De Soto Vacations from $506

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $993, price is now $506 per person
$506
per person
Mar 9 - Mar 15
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
Room was very fun layout. Grocery store and restaurants near by. Pool was very small but we didn't use the pool. Staff was great.

Reviewed on Jan 25, 2026

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Save 100% on your flight
Price was $717, price is now $529 per person
$529
per person
Mar 9 - Mar 15
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.2/10 Very Good! (779 reviews)
Staff was informative during check-in. Room was clean and the TV even had WELCOME with my name on it. Would stay here again.

Reviewed on Dec 22, 2025

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

2.5 out of 5
Woodson Terrace
Save 100% on your flight
Price was $902, price is now $681 per person
$681
per person
Mar 9 - Mar 15
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (96 reviews)
Great new hotel with full breakfast!

Reviewed on Jan 18, 2026

The Cheshire

The Cheshire

4 out of 5
Price was $677, price is now $513 per person
$513
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,002 reviews)
Staff was friendly and parking free and easy. The location near Forest Park is great if a trip to the St. Louis Museum of Art is in your plans. The building and decor is old and eclectic. Room was quiet and the bed comfortable, but felt a bit run down and could have been cleaned better. The bar/restaurant "Basso" is steps away for great food, a lively bar and moderate prices. The provided lobby breakfast/coffee was simple but fine.

Reviewed on Jan 24, 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Price was $807, price is now $623 per person
$623
per person
Mar 9 - Mar 15
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (425 reviews)
Very nice place! But no room cleaning at Sunday?!

Reviewed on Jan 27, 2026

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De Soto Hotel Deals

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
$265 nightly
The price is $275 total per night from Feb 3 to Feb 4
$275 total
Feb 3 - Feb 4
Total with taxes and fees
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (63 reviews)
This place was fantastic! Just pack your clothes and food—everything else is provided. We truly enjoyed our stay at the cabin and can’t wait to return. Thank you for the great hospitality.

Reviewed on Jan 2, 2026

Get rates
Secluded cabin on private property
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $104 total per night from Feb 2 to Feb 3
$104 total
Feb 2 - Feb 3
Total with taxes and fees
9.2/10 Wonderful! (1,001 reviews)
Clean room, amenities, staff, and proximity to very good fining options.

Reviewed on Jan 23, 2026

Pear Tree Inn St. Louis Arnold
See all 180 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best De Soto Vacation Packages

De Soto Essential Information

Language
English
Currency
U.S dollars
Population
6,500
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a De Soto vacation package cost?
Offering excellent value package deals from $506 on Expedia, you'll be surprised at how little a vacation to De Soto costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to De Soto?
If you're looking to score a cheap De Soto vacation package, consider planning a trip in June, October and November. You're likely to find lower prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for De Soto?
Generally, a handful of days is enough to tick off the top sights during your De Soto vacation. However, if you'd like to have time to relax or take day tours, think about extending your trip.
How to find the best De Soto package deals?
Use Expedia's filters to help you find some tempting De Soto package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for De Soto package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a De Soto vacation as a package?
You can enjoy significant savings on your next De Soto retreat by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to De Soto?
If you're considering a spontaneous De Soto adventure, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land terrific deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later De Soto vacation packages?
Set off on your dream trip to De Soto with help from our Book Now, Pay Later vacations. No need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snap up cheap deals before they sell out.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.