De Soto Vacations from $223

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Your De Soto Vacation

Experience the unique character and personality of De Soto with a tailor-made De Soto vacation package. From its welcoming locals to its rich history, you'll never have a boring moment in this city. A trip to De Soto wouldn't be complete without visiting a few top attractions, starting with Victoria Glaces Conservation Area Trailhead. No matter your travel plans or budget, organizing a tailored De Soto vacation is a cinch with Expedia.

The Latest De Soto vacation packages

Price found within the past 48 hours. Click for updated prices.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was $295, price is now $223 per person
$223
per person
Apr 7 - Apr 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,056 reviews)
Property was clean and the staff was very helpful. We needed a remote for our room and it came very quickly after asking. We needed silverware for food we ordered and the front desk was able to assist with this.

Reviewed on Mar 6, 2026

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $1,005, price is now $557 per person
$557
per person
Apr 22 - Apr 25
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,626 reviews)
2nd time was as good as the first.

Reviewed on Mar 6, 2026

Hotel Saint Louis, Autograph Collection

Hotel Saint Louis, Autograph Collection

4 out of 5
Downtown St. Louis
Price was $374, price is now $274 per person
$274
per person
Apr 7 - Apr 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (476 reviews)
Great Luxury Hotel and location.

Reviewed on Mar 4, 2026

Hotel Indigo St. Louis - Downtown by IHG

Hotel Indigo St. Louis - Downtown by IHG

3.5 out of 5
Downtown St. Louis
Save 100% on your flight
Price was $599, price is now $450 per person
$450
per person
Apr 22 - Apr 25
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.4/10 Good! (349 reviews)
Staff was amazing! Rooms were beautiful! Close to Gateway Arch National Park!

Reviewed on Mar 6, 2026

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was $347, price is now $265 per person
$265
per person
Apr 7 - Apr 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.4/10 Very Good! (1,005 reviews)
The hotel and Casino were very clean and offered many dining and entertainment options without having to leave the property. Our only complaint was a staff member loudly banging on our hotel room door at 930pm insisting that she needed to check the room. It was pretty jarring as my husband was in the shower and I was already dressed for bed watching TV. She identified herself as a housekeeping staff member and I let her enter the room then she just turned around and left. I have no idea what it was about. Everything else about the stay was great though!

Reviewed on Mar 4, 2026

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De Soto Hotel Deals

82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto MO
10/10 Exceptional! (41 reviews)
The cabin was cozy; comfortable; clean; everything we needed; decorated nicely plus Christmas tree and decor; friendly and attentive hosts. There are not enough nice things to say about them. If I could rate it a 20 out of 10 I would. We will stay again if available next time!! There were home laid ...

Reviewed on Dec 8, 2025

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82 Acre Hobby Farm with Lincoln Log Cabin
Secluded cabin on private property

Secluded cabin on private property

De Soto MO
10/10 Exceptional! (64 reviews)
We absolutely loved this little slice of heaven . We will be definitely be coming back later this summer

Reviewed on Feb 23, 2026

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Secluded cabin on private property
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $66 total per night from Mar 15 to Mar 16
$66 total
Mar 15 - Mar 16
Total with taxes and fees
8/10 Very Good! (1,008 reviews)
It's an ok place for the price to stay for one night. I would not count on a breakfast as it is one of the worst in my travel experience. Just skip it.

Reviewed on Mar 6, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
See all 183 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best De Soto Vacation Packages

De Soto Essential Information

Language
English
Currency
U.S dollars
Population
6,500
Max Temp Winter
45ºF
Max Temp Summer
90ºF

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Frequently asked questions

How much does a De Soto vacation package cost?
Offering excellent value package deals from $223 on Expedia, you'll be surprised at how little a vacation to De Soto costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to De Soto?
If you're looking to score a cheap De Soto vacation package, consider planning a trip in June, October and November. You're likely to find lower prices on airfares and hotels during these months — perfect for a budget-friendly break.
How many days is enough for De Soto?
Generally, a handful of days is enough to tick off the top sights during your De Soto vacation. However, if you'd like to have time to relax or take day tours, think about extending your trip.
How to find the best De Soto package deals?
Use Expedia's filters to help you find some tempting De Soto package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or search for De Soto package deals in the off-peak season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package well in advance.
Is it cheaper to book a De Soto vacation as a package?
You can enjoy significant savings on your next De Soto retreat by booking a personalized vacation package. Check the "Package" heading, then select your travel dates and destination to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may score a better deal.
When to book a vacation package to De Soto?
If you're considering a spontaneous De Soto adventure, browse our last-minute deals that can be booked up to a week before you take off. Prefer not to wait until the last minute? You can land terrific deals on your hotels and flights by booking well in advance.
Does Expedia offer Book Now, Pay Later De Soto vacation packages?
Set off on your dream trip to De Soto with help from our Book Now, Pay Later vacations. No need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans mean you can spread the cost over 3, 6 or 12 months. With no late payment fees or extra charges, you can easily stay on budget and snap up cheap deals before they sell out.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.