De Soto Vacations from $660

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $905, price is now $660 per person
$660
per person
Apr 30 - May 4
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to St. Louis (STL)
8.8/10 Excellent! (1,065 reviews)
Love how fun the hotel was. There is an art museum downstairs then the rooms are all colorful and so beautiful. The rooftop bar is next level and chill. They have comfy couches and go drinks and food with a wonderful view. Would 10/10 recommend staying here. Only downside is there’s no included breakfast but there is yummy restaurants near by.

Reviewed on Mar 31, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $1,523, price is now $964 per person
$964
per person
Jun 11 - Jun 17
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
The breakfaat was average, thou fresh. There was enough street parking nearby, safe.

Reviewed on Mar 30, 2026

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
Price was $1,429, price is now $1,066 per person
$1,066
per person
Jun 11 - Jun 17
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
9/10 Wonderful! (1,005 reviews)
Beautiful hotel, enjoyed the theater. Only problem was getting receipt for my boss.

Reviewed on Mar 31, 2026

The Cheshire

The Cheshire

4 out of 5
Price was $1,263, price is now $943 per person
$943
per person
Jun 11 - Jun 17
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
The room was comfortable and we had the amenities we needed. It offered a generous breakfast every morning. Coffee and water were available at all times. The gym was clean and easily accessible. The pool was closed during our stay due to the season we traveled in. There was ample parking downstairs. The bar on site was really cute and the drinks were great. We were driving distance to a lot of things and it made it a great homebase. We would definitely stay here again.

Reviewed on Mar 29, 2026

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Save 100% on your flight
Price was $1,184, price is now $909 per person
$909
per person
Jun 11 - Jun 14
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area

Reviewed on Feb 1, 2026

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De Soto Hotel Deals

Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (67 reviews)
had everything we needed everyone enjoyed them self

Reviewed on Mar 30, 2026

Get rates
Secluded cabin on private property
82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

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82 Acre Hobby Farm with Lincoln Log Cabin
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Apr 5 to Apr 6
$104 total
Apr 5 - Apr 6
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
Clean room, comfortable bed, free breakfast & plenty of fast food places nearby

Reviewed on Mar 23, 2026

Pear Tree Inn St. Louis Arnold
See all 182 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best De Soto Vacation Packages

De Soto Essential Information

Language
English
Currency
U.S dollars
Population
6,500
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a De Soto vacation package cost?
Offering excellent value package deals from $660 on Expedia, you'll be surprised at how little a vacation to De Soto costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to De Soto?
If you're looking to score a cheap De Soto vacation package, consider planning a trip in June, October and November. You're likely to find lower prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for De Soto?
Generally, a handful of days is enough to tick off the top sights during your De Soto vacation. However, if you'd like to have time to relax or take day tours, think about extending your trip.
How to find the best De Soto package deals?
Use Expedia's filters to help you find some tempting De Soto package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for De Soto package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a De Soto vacation as a package?
You can enjoy significant savings on your next De Soto retreat by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to De Soto?
If you're considering a spontaneous De Soto adventure, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land terrific deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later De Soto vacation packages?
Set off on your dream trip to De Soto with help from our Book Now, Pay Later vacations. No need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snap up cheap deals before they sell out.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.