Title: De Soto Vacation Packages 2026 from $495 | Expedia.com

[De Soto Travel Guide](https://expedia.com/De-Soto.dx6085105)[Hotels in De Soto](https://expedia.com/De-Soto-Hotels.d6085105.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.com/De-Soto-Vacation-Rentals.d6085105.Travel-Guide-VacationRentals)[Flights to De Soto](https://expedia.com/Cheap-Flights-To-De-Soto.d6085105.Travel-Guide-Flights)[Car Rentals in De Soto](https://expedia.com/Car-Rentals-In-De-Soto.d6085105.Car-Rental-Guide)

![](https://images.trvl-media.com/place/6085105/405982b2-f4d7-475b-927f-02fc53f853d1.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# De Soto Vacations from $495

## Book a Hotel + Flight or Car together to unlock savings

Photo by Jessica King

## Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with [Victoria Glaces Conservation Area Trailhead](https://www.expedia.com/Victoria-Glaces-Conservation-Area-Trailhead-Farmington.d641530574284017664.Vacation-Attraction). No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

## The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.

![Motel 6 Troy, IL](https://images.trvl-media.com/lodging/1000000/490000/486900/486803/acdbf100_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Motel 6 Troy, IL

$495

per person

Apr 25 - May 2

found 1 day ago

Roundtrip flight included

Phoenix (PHX) to St. Louis (STL)

7.6/10 Good! (525 reviews)

We chose this hotel because at 10 p.m. we were looking for someplace to sleep that was inexpensive. Leaving next morning. It was definitely minimalistic. Front desk man was polite. We could not find tv remote and he gave us another one. Still couldn’t get any audio out of tv. Bathtub was not as clean as should be. Towels were very thin. No amenities at all. Two tiny bars of soap for sink and bath. Bed was ok. King bed with 3 small pillows. Fairly clean otherwise. They had coffee in the a.m. Have to say for $30 more could’ve had a much better room close by.

Reviewed on Dec 30, 2025

![The Principal Hotel](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/5d07ff1f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### The Principal Hotel

$795

per person

Apr 25 - May 2

found 1 day ago

Roundtrip flight included

Phoenix (PHX) to St. Louis (STL)

9.8/10 Exceptional! (175 reviews)

This was of the most cleanest and unique hotel! I loved the lockers painted as books! The detention Hall bar and metal small locker bed side table in the room. The bed is SUPER comfortable!! The restaurant - the graphite was phenomenal.. loved the creative menu to go with hotel. We will recommend this hotel to everyone!! Outstanding staff as well.. not mean none in hotel or restaurant! Thank you all!!

Reviewed on Mar 2, 2026

![Hotel Saint Louis, Autograph Collection](https://images.trvl-media.com/lodging/28000000/27480000/27478600/27478599/8a12cc18_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel Saint Louis, Autograph Collection

Downtown St. Louis

$672

per person

Apr 10 - Apr 12

found 1 day ago

Roundtrip flight included

Boston (BOS) to St. Louis (STL)

8.8/10 Excellent! (458 reviews)

Great Luxury Hotel and location.

Reviewed on Mar 4, 2026

![Landing Apartments - Eureka](https://images.trvl-media.com/lodging/120000000/119980000/119975900/119975875/80055f3d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Landing Apartments - Eureka

$1,125

per person

Apr 21 - Apr 25

found 1 day ago

Roundtrip non-stop flight included

Los Angeles (LAX) to St. Louis (STL)

No reviews

![Four Seasons Hotel St Louis](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/ef7a5612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Four Seasons Hotel St Louis

Downtown St. Louis

Save 100% on your flight

$2,010

per person

May 16 - May 23

found 16 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

9.4/10 Exceptional! (1,000 reviews)

Beautiful accommodations. Attentive and genuine staff. We felt like celebrities. Beyond first class service!!

Reviewed on Feb 23, 2026

Don't see what you're looking for?

See all available trips from Columbus to De Soto

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-05/2026-04-12/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=STL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6085105)

## De Soto Hotel Deals

![82 Acre Hobby Farm with Lincoln Log Cabin](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/664fb1e9_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

82 Acre Hobby Farm with Lincoln Log Cabin

 De Soto MO

10/10 Exceptional! (41 reviews)

The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F19%2F2026&endDate=3%2F20%2F2026&selected=73274691&PinnedHotelID=73274691&HadPinnedHotel=true&regionId=6085105)

[](https://expedia.com/Hotel-Search?startDate=3%2F19%2F2026&endDate=3%2F20%2F2026&selected=73274691&PinnedHotelID=73274691&HadPinnedHotel=true&regionId=6085105)

![Secluded cabin on private property](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/4f23eae6_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Secluded cabin on private property

 De Soto MO

10/10 Exceptional! (64 reviews)

We absolutely loved this little slice of heaven . We will be definitely be coming back later this summer

Reviewed on Feb 23, 2026

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F19%2F2026&endDate=3%2F20%2F2026&selected=89989748&PinnedHotelID=89989748&HadPinnedHotel=true&regionId=6085105)

[](https://expedia.com/Hotel-Search?startDate=3%2F19%2F2026&endDate=3%2F20%2F2026&selected=89989748&PinnedHotelID=89989748&HadPinnedHotel=true&regionId=6085105)

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$66 total

Mar 12 - Mar 13

Total with taxes and fees

8/10 Very Good! (1,006 reviews)

Went down to eat breakfast. The eggs were liquid and uncooked. Then went to get gravy for biscuts and gravy we found a long hair in the gravy. We have stayed here before and never had this issue. The beds do sleep great

Reviewed on Mar 3, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F12%2F2026&endDate=3%2F13%2F2026&selected=16153&PinnedHotelID=16153&HadPinnedHotel=true&regionId=6085105)

[See all 183 properties in De Soto](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F6%2F2026&endDate=3%2F7%2F2026&regionId=6085105)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best De Soto Vacation Packages

## De Soto Essential Information

| Language        | English     |
| --------------- | ----------- |
| Currency        | U.S dollars |
| Population      | 6,500       |
| Max Temp Winter | 45ºF        |
| Max Temp Summer | 90ºF        |

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## Frequently asked questions

### How much does a De Soto vacation package cost?

### What are the cheapest months to go to De Soto?

### How many days is enough for De Soto?

### How to find the best De Soto package deals?

### Is it cheaper to book a De Soto vacation as a package?

### When to book a vacation package to De Soto?

### Does Expedia offer Book Now, Pay Later De Soto vacation packages?

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- [Hillsboro Vacation Rentals ](https://www.expedia.com/Hillsboro-Vacation-Rentals.d6354549.Travel-Guide-VacationRentals)
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\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.