hotels with Spas in Festus
- 5 Star Hotels in Festus
- Wyndham Hotels in Festus
- Hotels & Resorts for Couples in Festus
- Best Western Hotels in Festus
- Condo Rentals in Festus
- Family Hotels in Festus
- Rv Parks in Festus
- Hotels near Villa Antonio Winery
- Hotels near Sandy Creek Covered Bridge State Historic Site
- Crystal City Hotels
- Valles Mines Hotels
- Hotels near St. Francois State Park
- Dittmer Hotels
- Herculaneum Hotels
- Vacation Homes in Dittmer
- 5 Star Hotels in Dittmer
- Motels in Dittmer
- Car rentals near Olympian Village
- Car rentals near Hematite
- Car rentals near Hillsboro
- Car rentals near Mapaville
- Car rentals near Tiff
- Economy Car Rentals in Tiff
- Sixt Rental Cars in Tiff
- Europcar Rental Cars in Tiff
- Car rentals near Festus
- Enterprise Rental Cars in Festus
- Van Car Rentals in Festus
- Hertz Rental Cars in Festus
- Minivan Car Rentals in Festus
- Car rentals near Morse Mill
- Car rentals near Horine
- Car rentals near Crystal City
- Car rentals near Valles Mines
- Car rentals near St. Francois State Park
- Car rentals near Herculaneum
- Car rentals near Dittmer
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.



















