De Soto Vacations from $620

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $905, price is now $620 per person
$620
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
the hotel is very comfortable and the staff was very helpful.

Reviewed on Mar 20, 2026

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
Price was $1,242, price is now $939 per person
$939
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9/10 Wonderful! (1,005 reviews)
The property was well maintained, and everybody was very helpful polite the day was phenomenal. We couldn’t ask for anything else. It was great.

Reviewed on Mar 17, 2026

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was $923, price is now $719 per person
$719
per person
Jun 16 - Jun 20
found 19 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
Overall it was a positive experience but we were VERY disappointed when we found out our daughter couldn’t swim all weekend. We would not have booked it if we had known that.

Reviewed on Mar 22, 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Price was $986, price is now $769 per person
$769
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.4/10 Exceptional! (496 reviews)
Great place to stay on campus. Extremely helpful and friendly staff you don’t typically find at the chain hotels.

Reviewed on Mar 14, 2026

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Price was $1,377, price is now $1,080 per person
$1,080
per person
Jun 16 - Jun 20
found 17 hours ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area

Reviewed on Feb 1, 2026

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De Soto Hotel Deals

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

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82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (66 reviews)
Very private location with all the amenities.

Reviewed on Mar 13, 2026

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Secluded cabin on private property
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Mar 29 to Mar 30
$104 total
Mar 29 - Mar 30
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Several places to eat and shop nearby

Reviewed on Mar 22, 2026

Pear Tree Inn St. Louis Arnold
See all 183 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best De Soto Vacation Packages

De Soto Essential Information

Language
English
Currency
U.S dollars
Population
6,500
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a De Soto vacation package cost?
Offering excellent value package deals from $620 on Expedia, you'll be surprised at how little a vacation to De Soto costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to De Soto?
If you're looking to score a cheap De Soto vacation package, consider planning a trip in June, October and November. You're likely to find lower prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for De Soto?
Generally, a handful of days is enough to tick off the top sights during your De Soto vacation. However, if you'd like to have time to relax or take day tours, think about extending your trip.
How to find the best De Soto package deals?
Use Expedia's filters to help you find some tempting De Soto package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for De Soto package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a De Soto vacation as a package?
You can enjoy significant savings on your next De Soto retreat by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to De Soto?
If you're considering a spontaneous De Soto adventure, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land terrific deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later De Soto vacation packages?
Set off on your dream trip to De Soto with help from our Book Now, Pay Later vacations. No need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snap up cheap deals before they sell out.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.